An expression atlas of human primary cells: inference of gene function from coexpression networks

• Published in: BMC genomics Vol. 14; no. 1; p. 632
• Main Authors: Mabbott, Neil A, Baillie, J, Brown, Helen, Freeman, Tom C, Hume, David A
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 20.09.2013; BioMed Central
• Subjects: Anopheles; Arrays; B cells; Cluster Analysis; Computational Biology; Data processing; Dendritic cells; Dendritic Cells - metabolism; DNA binding proteins; Gene expression; Gene Regulatory Networks; Genetic aspects; Genetic regulation; Genomes; Genomics; Humans; Macrophages - metabolism; Meta-analysis; Oligonucleotide Array Sequence Analysis; Ontology; Phagocytes; Physiological aspects; Quality control; Stem cells; Transcription factors; Transcription Factors - genetics; Transcriptome
• ISSN: 1471-2164; 1471-2164
• DOI: 10.1186/1471-2164-14-632

The specialisation of mammalian cells in time and space requires genes associated with specific pathways and functions to be co-ordinately expressed. Here we have combined a large number of publically available microarray datasets derived from human primary cells and analysed large correlation graph...