Herpes-virus infection in patients with Langerhans cell histiocytosis: a case-controlled sero-epidemiological study, and in situ analysis

• Published in: PloS one Vol. 3; no. 9; p. e3262
• Main Authors: Jeziorski, Eric, Senechal, Brigitte, Molina, Thierry Jo, Devez, Francis, Leruez-Ville, Marianne, Morand, Patrice, Glorion, Christophe, Mansuy, Ludovic, Gaudelus, Joel, Debre, Marianne, Jaubert, Francis, Seigneurin, Jean-Marie, Thomas, Caroline, Joab, Irene, Donadieu, Jean, Geissmann, Frederic
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 23.09.2008; Public Library of Science (PLoS)
• Subjects: Adolescent; Adult; Age; Analysis; Antibodies; Antibody response; Antigens, CD1 - biosynthesis; Antigens, CD20 - biosynthesis; Autoimmune diseases; B cells; Biology; Blood & organ donations; Bone marrow; Case-Control Studies; CD20 antigen; CD79 Antigens - biosynthesis; Child; Child, Preschool; Children; Cohort Studies; Copy number; Cytomegalovirus; Cytomegalovirus - metabolism; Dendritic cells; Deoxyribonucleic acid; Disease; DNA; Epidemiology; Epstein-Barr virus; Genomes; Granuloma; Hematology/Pediatric Hematology; Herpes viruses; Herpesviridae Infections - complications; Herpesviridae Infections - diagnosis; Herpesviridae Infections - epidemiology; Herpesvirus 4, Human - metabolism; Herpesvirus 6, Human - metabolism; Histiocytosis; Histiocytosis, Langerhans-Cell - complications; Histiocytosis, Langerhans-Cell - diagnosis; Histiocytosis, Langerhans-Cell - epidemiology; Histiocytosis, Langerhans-Cell - virology; Humans; Immunosuppression; Immunosuppressive Agents - pharmacology; Infant; Infection; Infections; Laboratories; Langerhans cell histiocytosis; Langerhans cells; Localization; Lymphocytes; Lymphocytes B; Lymphoma; Medical research; Pathogenesis; Patients; Pediatrics and Child Health; Pediatrics and Child Health/Pediatric Oncology; Polymerase chain reaction; Rare diseases; Studies; Virology; Virology/Viruses and Cancer; Virus diseases; Viruses; France

Langerhans cell histiocytosis (LCH) is a rare disease that affects mainly young children, and which features granulomas containing Langerhans-type dendritic cells. The role of several human herpesviruses (HHV) in the pathogenesis of LCH was suggested by numerous reports but remains debated. Epstein-...