Impacts of antioxidants on hydroxyl radical production from individual and mixed transition metals in a surrogate lung fluid

• Published in: Atmospheric environment (1994) Vol. 45; no. 40; pp. 7555 - 7562
• Main Authors: Charrier, Jessica G., Anastasio, Cort
• Format: Journal Article Conference Proceeding
• Language: English
• Published: Kidlington Elsevier Ltd 01.12.2011; Elsevier
• Subjects: antioxidants; Applied sciences; atmospheric chemistry; Atmospheric pollution; Biological and medical sciences; breathing; cadmium; Chemical and industrial products toxicology. Toxic occupational diseases; chromium; citrates; cobalt; Copper; Exact sciences and technology; Fenton reaction; glutathione; humans; hydroxyl radicals; inflammation; Iron; lead; lungs; manganese; Medical sciences; Metals and various inorganic compounds; morbidity; mortality; nickel; Oxidative stress; Particulate matter (PM); particulates; Pollution; quantitative analysis; Reactive oxygen species (ROS); toxicity; Toxicology; uric acid; vanadium; zinc; Oxidative stress; Fenton reaction; Iron; Particulate matter (PM); Copper; Reactive oxygen species (ROS); Human; Respiratory disease; Toxicity; Lung; Transition metal; Antioxidant; Mixture; Heavy metal; Trace element; Suspended particle; Aerosols; Oxidation; Mechanism of action

Inhalation of ambient particulate matter causes morbidity and mortality in humans. One hypothesized mechanism of toxicity is the particle-induced formation of reactive oxygen species (ROS) – including the highly damaging hydroxyl radical ( OH) – followed by inflammation and a variety of diseases. Wh...