Effects of Type 2 Diabetes on Insulin Secretion, Insulin Action, Glucose Effectiveness, and Postprandial Glucose Metabolism

• Published in: Diabetes care Vol. 32; no. 5; pp. 866 - 872
• Main Authors: Basu, Ananda, Dalla Man, Chiara, Basu, Rita, Toffolo, Gianna, Cobelli, Claudio, Rizza, Robert A
• Format: Journal Article
• Language: English
• Published: Alexandria, VA American Diabetes Association 01.05.2009
• Subjects: administration & dosage; Analysis; Biological and medical sciences; blood; Blood Glucose; Blood Glucose - metabolism; body mass index; c-peptide; C-Peptide - blood; Dextrose; Diabetes; Diabetes Mellitus, Type 2; Diabetes Mellitus, Type 2 - blood; Diabetes Mellitus, Type 2 - physiopathology; Diabetes. Impaired glucose tolerance; Endocrine pancreas. Apud cells (diseases); Endocrinopathies; Etiopathogenesis. Screening. Investigations. Target tissue resistance; Fasting; Glucose; Glucose - administration & dosage; Glucose - pharmacology; Glucose metabolism; Health services; Humans; Hyperglycemia; Infusions, Intravenous; ingestion; Insulin; Insulin - blood; Insulin - metabolism; Insulin Secretion; Kinetics; Mass spectrometry; Medical sciences; Metabolic diseases; Metabolism; Miscellaneous; noninsulin-dependent diabetes mellitus; Original Research; pharmacology; Physiological aspects; physiopathology; Plasma; Postprandial Period; Public health. Hygiene; Public health. Hygiene-occupational medicine; Ratios; Reference Values; Science activities; secretion; Studies; Type 2 diabetes; Endocrinopathy; Type 2 diabetes; Human; Pancreatic hormone; Nutrition; Postprandial; Secretion; Metabolic diseases; Glucose; Metabolism; Insulin; Efficiency; Endocrinology

OBJECTIVE: In this study, we sought to determine whether postprandial insulin secretion, insulin action, glucose effectiveness, and glucose turnover were abnormal in type 2 diabetes. RESEARCH DESIGN AND METHODS: Fourteen subjects with type 2 diabetes and 11 nondiabetic subjects matched for age, weig...