Bone response to fast-degrading, injectable calcium phosphate cements containing PLGA microparticles

• Published in: Biomaterials Vol. 32; no. 34; pp. 8839 - 8847
• Main Authors: Félix Lanao, Rosa P., Leeuwenburgh, Sander C.G., Wolke, Joop G.C., Jansen, John A.
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Ltd 01.12.2011
• Subjects: Advanced Basic Science; Animals; biocompatibility; Biocompatible Materials - administration & dosage; Biocompatible Materials - metabolism; biodegradability; Bone; Bone Cements - metabolism; Bone Regeneration; Calcium phosphate cement; calcium phosphates; Calcium Phosphates - administration & dosage; Calcium Phosphates - metabolism; Dentistry; Female; Femur - physiology; Injections; In vivo; Lactic Acid - administration & dosage; Lactic Acid - metabolism; Microspheres; PLGA; Polyglycolic Acid - administration & dosage; Polyglycolic Acid - metabolism; Porosity; Rabbits; Microspheres; Calcium phosphate cement; PLGA; Bone; In vivo

Apatitic calcium phosphate cements (CPC) are frequently used to fill bone defects due to their favourable clinical handling and excellent bone response, but their lack of degradability inhibits complete bone regeneration. In order to render these injectable CaP cements biodegradable, hollow microsph...