Prognostic significance of 2-hydroxyglutarate levels in acute myeloid leukemia in China

• Published in: Proceedings of the National Academy of Sciences - PNAS Vol. 110; no. 42; pp. 17017 - 17022
• Main Authors: Wang, Jiang-Han, Chen, Wen-Lian, Li, Jun-Min, Wu, Song-Fang, Chen, Tian-Lu, Zhu, Yong-Mei, Zhang, Wei-Na, Li, Yang, Qiu, Yun-Ping, Zhao, Ai-Hua, Mi, Jian-Qing, Jin, Jie, Wang, Yun-Gui, Ma, Qiu-Ling, Huang, He, Wu, De-Pei, Wang, Qin-Rong, Li, Yan, Yan, Xiao-Jing, Yan, Jin-Song, Li, Jian-Yong, Wang, Shuai, Huang, Xiao-Jun, Wang, Bing-Shun, Jia, Wei, Shen, Yang, Chen, Zhu, Chen, Sai-Juan
• Format: Journal Article
• Language: English
• Published: United States National Academy of Sciences 15.10.2013; NATIONAL ACADEMY OF SCIENCES; National Acad Sciences
• Subjects: Biological Sciences; Blasts; blood serum; China; China - epidemiology; Cytogenetics; Disease-Free Survival; DNA; DNA methylation; DNA Methylation - genetics; Enzymes; Female; Gene Expression Regulation, Leukemic - genetics; genes; Genetic mutation; Glutarates - blood; Hematology; Humans; isocitrate dehydrogenase; Isocitrate Dehydrogenase - genetics; Isocitrate Dehydrogenase - metabolism; Leukemia; Leukemia, Myeloid, Acute - blood; Leukemia, Myeloid, Acute - genetics; Leukemia, Myeloid, Acute - mortality; Leukemia, Myeloid, Acute - therapy; Lymphoma; Male; Mass spectrometry; Medical prognosis; Metabolites; Methylation; Middle Aged; multivariate analysis; Mutation; Myeloid leukemia; P values; patients; Statistical median; Survival Rate; China; biomarker; prognosis

The 2-hydroxyglutarate (2-HG) has been reported to result from mutations of isocitrate dehydrogenase 1 and 2 (IDH1 and IDH2) genes and to function as an “oncometabolite.” To evaluate the clinical significance of serum 2-HG levels in hematologic malignancies, acute myeloid leukemia (AML) in particula...