Mechanical regulation of stem-cell differentiation by the stretch-activated Piezo channel

• Published in: Nature (London) Vol. 555; no. 7694; pp. 103 - 106
• Main Authors: He, Li, Si, Guangwei, Huang, Jiuhong, Samuel, Aravinthan D. T., Perrimon, Norbert
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.03.2018; Nature Publishing Group
• Subjects: 14/19; 631/136/142; 631/136/532/2437; 631/532/2118/2437; 631/532/2437; 64/24; Animals; Calcium - metabolism; Calcium ions; Calcium Signaling; Calcium signalling; Cell Differentiation; Cell growth; Cell Lineage; Cell Proliferation; Cell self-renewal; Compression; Cytological research; Cytosol - metabolism; Differentiation (biology); Digestive System - cytology; Digestive System - metabolism; Drosophila; Drosophila melanogaster - cytology; Drosophila melanogaster - metabolism; Drosophila Proteins - genetics; Drosophila Proteins - metabolism; Ectopic expression; Enteroendocrine Cells - cytology; Enteroendocrine Cells - metabolism; Female; Genomes; Homeostasis; Humanities and Social Sciences; Insects; Ion channels; Ion Channels - genetics; Ion Channels - metabolism; letter; Mechanical stimuli; Midgut; multidisciplinary; Mutation; Oxidative stress; Phenotypes; Proteins; Science; Signal transduction; Stem cells; Stem Cells - cytology; Stress, Mechanical

Stem cells of the Drosophila midgut sense mechanical signals in vivo through the stretch-activated ion channel Piezo, which is expressed on previously unidentified enteroendocrine precursor cells. Stretch-activated ion channel drives cell differentiation The effect of mechanical cues on the behaviou...