Axenic interspecies and intraclonal hybrid formation in Leishmania: Successful crossings between visceral and cutaneous strains

• Published in: PLoS neglected tropical diseases Vol. 16; no. 2; p. e0010170
• Main Authors: Gutiérrez-Corbo, Camino, Domínguez-Asenjo, Bárbara, Pérez-Pertejo, Yolanda, García-Estrada, Carlos, Bello, Felio J, Balaña-Fouce, Rafael, Reguera, Rosa M.
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 01.02.2022; Public Library of Science (PLoS)
• Subjects: Analysis; Animals; Antibiotic resistance; Antibiotics; Biology and Life Sciences; Cell Line; Cells; Chromosomes; Cutaneous leishmaniasis; Deoxyribonucleic acid; Disease resistance; DNA; Drug resistance; Experiments; Feasibility studies; Fluorescence; Genes; Genetic aspects; Germfree; Growth; Heredity; Hybridization, Genetic; Hybrids; Immune system; Immunity; Laboratories; Leishmania; Leishmania donovani - genetics; Leishmania major - genetics; Leishmania tropica - genetics; Leishmaniasis, Cutaneous - parasitology; Leishmaniasis, Visceral - parasitology; Medicine and Health Sciences; Mitochondrial DNA; Parasites; Parasitic diseases; Phenotypes; Ploidy; Promastigotes; Psychodidae; Public health; Reproduction; Reproduction (biology); Reproductive behaviour; Research and Analysis Methods; Sexual reproduction; Species; Strains; Tropical diseases; Tropism; Tropisms; Varieties; Vector-borne diseases; Virulence; Visceral leishmaniasis; Colombia

Diseases caused by trypanosomatids are serious public health concerns in low-income endemic countries. Leishmaniasis is presented in two main clinical forms, visceral leishmaniasis—caused by L . infantum and L . donovani —and cutaneous leishmaniasis—caused by many species, including L . major , L ....