Pyruvate and Metabolic Flexibility: Illuminating a Path Toward Selective Cancer Therapies

• Published in: Trends in biochemical sciences (Amsterdam. Regular ed.) Vol. 41; no. 3; pp. 219 - 230
• Main Authors: Olson, Kristofor A., Schell, John C., Rutter, Jared
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.03.2016
• Subjects: cancer; Glycolysis; Humans; metabolic flexibility; metabolic heterogeneity; metabolism; mitochondria; neoplasm cells; neoplasms; Neoplasms - metabolism; Neoplasms - therapy; oxidation; Oxidation-Reduction; phenotype; pyruvate; pyruvic acid; Pyruvic Acid - metabolism; stem cells; therapeutics; stem cells; metabolic flexibility; cancer; metabolism; metabolic heterogeneity; pyruvate

Dysregulated metabolism is an emerging hallmark of cancer, and there is abundant interest in developing therapies to selectively target these aberrant metabolic phenotypes. Sitting at the decision-point between mitochondrial carbohydrate oxidation and aerobic glycolysis (i.e., the ‘Warburg effect’),...