Influenza Virus Non-Structural Protein 1 (NS1) Disrupts Interferon Signaling - Jia, Danlin; Rahbar, Ramtin; Chan, Renee W. Y.; Lee, Suki M. Y.; Chan, Michael C. W.; Wang, Ben Xuhao; Baker, Darren P.; Sun, Bing; Peiris, J. S. Malik; Nicholls, John M.; Fish, Eleanor N. (PloS one, 2010)
Keywords: Antiviral state; Avian influenza; Avian influenza viruses; Biological response modifiers; Cells, Cultured; Deoxyribonucleic acid; Development and progression; DNA; Drug resistance; Gene expression; Gene Expression - drug effects; Genes; Genomes; Green Fluorescent Proteins - genetics; Green Fluorescent Proteins - metabolism; Health aspects; HeLa Cells; Host-Pathogen Interactions; Humans; Immune system; Immunoblotting; Infection; Infections; Infectious Diseases/Viral Infections; Influenza; Influenza A; Influenza A virus - genetics; Influenza A virus - metabolism; Influenza A virus - physiology; Influenza A Virus, H1N1 Subtype - metabolism; Influenza A Virus, H1N1 Subtype - physiology; Influenza A Virus, H5N1 Subtype - metabolism; Influenza A Virus, H5N1 Subtype - physiology; Influenza virus; Inhibition; Interferon; Interferons - metabolism; Interferons - pharmacology; Kinases; Lung - drug effects; Lung - metabolism; Lung - virology; Lungs; Macrophages; Macrophages - cytology; Macrophages - metabolism; Macrophages - virology; Microscopy, Confocal; Monocytes; Nuclear transport; Phosphorylation; Receptor, Interferon alpha-beta - genetics; Receptor, Interferon alpha-beta - metabolism; Replication; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction - physiology; Signaling; Stat1 protein; STAT1 Transcription Factor - metabolism; Stat2 protein; STAT2 Transcription Factor - metabolism; Stat3 protein; Suppressor of Cytokine Signaling 1 Protein; Suppressor of Cytokine Signaling Proteins - genetics; Suppressor of Cytokine Signaling Proteins - metabolism; Swine flu; Tissue Culture Techniques; Tissues; Translocation; Tyrosine; Viral Nonstructural Proteins - genetics; Viral Nonstructural Proteins - metabolism; Viral Nonstructural Proteins - physiology; Virology; Virology/Immune Evasion; Viruses; Hong Kong China; Canada; China