Transgenic mouse model for the study of enterovirus 71 neuropathogenesis - Fujii, Ken; Nagata, Noriyo; Sato, Yuko; Ong, Kien Chai; Wong, Kum Thong; Yamayoshi, Seiya; Shimanuki, Midori; Shitara, Hiroshi; Taya, Choji; Koike, Satoshi (Proceedings of the National Academy of Sciences - PNAS, 2013)
Keywords: Animal models; Animals; ataxia (disorder); Biological Sciences; Blotting, Western; Brain - metabolism; Brain - pathology; Brain - virology; brain stem; Cell Line, Tumor; Central Nervous System Diseases - genetics; Central Nervous System Diseases - metabolism; Central Nervous System Diseases - virology; cerebellum; cerebrum; children; Chlorocebus aethiops; death; Disease models; Disease Models, Animal; encephalitis; Enterovirus; Enterovirus A; Enterovirus A, Human - physiology; Enterovirus Infections - genetics; Enterovirus Infections - metabolism; Enterovirus Infections - virology; Epidemics; ethics; Hand foot and mouth disease; Host-Pathogen Interactions; Humans; hypothalamus; Immunohistochemistry; Infections; Lysosomal Membrane Proteins - genetics; Lysosomal Membrane Proteins - metabolism; Medical ethics; Mice; Mice, Transgenic; monkeys; mortality; neonates; Nervous system diseases; Neurology; Neurons; paralysis; Pathogenesis; Pathology; Public health; Receptors; Receptors, Scavenger - genetics; Receptors, Scavenger - metabolism; Rodents; spinal cord; Spinal Cord - metabolism; Spinal Cord - pathology; Spinal Cord - virology; thalamus; Time Factors; transgenic animals; vaccines; Vero Cells; Virology; virus receptors; Viruses; Asia-Pacific region; neurotropism; viral receptor; picornavirus