Determination of Oral Dosage and Pharmacokinetic Analysis of Flecainide in Horses

• Published in: Journal of Veterinary Medical Science Vol. 63; no. 5; pp. 511 - 514
• Main Authors: OHMURA, Hajime, HIRAGA, Atsushi, AIDA, Hiroko, TAKAHASHI, Toshiyuki, NUKADA, Toshio
• Format: Journal Article
• Language: English
• Published: Japan JAPANESE SOCIETY OF VETERINARY SCIENCE 01.05.2001; Japan Science and Technology Agency
• Subjects: Administration, Oral; Animals; Anti-Arrhythmia Agents - administration & dosage; Anti-Arrhythmia Agents - blood; Anti-Arrhythmia Agents - pharmacokinetics; Area Under Curve; Electrocardiography - veterinary; equine; Female; flecainide; Flecainide - administration & dosage; Flecainide - blood; Flecainide - pharmacokinetics; Half-Life; Heart Rate - drug effects; Horses - metabolism; Male; oral administration; pharmacokinetics; Random Allocation

To determine oral dosage and to evaluate the pharmacokinetics in horses of orally administered flecainide, an antiarrhythmic drug, the correlations between its plasma concentration and PR, QRS and QT intervals in equine electrocardiograms (ECG) were investigated. Six healthy horses were administered...