RIG-I, MDA5 and TLR3 synergistically play an important role in restriction of dengue virus infection

• Published in: PLoS neglected tropical diseases Vol. 5; no. 1; p. e926
• Main Authors: Nasirudeen, A M A, Wong, Hui Hui, Thien, Peiling, Xu, Shengli, Lam, Kong-Peng, Liu, Ding Xiang
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 04.01.2011; Public Library of Science (PLoS)
• Subjects: Animals; Apoptosis; Cells, Cultured; Cytokines; DEAD Box Protein 58; DEAD-box RNA Helicases - immunology; DEAD-box RNA Helicases - metabolism; Dengue - immunology; Dengue - pathology; Dengue fever; Dengue virus; Dengue Virus - immunology; Dengue Virus - pathogenicity; Dengue virus type 1; Gene Silencing; Genes; Genetic engineering; Hepatitis; Hepatocytes - virology; Humans; Immune response; Immune system; Immunology/Cellular Microbiology and Pathogenesis; Immunology/Immune Response; Immunology/Immunity to Infections; Immunology/Innate Immunity; Infections; Interferon; Interferon-Induced Helicase, IFIH1; Interferons - immunology; Interferons - metabolism; Macrophages - virology; Melanoma; Mice; Mice, Inbred C57BL; Microbiology/Cellular Microbiology and Pathogenesis; Microbiology/Innate Immunity; Pattern recognition; Receptors, Immunologic; Reverse Transcriptase Polymerase Chain Reaction; Sensors; Toll-Like Receptor 3 - immunology; Toll-Like Receptor 3 - metabolism; Tropical diseases; Vector-borne diseases; Viral diseases; Viral infections; Viruses; West Nile virus; Singapore; Asia; Toll-Like Receptor 3; DEAD-box RNA Helicases; Interferons; Dengue; Humans; Mice, Inbred C57BL; Cells, Cultured; Gene Silencing; Macrophages; Reverse Transcriptase Polymerase Chain Reaction; Dengue Virus; Animals; Hepatocytes; Mice; Apoptosis

Dengue virus (DV) infection is one of the most common mosquito-borne viral diseases in the world. The innate immune system is important for the early detection of virus and for mounting a cascade of defense measures which include the production of type 1 interferon (IFN). Hence, a thorough understan...