Contribution of Lewis X Carbohydrate Structure to Neuropathogenic Murine Coronaviral Spread

• Published in: Japanese Journal of Infectious Diseases Vol. 69; no. 5; pp. 405 - 413
• Main Authors: Kakizaki, Masatoshi, Togayachi, Akira, Narimatsu, Hisashi, Watanabe, Rihito
• Format: Journal Article
• Language: English
• Published: Japan National Institute of Infectious Diseases, Japanese Journal of Infectious Diseases Editorial Committee 2016
• Subjects: Animals; bystander effect; Cells, Cultured; Coronaviridae; Coronavirus - growth & development; Coronavirus - physiology; Fut9; JHM; Lewis X Antigen - metabolism; Macrophages - chemistry; Macrophages - immunology; Macrophages - virology; Mice, Inbred BALB C; Monocytes - chemistry; Monocytes - immunology; Monocytes - virology; thioglycollate; Virus Internalization

Although Lewis X (Lex), a carbohydrate structure, is involved in innate immunity through cell-to-cell and pathogen recognition, its expression has not been observed in mouse monocytes/macrophages (Mo/Mas). The Mo/Mas that infiltrate the meninges after infection with the neuropathogenic murine corona...