Limiting Cholesterol Biosynthetic Flux Spontaneously Engages Type I IFN Signaling - York, Autumn G.; Williams, Kevin J.; Argus, Joseph P.; Zhou, Quan D.; Brar, Gurpreet; Vergnes, Laurent; Gray, Elizabeth E.; Zhen, Anjie; Wu, Nicholas C.; Yamada, Douglas H.; Cunningham, Cameron R.; Tarling, Elizabeth J.; et al. (Cell, 2015)
Keywords: Animals; biochemical pathways; biosynthesis; Cell Line, Tumor; cholesterol; Cholesterol - metabolism; Humans; Immunity, Innate; innate immunity; Interferon beta-1b; Interferon-gamma - metabolism; interferons; isotopes; long chain fatty acids; macrophages; Membrane Proteins - metabolism; Mevalonic Acid - metabolism; Mice; Mice, Inbred C57BL; Signal Transduction; Sterol Regulatory Element Binding Protein 1 - metabolism; Sterol Regulatory Element Binding Protein 2 - metabolism