Animal models of congenital zika syndrome provide mechanistic insight into viral pathogenesis during pregnancy

• Published in: PLoS neglected tropical diseases Vol. 14; no. 10; p. e0008707
• Main Authors: Narasimhan, Harish, Chudnovets, Anna, Burd, Irina, Pekosz, Andrew, Klein, Sabra L.
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 01.10.2020; Public Library of Science (PLoS)
• Subjects: Animal models; Animals; Apoptosis; Biology and life sciences; Birth defects; Brain research; Children; Complications and side effects; Congenital defects; Congenital diseases; Cytomegalovirus; Defects; Development and progression; Disabilities; Disease Models, Animal; Downstream effects; Epidemics; Female; Fetuses; Foetus; Genetic factors; Genomes; Guinea pigs; Hamsters; Hepatitis; Hepatitis C; Hepatitis C virus; Immunoglobulins; Immunology; Infections; Influenza; Intrauterine exposure; Laboratories; Medicine and Health Sciences; Offspring; Pathogenesis; Pathogens; Pediatric research; Perinatal infection; Placenta; Pregnancy; Primates; Progeny; Public health; Research and Analysis Methods; Review; Risk factors; Severe acute respiratory syndrome coronavirus 2; Sheep; Tropical diseases; Vector-borne diseases; Viruses; Womens health; Zika virus; Zika Virus - physiology; Zika Virus Infection - congenital; Zika Virus Infection - virology; United States; Uganda; French Polynesia

In utero Zika virus (ZIKV; family Flaviviridae) infection causes a distinct pattern of birth defects and disabilities in the developing fetus and neonate that has been termed congenital zika syndrome (CZS). Over 8,000 children were affected by the 2016 to 2017 ZIKV outbreak in the Americas, many of...