Cutting-edge advances in modeling the blood–brain barrier and tools for its reversible permeabilization for enhanced drug delivery into the brain

• Published in: Cell & bioscience Vol. 13; no. 1; pp. 137 - 21
• Main Authors: Sharma, A., Fernandes, D. C., Reis, R. L., Gołubczyk, D., Neumann, S., Lukomska, B., Miroslaw, J., Kortylewski, M., Walczak, P., Oliveira, Joaquim M., Maciaczyk, J.
• Format: Journal Article
• Language: English
• Published: England BMC 27.07.2023; BioMed Central Ltd; BioMed Central
• Subjects: BBB; Blood-brain barrier; Brain; Brain cancer; Brain research; Central nervous system; Drug delivery; Drug delivery systems; Drug targets; Drugs; Focused ultrasound; Gender differences; In vitro models; In vivo models; Kinases; Metastases; Mutation; Nervous system diseases; Neurological diseases; Organoid models; Permeability; Proteins; Review; Vehicles; In vitro models; Drug targets; Intra-arterial infusion; Organoid models; In vivo models; Drug delivery; Focused ultrasound; Blood–brain barrier

The bloodâ brain barrier (BBB) is a sophisticated structure whose full functionality is required for maintaining the executive functions of the central nervous system (CNS). Tight control of transport across the barrier means that most drugs, particularly large size, which includes powerful biologic...