Cutting-edge advances in modeling the blood–brain barrier and tools for its reversible permeabilization for enhanced drug delivery into the brain

The bloodâ brain barrier (BBB) is a sophisticated structure whose full functionality is required for maintaining the executive functions of the central nervous system (CNS). Tight control of transport across the barrier means that most drugs, particularly large size, which includes powerful biologic...

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Published inCell & bioscience Vol. 13; no. 1; pp. 137 - 21
Main Authors Sharma, A., Fernandes, D. C., Reis, R. L., Gołubczyk, D., Neumann, S., Lukomska, B., Miroslaw, J., Kortylewski, M., Walczak, P., Oliveira, Joaquim M., Maciaczyk, J.
Format Journal Article
LanguageEnglish
Published England BMC 27.07.2023
BioMed Central Ltd
BioMed Central
Subjects
BBB
Blood-brain barrier
Brain
Brain cancer
Brain research
Central nervous system
Drug delivery
Drug delivery systems
Drug targets
Drugs
Focused ultrasound
Gender differences
In vitro models
In vivo models
Kinases
Metastases
Mutation
Nervous system diseases
Neurological diseases
Organoid models
Permeability
Proteins
Review
Vehicles
In vitro models
Drug targets
Intra-arterial infusion
Organoid models
In vivo models
Drug delivery
Focused ultrasound
Blood–brain barrier
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Abstract The bloodâ brain barrier (BBB) is a sophisticated structure whose full functionality is required for maintaining the executive functions of the central nervous system (CNS). Tight control of transport across the barrier means that most drugs, particularly large size, which includes powerful biologicals, cannot reach their targets in the brain. Notwithstanding the remarkable advances in characterizing the cellular nature of the BBB and consequences of BBB dysfunction in pathology (brain metastasis, neurological diseases), it remains challenging to deliver drugs to the CNS. Herein, we outline the basic architecture and key molecular constituents of the BBB. In addition, we review the current status of approaches that are being explored to temporarily open the BBB in order to allow accumulation of therapeutics in the CNS. Undoubtedly, the major concern in field is whether it is possible to open the BBB in a meaningful way without causing negative consequences. In this context, we have also listed few other important key considerations that can improve our understanding about the dynamics of the BBB. The authors, DCF, RLR and JMO, would like to thank the funds under the project 2IQBIONEURO (reference: 0624_2IQBIONEURO_6_E) co-funded by INTERREG (Atlantic (Atlantic program or 622 V-A Spain-Portugal) and European fund for Regional Development (FEDER). Open Access funding enabled and organized by Projekt DEAL.
AbstractList The blood-brain barrier (BBB) is a sophisticated structure whose full functionality is required for maintaining the executive functions of the central nervous system (CNS). Tight control of transport across the barrier means that most drugs, particularly large size, which includes powerful biologicals, cannot reach their targets in the brain. Notwithstanding the remarkable advances in characterizing the cellular nature of the BBB and consequences of BBB dysfunction in pathology (brain metastasis, neurological diseases), it remains challenging to deliver drugs to the CNS. Herein, we outline the basic architecture and key molecular constituents of the BBB. In addition, we review the current status of approaches that are being explored to temporarily open the BBB in order to allow accumulation of therapeutics in the CNS. Undoubtedly, the major concern in field is whether it is possible to open the BBB in a meaningful way without causing negative consequences. In this context, we have also listed few other important key considerations that can improve our understanding about the dynamics of the BBB.
The blood-brain barrier (BBB) is a sophisticated structure whose full functionality is required for maintaining the executive functions of the central nervous system (CNS). Tight control of transport across the barrier means that most drugs, particularly large size, which includes powerful biologicals, cannot reach their targets in the brain. Notwithstanding the remarkable advances in characterizing the cellular nature of the BBB and consequences of BBB dysfunction in pathology (brain metastasis, neurological diseases), it remains challenging to deliver drugs to the CNS. Herein, we outline the basic architecture and key molecular constituents of the BBB. In addition, we review the current status of approaches that are being explored to temporarily open the BBB in order to allow accumulation of therapeutics in the CNS. Undoubtedly, the major concern in field is whether it is possible to open the BBB in a meaningful way without causing negative consequences. In this context, we have also listed few other important key considerations that can improve our understanding about the dynamics of the BBB. Keywords: Blood-brain barrier, Drug targets, In vitro models, In vivo models, Drug delivery, Organoid models, Focused ultrasound, Intra-arterial infusion
The bloodâ brain barrier (BBB) is a sophisticated structure whose full functionality is required for maintaining the executive functions of the central nervous system (CNS). Tight control of transport across the barrier means that most drugs, particularly large size, which includes powerful biologicals, cannot reach their targets in the brain. Notwithstanding the remarkable advances in characterizing the cellular nature of the BBB and consequences of BBB dysfunction in pathology (brain metastasis, neurological diseases), it remains challenging to deliver drugs to the CNS. Herein, we outline the basic architecture and key molecular constituents of the BBB. In addition, we review the current status of approaches that are being explored to temporarily open the BBB in order to allow accumulation of therapeutics in the CNS. Undoubtedly, the major concern in field is whether it is possible to open the BBB in a meaningful way without causing negative consequences. In this context, we have also listed few other important key considerations that can improve our understanding about the dynamics of the BBB. The authors, DCF, RLR and JMO, would like to thank the funds under the project 2IQBIONEURO (reference: 0624_2IQBIONEURO_6_E) co-funded by INTERREG (Atlantic (Atlantic program or 622 V-A Spain-Portugal) and European fund for Regional Development (FEDER). Open Access funding enabled and organized by Projekt DEAL.
Abstract The blood–brain barrier (BBB) is a sophisticated structure whose full functionality is required for maintaining the executive functions of the central nervous system (CNS). Tight control of transport across the barrier means that most drugs, particularly large size, which includes powerful biologicals, cannot reach their targets in the brain. Notwithstanding the remarkable advances in characterizing the cellular nature of the BBB and consequences of BBB dysfunction in pathology (brain metastasis, neurological diseases), it remains challenging to deliver drugs to the CNS. Herein, we outline the basic architecture and key molecular constituents of the BBB. In addition, we review the current status of approaches that are being explored to temporarily open the BBB in order to allow accumulation of therapeutics in the CNS. Undoubtedly, the major concern in field is whether it is possible to open the BBB in a meaningful way without causing negative consequences. In this context, we have also listed few other important key considerations that can improve our understanding about the dynamics of the BBB.
The blood-brain barrier (BBB) is a sophisticated structure whose full functionality is required for maintaining the executive functions of the central nervous system (CNS). Tight control of transport across the barrier means that most drugs, particularly large size, which includes powerful biologicals, cannot reach their targets in the brain. Notwithstanding the remarkable advances in characterizing the cellular nature of the BBB and consequences of BBB dysfunction in pathology (brain metastasis, neurological diseases), it remains challenging to deliver drugs to the CNS. Herein, we outline the basic architecture and key molecular constituents of the BBB. In addition, we review the current status of approaches that are being explored to temporarily open the BBB in order to allow accumulation of therapeutics in the CNS. Undoubtedly, the major concern in field is whether it is possible to open the BBB in a meaningful way without causing negative consequences. In this context, we have also listed few other important key considerations that can improve our understanding about the dynamics of the BBB.The blood-brain barrier (BBB) is a sophisticated structure whose full functionality is required for maintaining the executive functions of the central nervous system (CNS). Tight control of transport across the barrier means that most drugs, particularly large size, which includes powerful biologicals, cannot reach their targets in the brain. Notwithstanding the remarkable advances in characterizing the cellular nature of the BBB and consequences of BBB dysfunction in pathology (brain metastasis, neurological diseases), it remains challenging to deliver drugs to the CNS. Herein, we outline the basic architecture and key molecular constituents of the BBB. In addition, we review the current status of approaches that are being explored to temporarily open the BBB in order to allow accumulation of therapeutics in the CNS. Undoubtedly, the major concern in field is whether it is possible to open the BBB in a meaningful way without causing negative consequences. In this context, we have also listed few other important key considerations that can improve our understanding about the dynamics of the BBB.
ArticleNumber 137
Audience Academic
Author Neumann, S.
Kortylewski, M.
Fernandes, D. C.
Walczak, P.
Gołubczyk, D.
Lukomska, B.
Sharma, A.
Reis, R. L.
Miroslaw, J.
Maciaczyk, J.
Oliveira, Joaquim M.
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BackLink https://www.ncbi.nlm.nih.gov/pubmed/37501215$$D View this record in MEDLINE/PubMed
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Cites_doi 10.1016/j.omtn.2021.12.029
10.1038/jcbfm.2008.117
10.1093/neuonc/noaa206
10.3233/JAD-160542
10.1016/j.bbrc.2019.10.079
10.1016/j.wneu.2019.01.103
10.1016/j.jconrel.2021.01.023
10.3389/fbioe.2021.797359
10.1021/acs.molpharmaceut.8b01056
10.3389/fonc.2020.01443
10.1126/science.aau6977
10.1016/j.cell.2016.05.082
10.7150/thno.43169
10.1021/acs.molpharmaceut.9b00519
10.3389/fneur.2021.749047
10.1038/s41598-019-42272-0
10.1002/bit.26967
10.1148/radiol.10090699
10.1016/j.jconrel.2014.09.018
10.1002/ijc.22732
10.1073/pnas.1807105115
10.1016/j.peptides.2014.09.018
10.1227/00006123-198007000-00006
10.1007/s00259-019-04347-y
10.1007/s00395-013-0388-3
10.1093/ons/opz374
10.1002/cne.901520402
10.3171/2019.11.JNS192224
10.1136/bcr-2018-014469
10.3389/fnmol.2020.570045
10.1007/s13346-016-0319-6
10.1016/j.wneu.2019.07.137
10.1016/j.jconrel.2019.07.026
10.2147/IJN.S117210
10.1038/s41467-022-28785-9
10.1016/j.nbd.2020.105131
10.1038/s41467-018-04529-6
10.4155/fmc-2018-0436
10.1016/j.jconrel.2019.11.019
10.1016/j.jconrel.2017.09.001
10.1038/s41598-019-40973-0
10.3389/fphar.2019.00086
10.1126/science.173.4001.1026
10.1371/journal.pone.0097655
10.1371/journal.pone.0262677
10.1016/j.jconrel.2015.02.033
10.3390/pharmaceutics13111885
10.3389/fneng.2013.00007
10.1093/jnci/80.2.84
10.1161/STROKEAHA.110.606368
10.1007/s00401-018-1815-1
10.1016/j.neuroimage.2004.06.046
10.1177/0271678X15615875
10.1155/2021/9886877
10.1002/glia.21026
10.1038/nbt.1807
10.1002/cpt.1983
10.1161/CIR.0000000000000950
10.1021/acs.molpharmaceut.8b01344
10.1021/acs.jmedchem.1c00910
10.1186/2191-219X-2-57
10.3390/ijms21030934
10.1007/s12031-011-9629-9
10.1016/j.jconrel.2021.06.037
10.1016/j.jconrel.2018.05.005
10.1039/D0BM01726D
10.1021/ol302791x
10.1016/j.expneurol.2020.113203
10.1073/pnas.2002571117
10.1177/0271678X17703888
10.1038/s41551-020-0565-2
10.1186/s12987-019-0139-4
10.1007/s11060-021-03851-2
10.1007/s00441-014-1811-2
10.1016/j.jconrel.2018.05.008
10.1073/pnas.2021915118
10.1002/advs.201900962
10.1016/j.nano.2013.12.006
10.1016/j.colsurfb.2018.09.047
10.1016/j.biomaterials.2021.120942
10.2967/jnumed.118.218792
10.1021/acsami.9b10787
10.1038/s41536-018-0046-3
10.1038/s41598-019-52213-6
10.1016/j.tiv.2021.105112
10.1126/science.aaz5626
10.1039/C7IB00024C
10.1002/adhm.201901486
10.1172/JCI41911
10.3389/fnins.2020.00764
10.1073/pnas.0604318103
10.1016/j.jns.2008.05.019
10.3390/biom8030077
10.3390/md17020081
10.1021/acs.bioconjchem.9b00085
10.1038/s41573-021-00139-y
10.1016/j.bbrc.2005.12.112
10.1016/j.ijrobp.2020.12.019
10.1038/s41598-017-01304-3
10.1111/j.1549-8719.2011.00096.x
10.1007/s12035-020-02023-z
10.1152/ajpcell.1999.276.5.C1148
10.1152/ajplegacy.1970.219.1.270
10.1038/jcbfm.2012.126
10.2217/nnm-2017-0022
10.1016/j.ejmech.2021.114090
10.1038/s41571-021-00529-6
10.3390/ijms22137057
10.3389/fmedt.2020.623950
10.7150/thno.35892
10.3389/fnhum.2020.593672
10.3390/cells10082036
10.1002/btm2.10153
10.1016/j.drudis.2020.11.009
10.1038/jcbfm.2012.100
10.1126/science.176.4040.1243
10.1038/s41592-019-0586-5
10.2174/1567201816666190828153017
10.1016/j.stem.2019.08.002
10.1161/STROKEAHA.107.500470
10.1371/journal.pone.0150360
10.1016/j.stem.2018.12.015
10.1177/0271678X19867980
10.3171/2021.3.PEDS20738
10.1371/journal.pone.0028881
10.1016/j.biomaterials.2018.10.023
10.1016/j.jconrel.2017.01.039
10.1021/bc500475e
10.3390/pharmaceutics13060892
10.1089/hum.2012.013
10.7150/ijbs.45885
10.3389/fnins.2021.747726
10.1016/j.jpha.2020.08.006
10.3390/cancers13225614
10.1172/JCI24751
10.1016/j.ijpharm.2018.07.033
10.1371/journal.pone.0086407
10.1371/journal.pone.0010549
10.1038/s41598-018-36340-0
10.1089/biores.2019.0026
10.1371/journal.pone.0192240
10.1371/journal.pone.0027877
10.1016/j.yfrne.2022.100989
10.1148/radiol.12112212
10.1038/jcbfm.2014.74
10.1038/s41467-021-25157-7
10.1146/annurev-neuro-070918-050501
10.1515/revneuro-2013-0039
10.3171/jns.1952.9.4.0378
10.1002/sctm.18-0003
10.1038/s41467-019-10588-0
10.1002/jcb.240470306
10.1177/0271678X18805238
10.1126/science.aat6720
10.1007/s11060-010-0466-4
10.1007/s10439-018-02141-9
10.3389/fnins.2020.00675
10.1186/s12987-021-00276-x
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Issue 1
Keywords In vitro models
Drug targets
Intra-arterial infusion
Organoid models
In vivo models
Drug delivery
Focused ultrasound
Blood–brain barrier
Language English
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References JM Oliveira (1079_CR32) 2018; 3
M Ohshima (1079_CR58) 2019; 8
PS Fishman (1079_CR97) 2021; 12
RM Linville (1079_CR53) 2020; 40
L Alvarez-Erviti (1079_CR144) 2011; 29
EH Wilson (1079_CR155) 2010; 120
N Brandenberg (1079_CR34) 2020; 4
SS Virani (1079_CR43) 2021; 143
A Andrzejewska (1079_CR158) 2019; 39
J Tao (1079_CR153) 2019; 16
M Luo (1079_CR39) 2019; 11
M Zheng (1079_CR145) 2019; 30
DC Fernandes (1079_CR20) 2021; 26
YL Zhao (1079_CR13) 2014; 25
A Michalicova (1079_CR4) 2020; 13
AR Rezai (1079_CR118) 2020; 117
AR Khan (1079_CR31) 2017; 268
WA Banks (1079_CR149) 2001; 297
HL Liu (1079_CR113) 2010; 255
A Jablonska (1079_CR157) 2018; 38
Y Shin (1079_CR45) 2019; 6
MW Brightman (1079_CR64) 1973; 152
B Marty (1079_CR81) 2012; 32
R Ito (1079_CR59) 2019; 16
LG Remsen (1079_CR67) 1999; 88
DS Hersh (1079_CR88) 2018; 13
FG Avci (1079_CR93) 2018; 8
ND Sheybani (1079_CR85) 2021; 331
SI Rapoport (1079_CR61) 1980; 238
SR Burks (1079_CR91) 2021; 118
A Kalani (1079_CR9) 2014; 34
CD Arvanitis (1079_CR110) 2018; 115
CA Trujillo (1079_CR28) 2019; 25
L Pellegrini (1079_CR26) 2020; 369
S Alli (1079_CR87) 2018; 281
R Kalluri (1079_CR143) 2020; 367
P Eser Ocak (1079_CR14) 2020; 326
W Wang (1079_CR94) 2021; 23
CK Moseley (1079_CR135) 2012; 14
SI Rapoport (1079_CR62) 1971; 173
HJ McCrea (1079_CR122) 2021; 28
TP Buzhdygan (1079_CR40) 2020; 146
KT Chen (1079_CR101) 2019; 10
WM Pardridge (1079_CR131) 2012; 32
TE Park (1079_CR47) 2019; 10
LP Ganipineni (1079_CR21) 2018; 281
B Xiong (1079_CR99) 2021; 64
M Aryal (1079_CR108) 2015; 204
PF D'Haese (1079_CR96) 2020; 14
CP Foley (1079_CR72) 2014; 196
CF Bennett (1079_CR150) 2019; 42
RH Andres (1079_CR164) 2011; 42
M Kinoshita (1079_CR103) 2006; 103
R Deane (1079_CR5) 2009; 29
B Engelhardt (1079_CR154) 2008; 274
O Ham (1079_CR36) 2020; 521
S Joshi (1079_CR68) 2011; 104
RJ Diaz (1079_CR107) 2014; 10
C Chu (1079_CR70) 2020; 317
HJ Wei (1079_CR84) 2021; 110
R Huang (1079_CR127) 2020; 10
X Gu (1079_CR11) 2022; 229
GC Terstappen (1079_CR139) 2021; 20
SWL Lee (1079_CR57) 2020; 9
LL Muldoon (1079_CR66) 1995; 147
SH Park (1079_CR117) 2020; 134
V Dodson (1079_CR30) 2019; 125
J Godinho-Pereira (1079_CR15) 2021; 22
WA Banks (1079_CR137) 2019; 11
DB Vieira (1079_CR142) 2016; 11
PS Steeg (1079_CR151) 2021; 18
O Betzer (1079_CR140) 2017; 12
WG Mayhan (1079_CR76) 1999; 276
SI Rapoport (1079_CR89) 1970; 219
J Aparicio-Blanco (1079_CR48) 2019; 16
Y Xiang (1079_CR27) 2019; 24
JS Rechberger (1079_CR126) 2021; 13
A Herland (1079_CR23) 2016; 11
C Simonneau (1079_CR33) 2021; 18
L Faltings (1079_CR128) 2019; 131
G Sarkar (1079_CR73) 2011; 6
R Mooney (1079_CR147) 2018; 7
M Gorelik (1079_CR156) 2012; 265
WG Lesniak (1079_CR71) 2019; 60
LH Treat (1079_CR83) 2007; 121
M Xiao (1079_CR42) 2020; 14
G Sarkar (1079_CR74) 2014; 9
O Jacobson (1079_CR136) 2015; 26
R Versele (1079_CR46) 2020; 21
L Kalkowski (1079_CR79) 2022; 17
RM Linville (1079_CR75) 2021; 275
ELJ Moya (1079_CR55) 2021; 13
B Cakir (1079_CR37) 2019; 16
JF Jordão (1079_CR104) 2010; 5
A Ahmad (1079_CR44) 2020; 57
WG Lesniak (1079_CR92) 2019; 46
ME Katt (1079_CR6) 2019; 16
S Liebner (1079_CR17) 2018; 135
E Thévenot (1079_CR106) 2012; 23
R Guzman (1079_CR161) 2008; 39
M Janowski (1079_CR69) 2016; 36
RM Linville (1079_CR60) 2019; 190–191
W Lang (1079_CR134) 2020; 10
Y Nashimoto (1079_CR38) 2017; 9
M Kinoshita (1079_CR82) 2006; 340
SI Rapoport (1079_CR63) 1972; 176
SJ Chung (1079_CR123) 2021; 2021
L Dion-Albert (1079_CR1) 2022; 65
DM van Assema (1079_CR8) 2012; 2
U Marx (1079_CR19) 2020; 37
P Arranz-Gibert (1079_CR51) 2019; 9
S Wellens (1079_CR52) 2021; 73
B Engelhardt (1079_CR16) 2014; 355
A Amiri (1079_CR25) 2018; 362
CJ Bachmeier (1079_CR50) 2011; 18
JM Fischell (1079_CR125) 2021; 15
K Boyé (1079_CR18) 2022; 13
A Bunevicius (1079_CR109) 2020; 19
M Zawadzki (1079_CR129) 2019; 12
NV Patel (1079_CR124) 2021; 155
M Sasaki (1079_CR78) 2010; 58
T Adamus (1079_CR148) 2022; 27
JD French (1079_CR119) 1952; 9
Y Ahn (1079_CR35) 2021; 10
RL Dedrick (1079_CR120) 1988; 80
T Sun (1079_CR86) 2021; 336
X Zhao (1079_CR10) 2021; 17
N Lipsman (1079_CR116) 2018; 9
L Paun (1079_CR114) 2021; 13
Z Pi (1079_CR112) 2019; 47
M Nowak (1079_CR141) 2020; 5
YT Sui (1079_CR2) 2014; 62
WA Banks (1079_CR3) 2017; 55
A Da Silva-Candal (1079_CR41) 2019; 309
NI Mansor (1079_CR98) 2019; 16
T Mainprize (1079_CR115) 2019; 9
R Dal Magro (1079_CR152) 2017; 249
S Jiang (1079_CR77) 2014; 9
AD Wong (1079_CR130) 2013; 6
A Nowakowski (1079_CR163) 2017; 7
MA Rizzuto (1079_CR54) 2021; 9
J Deng (1079_CR12) 2012; 46
H Wang (1079_CR7) 2021; 12
JL Mantle (1079_CR49) 2019; 116
A Williams-Medina (1079_CR100) 2020; 2
H Clevers (1079_CR24) 2016; 165
S Lakkadwala (1079_CR56) 2019; 173
S Brunner (1079_CR159) 2013; 108
M Gavina (1079_CR90) 2006; 108
A Andrzejewska (1079_CR162) 2020; 10
DT Connolly (1079_CR95) 1991; 47
Y Wang (1079_CR132) 2019; 9
GL Roux (1079_CR22) 2019; 9
N McDannold (1079_CR111) 2019; 9
H Jin (1079_CR160) 2006; 116
D Rao (1079_CR146) 2021; 9
A Burgess (1079_CR105) 2011; 6
JN Cooke (1079_CR121) 2016; 6
EA Neuwelt (1079_CR65) 1980; 7
K Hynynen (1079_CR80) 2005; 24
BN Rome (1079_CR138) 2021; 109
M Zhao (1079_CR29) 2018; 548
JB Wang (1079_CR102) 2020; 14
F Plisson (1079_CR133) 2019; 17
References_xml – volume: 27
  start-page: 611
  year: 2022
  ident: 1079_CR148
  publication-title: Mol Ther Nucleic Acids
  doi: 10.1016/j.omtn.2021.12.029
– volume: 29
  start-page: 25
  issue: 1
  year: 2009
  ident: 1079_CR5
  publication-title: J Cereb Blood Flow Metab
  doi: 10.1038/jcbfm.2008.117
– volume: 23
  start-page: 63
  issue: 1
  year: 2021
  ident: 1079_CR94
  publication-title: Neuro Oncol
  doi: 10.1093/neuonc/noaa206
– volume: 55
  start-page: 411
  issue: 1
  year: 2017
  ident: 1079_CR3
  publication-title: J Alzheimer's Dis
  doi: 10.3233/JAD-160542
– volume: 521
  start-page: 84
  issue: 1
  year: 2020
  ident: 1079_CR36
  publication-title: Biochem Biophys Res Commun
  doi: 10.1016/j.bbrc.2019.10.079
– volume: 125
  start-page: 511
  year: 2019
  ident: 1079_CR30
  publication-title: World Neurosurg
  doi: 10.1016/j.wneu.2019.01.103
– volume: 331
  start-page: 19
  year: 2021
  ident: 1079_CR85
  publication-title: J Control Release
  doi: 10.1016/j.jconrel.2021.01.023
– volume: 9
  year: 2021
  ident: 1079_CR146
  publication-title: Front Bioeng Biotechnol
  doi: 10.3389/fbioe.2021.797359
– volume: 16
  start-page: 786
  issue: 2
  year: 2019
  ident: 1079_CR153
  publication-title: Mol Pharm
  doi: 10.1021/acs.molpharmaceut.8b01056
– volume: 10
  start-page: 1443
  year: 2020
  ident: 1079_CR127
  publication-title: Front Oncol
  doi: 10.3389/fonc.2020.01443
– volume: 367
  issue: 6478
  year: 2020
  ident: 1079_CR143
  publication-title: Science
  doi: 10.1126/science.aau6977
– volume: 165
  start-page: 1586
  issue: 7
  year: 2016
  ident: 1079_CR24
  publication-title: Cell
  doi: 10.1016/j.cell.2016.05.082
– volume: 10
  start-page: 6615
  issue: 15
  year: 2020
  ident: 1079_CR162
  publication-title: Theranostics
  doi: 10.7150/thno.43169
– volume: 16
  start-page: 4461
  issue: 11
  year: 2019
  ident: 1079_CR59
  publication-title: Mol Pharm
  doi: 10.1021/acs.molpharmaceut.9b00519
– volume: 12
  year: 2021
  ident: 1079_CR97
  publication-title: Front Neurol
  doi: 10.3389/fneur.2021.749047
– volume: 9
  start-page: 6117
  issue: 1
  year: 2019
  ident: 1079_CR132
  publication-title: Sci Rep
  doi: 10.1038/s41598-019-42272-0
– volume: 116
  start-page: 1752
  issue: 7
  year: 2019
  ident: 1079_CR49
  publication-title: Biotechnol Bioeng
  doi: 10.1002/bit.26967
– volume: 255
  start-page: 415
  issue: 2
  year: 2010
  ident: 1079_CR113
  publication-title: Radiology
  doi: 10.1148/radiol.10090699
– volume: 196
  start-page: 71
  year: 2014
  ident: 1079_CR72
  publication-title: J Control Release
  doi: 10.1016/j.jconrel.2014.09.018
– volume: 121
  start-page: 901
  issue: 4
  year: 2007
  ident: 1079_CR83
  publication-title: Int J Cancer
  doi: 10.1002/ijc.22732
– volume: 115
  start-page: E8717
  issue: 37
  year: 2018
  ident: 1079_CR110
  publication-title: Proc Natl Acad Sci USA
  doi: 10.1073/pnas.1807105115
– volume: 62
  start-page: 197
  year: 2014
  ident: 1079_CR2
  publication-title: Peptides
  doi: 10.1016/j.peptides.2014.09.018
– volume: 7
  start-page: 36
  issue: 1
  year: 1980
  ident: 1079_CR65
  publication-title: Neurosurgery
  doi: 10.1227/00006123-198007000-00006
– volume: 46
  start-page: 1940
  issue: 9
  year: 2019
  ident: 1079_CR92
  publication-title: Eur J Nucl Med Mol Imaging
  doi: 10.1007/s00259-019-04347-y
– volume: 108
  start-page: 388
  issue: 6
  year: 2013
  ident: 1079_CR159
  publication-title: Basic Res Cardiol
  doi: 10.1007/s00395-013-0388-3
– volume: 19
  start-page: 9
  issue: 1
  year: 2020
  ident: 1079_CR109
  publication-title: Oper Neurosurg
  doi: 10.1093/ons/opz374
– volume: 152
  start-page: 317
  issue: 4
  year: 1973
  ident: 1079_CR64
  publication-title: J Comp Neurol
  doi: 10.1002/cne.901520402
– volume: 134
  start-page: 1
  year: 2020
  ident: 1079_CR117
  publication-title: J Neurosurg
  doi: 10.3171/2019.11.JNS192224
– volume: 12
  issue: 1
  year: 2019
  ident: 1079_CR129
  publication-title: BMJ case reports
  doi: 10.1136/bcr-2018-014469
– volume: 13
  year: 2020
  ident: 1079_CR4
  publication-title: Front Mol Neurosci
  doi: 10.3389/fnmol.2020.570045
– volume: 6
  start-page: 622
  issue: 5
  year: 2016
  ident: 1079_CR121
  publication-title: Drug Deliv Transl Res
  doi: 10.1007/s13346-016-0319-6
– volume: 131
  start-page: 234
  year: 2019
  ident: 1079_CR128
  publication-title: World Neurosurg
  doi: 10.1016/j.wneu.2019.07.137
– volume: 37
  start-page: 365
  issue: 3
  year: 2020
  ident: 1079_CR19
  publication-title: Altex
– volume: 309
  start-page: 94
  year: 2019
  ident: 1079_CR41
  publication-title: J Control Release
  doi: 10.1016/j.jconrel.2019.07.026
– volume: 88
  start-page: 559
  issue: 3
  year: 1999
  ident: 1079_CR67
  publication-title: Anesth Analg
– volume: 11
  start-page: 5381
  year: 2016
  ident: 1079_CR142
  publication-title: Int J Nanomed
  doi: 10.2147/IJN.S117210
– volume: 13
  start-page: 1169
  issue: 1
  year: 2022
  ident: 1079_CR18
  publication-title: Nat Commun
  doi: 10.1038/s41467-022-28785-9
– volume: 146
  year: 2020
  ident: 1079_CR40
  publication-title: Neurobiol Dis
  doi: 10.1016/j.nbd.2020.105131
– volume: 9
  start-page: 2336
  issue: 1
  year: 2018
  ident: 1079_CR116
  publication-title: Nat Commun
  doi: 10.1038/s41467-018-04529-6
– volume: 11
  start-page: 489
  issue: 6
  year: 2019
  ident: 1079_CR137
  publication-title: Future Med Chem
  doi: 10.4155/fmc-2018-0436
– volume: 317
  start-page: 312
  year: 2020
  ident: 1079_CR70
  publication-title: J Control Release
  doi: 10.1016/j.jconrel.2019.11.019
– volume: 268
  start-page: 364
  year: 2017
  ident: 1079_CR31
  publication-title: J Control Release
  doi: 10.1016/j.jconrel.2017.09.001
– volume: 9
  start-page: 4875
  issue: 1
  year: 2019
  ident: 1079_CR51
  publication-title: Sci Rep
  doi: 10.1038/s41598-019-40973-0
– volume: 10
  start-page: 86
  year: 2019
  ident: 1079_CR101
  publication-title: Front Pharmacol
  doi: 10.3389/fphar.2019.00086
– volume: 297
  start-page: 1113
  issue: 3
  year: 2001
  ident: 1079_CR149
  publication-title: J Pharmacol Exp Ther
– volume: 173
  start-page: 1026
  issue: 4001
  year: 1971
  ident: 1079_CR62
  publication-title: Science
  doi: 10.1126/science.173.4001.1026
– volume: 9
  issue: 5
  year: 2014
  ident: 1079_CR74
  publication-title: PLoS ONE
  doi: 10.1371/journal.pone.0097655
– volume: 17
  issue: 1
  year: 2022
  ident: 1079_CR79
  publication-title: PLoS ONE
  doi: 10.1371/journal.pone.0262677
– volume: 204
  start-page: 60
  year: 2015
  ident: 1079_CR108
  publication-title: J Control Release
  doi: 10.1016/j.jconrel.2015.02.033
– volume: 13
  start-page: 1885
  issue: 11
  year: 2021
  ident: 1079_CR126
  publication-title: Pharmaceutics
  doi: 10.3390/pharmaceutics13111885
– volume: 6
  start-page: 7
  year: 2013
  ident: 1079_CR130
  publication-title: Front Neuroeng
  doi: 10.3389/fneng.2013.00007
– volume: 80
  start-page: 84
  issue: 2
  year: 1988
  ident: 1079_CR120
  publication-title: J Natl Cancer Inst
  doi: 10.1093/jnci/80.2.84
– volume: 42
  start-page: 2923
  issue: 10
  year: 2011
  ident: 1079_CR164
  publication-title: Stroke
  doi: 10.1161/STROKEAHA.110.606368
– volume: 135
  start-page: 311
  issue: 3
  year: 2018
  ident: 1079_CR17
  publication-title: Acta Neuropathol
  doi: 10.1007/s00401-018-1815-1
– volume: 24
  start-page: 12
  issue: 1
  year: 2005
  ident: 1079_CR80
  publication-title: Neuroimage
  doi: 10.1016/j.neuroimage.2004.06.046
– volume: 36
  start-page: 569
  issue: 3
  year: 2016
  ident: 1079_CR69
  publication-title: J Cereb Blood Flow Metab
  doi: 10.1177/0271678X15615875
– volume: 2021
  start-page: 9886877
  year: 2021
  ident: 1079_CR123
  publication-title: Stem Cells Int
  doi: 10.1155/2021/9886877
– volume: 58
  start-page: 1523
  issue: 13
  year: 2010
  ident: 1079_CR78
  publication-title: Glia
  doi: 10.1002/glia.21026
– volume: 29
  start-page: 341
  issue: 4
  year: 2011
  ident: 1079_CR144
  publication-title: Nat Biotechnol
  doi: 10.1038/nbt.1807
– volume: 109
  start-page: 367
  issue: 2
  year: 2021
  ident: 1079_CR138
  publication-title: Clin Pharmacol Ther
  doi: 10.1002/cpt.1983
– volume: 143
  start-page: e254
  issue: 8
  year: 2021
  ident: 1079_CR43
  publication-title: Circulation
  doi: 10.1161/CIR.0000000000000950
– volume: 16
  start-page: 1999
  issue: 5
  year: 2019
  ident: 1079_CR48
  publication-title: Mol Pharm
  doi: 10.1021/acs.molpharmaceut.8b01344
– volume: 147
  start-page: 1840
  issue: 6
  year: 1995
  ident: 1079_CR66
  publication-title: Am J Pathol
– volume: 64
  start-page: 13152
  issue: 18
  year: 2021
  ident: 1079_CR99
  publication-title: J Med Chem
  doi: 10.1021/acs.jmedchem.1c00910
– volume: 2
  start-page: 57
  issue: 1
  year: 2012
  ident: 1079_CR8
  publication-title: EJNMMI Res
  doi: 10.1186/2191-219X-2-57
– volume: 21
  start-page: 934
  issue: 3
  year: 2020
  ident: 1079_CR46
  publication-title: Int J Mol Sci
  doi: 10.3390/ijms21030934
– volume: 46
  start-page: 677
  issue: 3
  year: 2012
  ident: 1079_CR12
  publication-title: J Mol Neurosci
  doi: 10.1007/s12031-011-9629-9
– volume: 336
  start-page: 443
  year: 2021
  ident: 1079_CR86
  publication-title: J Control Release
  doi: 10.1016/j.jconrel.2021.06.037
– volume: 281
  start-page: 29
  year: 2018
  ident: 1079_CR87
  publication-title: J Control Release
  doi: 10.1016/j.jconrel.2018.05.005
– volume: 9
  start-page: 2032
  issue: 6
  year: 2021
  ident: 1079_CR54
  publication-title: Biomater Sci
  doi: 10.1039/D0BM01726D
– volume: 14
  start-page: 5872
  issue: 23
  year: 2012
  ident: 1079_CR135
  publication-title: Org Lett
  doi: 10.1021/ol302791x
– volume: 326
  year: 2020
  ident: 1079_CR14
  publication-title: Exp Neurol
  doi: 10.1016/j.expneurol.2020.113203
– volume: 117
  start-page: 9180
  issue: 17
  year: 2020
  ident: 1079_CR118
  publication-title: Proc Natl Acad Sci USA
  doi: 10.1073/pnas.2002571117
– volume: 38
  start-page: 835
  issue: 5
  year: 2018
  ident: 1079_CR157
  publication-title: J Cereb Blood Flow Metab
  doi: 10.1177/0271678X17703888
– volume: 4
  start-page: 863
  issue: 9
  year: 2020
  ident: 1079_CR34
  publication-title: Nat Biomed Eng
  doi: 10.1038/s41551-020-0565-2
– volume: 16
  start-page: 20
  issue: 1
  year: 2019
  ident: 1079_CR6
  publication-title: Fluids Barriers CNS
  doi: 10.1186/s12987-019-0139-4
– volume: 155
  start-page: 117
  issue: 2
  year: 2021
  ident: 1079_CR124
  publication-title: J Neurooncol
  doi: 10.1007/s11060-021-03851-2
– volume: 355
  start-page: 687
  issue: 3
  year: 2014
  ident: 1079_CR16
  publication-title: Cell Tissue Res
  doi: 10.1007/s00441-014-1811-2
– volume: 281
  start-page: 42
  year: 2018
  ident: 1079_CR21
  publication-title: J Control Release
  doi: 10.1016/j.jconrel.2018.05.008
– volume: 118
  issue: 18
  year: 2021
  ident: 1079_CR91
  publication-title: Proc Natl Acad Sci USA
  doi: 10.1073/pnas.2021915118
– volume: 6
  start-page: 1900962
  issue: 20
  year: 2019
  ident: 1079_CR45
  publication-title: Adv Sci
  doi: 10.1002/advs.201900962
– volume: 10
  start-page: 1075
  issue: 5
  year: 2014
  ident: 1079_CR107
  publication-title: Nanomed Nanotechnol Biol Med
  doi: 10.1016/j.nano.2013.12.006
– volume: 173
  start-page: 27
  year: 2019
  ident: 1079_CR56
  publication-title: Colloids Surf, B
  doi: 10.1016/j.colsurfb.2018.09.047
– volume: 275
  year: 2021
  ident: 1079_CR75
  publication-title: Biomaterials
  doi: 10.1016/j.biomaterials.2021.120942
– volume: 60
  start-page: 617
  issue: 5
  year: 2019
  ident: 1079_CR71
  publication-title: J Nuclear Med
  doi: 10.2967/jnumed.118.218792
– volume: 11
  start-page: 33637
  issue: 37
  year: 2019
  ident: 1079_CR39
  publication-title: ACS Appl Mater Interfaces
  doi: 10.1021/acsami.9b10787
– volume: 3
  start-page: 8
  year: 2018
  ident: 1079_CR32
  publication-title: NPJ Regener Med
  doi: 10.1038/s41536-018-0046-3
– volume: 9
  start-page: 16310
  issue: 1
  year: 2019
  ident: 1079_CR22
  publication-title: Sci Rep
  doi: 10.1038/s41598-019-52213-6
– volume: 73
  year: 2021
  ident: 1079_CR52
  publication-title: Toxic In Vitro
  doi: 10.1016/j.tiv.2021.105112
– volume: 369
  issue: 6500
  year: 2020
  ident: 1079_CR26
  publication-title: Science
  doi: 10.1126/science.aaz5626
– volume: 9
  start-page: 506
  issue: 6
  year: 2017
  ident: 1079_CR38
  publication-title: Integr Biol
  doi: 10.1039/C7IB00024C
– volume: 9
  issue: 7
  year: 2020
  ident: 1079_CR57
  publication-title: Adv Healthcare Mater
  doi: 10.1002/adhm.201901486
– volume: 120
  start-page: 1368
  issue: 5
  year: 2010
  ident: 1079_CR155
  publication-title: J Clin Investig
  doi: 10.1172/JCI41911
– volume: 14
  start-page: 764
  year: 2020
  ident: 1079_CR42
  publication-title: Front Neurosci
  doi: 10.3389/fnins.2020.00764
– volume: 103
  start-page: 11719
  issue: 31
  year: 2006
  ident: 1079_CR103
  publication-title: Proc Natl Acad Sci USA
  doi: 10.1073/pnas.0604318103
– volume: 274
  start-page: 23
  issue: 1–2
  year: 2008
  ident: 1079_CR154
  publication-title: J Neurol Sci
  doi: 10.1016/j.jns.2008.05.019
– volume: 8
  start-page: 77
  issue: 3
  year: 2018
  ident: 1079_CR93
  publication-title: Biomolecules
  doi: 10.3390/biom8030077
– volume: 17
  start-page: 81
  issue: 2
  year: 2019
  ident: 1079_CR133
  publication-title: Mar Drugs
  doi: 10.3390/md17020081
– volume: 30
  start-page: 994
  issue: 4
  year: 2019
  ident: 1079_CR145
  publication-title: Bioconjug Chem
  doi: 10.1021/acs.bioconjchem.9b00085
– volume: 20
  start-page: 362
  issue: 5
  year: 2021
  ident: 1079_CR139
  publication-title: Nat Rev Drug Discov
  doi: 10.1038/s41573-021-00139-y
– volume: 340
  start-page: 1085
  issue: 4
  year: 2006
  ident: 1079_CR82
  publication-title: Biochem Biophys Res Commun
  doi: 10.1016/j.bbrc.2005.12.112
– volume: 110
  start-page: 539
  issue: 2
  year: 2021
  ident: 1079_CR84
  publication-title: Int J Radiat Oncol Biol Phys
  doi: 10.1016/j.ijrobp.2020.12.019
– volume: 7
  start-page: 1103
  issue: 1
  year: 2017
  ident: 1079_CR163
  publication-title: Sci Rep
  doi: 10.1038/s41598-017-01304-3
– volume: 18
  start-page: 373
  issue: 5
  year: 2011
  ident: 1079_CR50
  publication-title: Microcirculation
  doi: 10.1111/j.1549-8719.2011.00096.x
– volume: 108
  start-page: 2857
  issue: 8
  year: 2006
  ident: 1079_CR90
  publication-title: Blood
– volume: 57
  start-page: 4373
  issue: 11
  year: 2020
  ident: 1079_CR44
  publication-title: Mol Neurobiol
  doi: 10.1007/s12035-020-02023-z
– volume: 276
  start-page: C1148
  issue: 5
  year: 1999
  ident: 1079_CR76
  publication-title: Am J Physiol
  doi: 10.1152/ajpcell.1999.276.5.C1148
– volume: 219
  start-page: 270
  issue: 1
  year: 1970
  ident: 1079_CR89
  publication-title: Am J Physiol
  doi: 10.1152/ajplegacy.1970.219.1.270
– volume: 32
  start-page: 1959
  issue: 11
  year: 2012
  ident: 1079_CR131
  publication-title: J Cereb Blood Flow Metab
  doi: 10.1038/jcbfm.2012.126
– volume: 12
  start-page: 1533
  issue: 13
  year: 2017
  ident: 1079_CR140
  publication-title: Nanomedicine
  doi: 10.2217/nnm-2017-0022
– volume: 229
  year: 2022
  ident: 1079_CR11
  publication-title: Eur J Med Chem
  doi: 10.1016/j.ejmech.2021.114090
– volume: 18
  start-page: 696
  issue: 11
  year: 2021
  ident: 1079_CR151
  publication-title: Nat Rev Clin Oncol
  doi: 10.1038/s41571-021-00529-6
– volume: 22
  start-page: 7057
  issue: 13
  year: 2021
  ident: 1079_CR15
  publication-title: Int J Mol Sci
  doi: 10.3390/ijms22137057
– volume: 2
  year: 2020
  ident: 1079_CR100
  publication-title: Front Med Technol
  doi: 10.3389/fmedt.2020.623950
– volume: 9
  start-page: 6284
  issue: 21
  year: 2019
  ident: 1079_CR111
  publication-title: Theranostics
  doi: 10.7150/thno.35892
– volume: 14
  year: 2020
  ident: 1079_CR96
  publication-title: Front Hum Neurosci
  doi: 10.3389/fnhum.2020.593672
– volume: 10
  start-page: 2036
  issue: 8
  year: 2021
  ident: 1079_CR35
  publication-title: Cells
  doi: 10.3390/cells10082036
– volume: 5
  issue: 2
  year: 2020
  ident: 1079_CR141
  publication-title: Bioeng Transl Med
  doi: 10.1002/btm2.10153
– volume: 26
  start-page: 754
  issue: 3
  year: 2021
  ident: 1079_CR20
  publication-title: Drug Discov Today
  doi: 10.1016/j.drudis.2020.11.009
– volume: 32
  start-page: 1948
  issue: 10
  year: 2012
  ident: 1079_CR81
  publication-title: J Cereb Blood Flow Metab
  doi: 10.1038/jcbfm.2012.100
– volume: 176
  start-page: 1243
  issue: 4040
  year: 1972
  ident: 1079_CR63
  publication-title: Science
  doi: 10.1126/science.176.4040.1243
– volume: 16
  start-page: 1169
  issue: 11
  year: 2019
  ident: 1079_CR37
  publication-title: Nat Methods
  doi: 10.1038/s41592-019-0586-5
– volume: 16
  start-page: 698
  issue: 8
  year: 2019
  ident: 1079_CR98
  publication-title: Curr Drug Deliv
  doi: 10.2174/1567201816666190828153017
– volume: 25
  start-page: 558
  issue: 4
  year: 2019
  ident: 1079_CR28
  publication-title: Cell Stem Cell
  doi: 10.1016/j.stem.2019.08.002
– volume: 39
  start-page: 1300
  issue: 4
  year: 2008
  ident: 1079_CR161
  publication-title: Stroke
  doi: 10.1161/STROKEAHA.107.500470
– volume: 11
  issue: 3
  year: 2016
  ident: 1079_CR23
  publication-title: PLoS ONE
  doi: 10.1371/journal.pone.0150360
– volume: 24
  start-page: 487
  issue: 3
  year: 2019
  ident: 1079_CR27
  publication-title: Cell Stem Cell
  doi: 10.1016/j.stem.2018.12.015
– volume: 40
  start-page: 1517
  issue: 7
  year: 2020
  ident: 1079_CR53
  publication-title: J Cerebr Blood Flow Metab
  doi: 10.1177/0271678X19867980
– volume: 28
  start-page: 371
  issue: 4
  year: 2021
  ident: 1079_CR122
  publication-title: J Neurosurg Pediatr
  doi: 10.3171/2021.3.PEDS20738
– volume: 6
  issue: 12
  year: 2011
  ident: 1079_CR73
  publication-title: PLoS ONE
  doi: 10.1371/journal.pone.0028881
– volume: 190–191
  start-page: 24
  year: 2019
  ident: 1079_CR60
  publication-title: Biomaterials
  doi: 10.1016/j.biomaterials.2018.10.023
– volume: 249
  start-page: 103
  year: 2017
  ident: 1079_CR152
  publication-title: J Control Release
  doi: 10.1016/j.jconrel.2017.01.039
– volume: 26
  start-page: 1
  issue: 1
  year: 2015
  ident: 1079_CR136
  publication-title: Bioconjug Chem
  doi: 10.1021/bc500475e
– volume: 13
  start-page: 892
  issue: 6
  year: 2021
  ident: 1079_CR55
  publication-title: Pharmaceutics
  doi: 10.3390/pharmaceutics13060892
– volume: 23
  start-page: 1144
  issue: 11
  year: 2012
  ident: 1079_CR106
  publication-title: Hum Gene Ther
  doi: 10.1089/hum.2012.013
– volume: 17
  start-page: 712
  issue: 3
  year: 2021
  ident: 1079_CR10
  publication-title: Int J Biol Sci
  doi: 10.7150/ijbs.45885
– volume: 15
  year: 2021
  ident: 1079_CR125
  publication-title: Front Neurosci
  doi: 10.3389/fnins.2021.747726
– volume: 10
  start-page: 434
  issue: 5
  year: 2020
  ident: 1079_CR134
  publication-title: J Pharm Anal
  doi: 10.1016/j.jpha.2020.08.006
– volume: 13
  start-page: 5614
  issue: 22
  year: 2021
  ident: 1079_CR114
  publication-title: Cancers
  doi: 10.3390/cancers13225614
– volume: 116
  start-page: 652
  issue: 3
  year: 2006
  ident: 1079_CR160
  publication-title: J Clin Investig
  doi: 10.1172/JCI24751
– volume: 548
  start-page: 522
  issue: 1
  year: 2018
  ident: 1079_CR29
  publication-title: Int J Pharm
  doi: 10.1016/j.ijpharm.2018.07.033
– volume: 9
  issue: 2
  year: 2014
  ident: 1079_CR77
  publication-title: PLoS ONE
  doi: 10.1371/journal.pone.0086407
– volume: 5
  issue: 5
  year: 2010
  ident: 1079_CR104
  publication-title: PLoS ONE
  doi: 10.1371/journal.pone.0010549
– volume: 9
  start-page: 321
  issue: 1
  year: 2019
  ident: 1079_CR115
  publication-title: Sci Rep
  doi: 10.1038/s41598-018-36340-0
– volume: 8
  start-page: 200
  issue: 1
  year: 2019
  ident: 1079_CR58
  publication-title: BioResearch Open Access
  doi: 10.1089/biores.2019.0026
– volume: 13
  issue: 2
  year: 2018
  ident: 1079_CR88
  publication-title: PLoS ONE
  doi: 10.1371/journal.pone.0192240
– volume: 6
  issue: 11
  year: 2011
  ident: 1079_CR105
  publication-title: PLoS ONE
  doi: 10.1371/journal.pone.0027877
– volume: 65
  year: 2022
  ident: 1079_CR1
  publication-title: Front Neuroendocrinol
  doi: 10.1016/j.yfrne.2022.100989
– volume: 265
  start-page: 175
  issue: 1
  year: 2012
  ident: 1079_CR156
  publication-title: Radiology
  doi: 10.1148/radiol.12112212
– volume: 34
  start-page: 1212
  issue: 7
  year: 2014
  ident: 1079_CR9
  publication-title: J Cereb Blood Flow Metab
  doi: 10.1038/jcbfm.2014.74
– volume: 12
  start-page: 4826
  issue: 1
  year: 2021
  ident: 1079_CR7
  publication-title: Nat Commun
  doi: 10.1038/s41467-021-25157-7
– volume: 42
  start-page: 385
  year: 2019
  ident: 1079_CR150
  publication-title: Annu Rev Neurosci
  doi: 10.1146/annurev-neuro-070918-050501
– volume: 25
  start-page: 247
  issue: 2
  year: 2014
  ident: 1079_CR13
  publication-title: Rev Neurosci
  doi: 10.1515/revneuro-2013-0039
– volume: 9
  start-page: 378
  issue: 4
  year: 1952
  ident: 1079_CR119
  publication-title: J Neurosurg
  doi: 10.3171/jns.1952.9.4.0378
– volume: 7
  start-page: 740
  issue: 10
  year: 2018
  ident: 1079_CR147
  publication-title: Stem Cells Transl Med
  doi: 10.1002/sctm.18-0003
– volume: 10
  start-page: 2621
  issue: 1
  year: 2019
  ident: 1079_CR47
  publication-title: Nat Commun
  doi: 10.1038/s41467-019-10588-0
– volume: 47
  start-page: 219
  issue: 3
  year: 1991
  ident: 1079_CR95
  publication-title: J Cell Biochem
  doi: 10.1002/jcb.240470306
– volume: 39
  start-page: 2308
  issue: 11
  year: 2019
  ident: 1079_CR158
  publication-title: J Cereb Blood Flow Metab
  doi: 10.1177/0271678X18805238
– volume: 362
  issue: 6420
  year: 2018
  ident: 1079_CR25
  publication-title: Science
  doi: 10.1126/science.aat6720
– volume: 238
  start-page: R421
  issue: 5
  year: 1980
  ident: 1079_CR61
  publication-title: Am J Physiol
– volume: 104
  start-page: 11
  issue: 1
  year: 2011
  ident: 1079_CR68
  publication-title: J Neurooncol
  doi: 10.1007/s11060-010-0466-4
– volume: 47
  start-page: 549
  issue: 2
  year: 2019
  ident: 1079_CR112
  publication-title: Ann Biomed Eng
  doi: 10.1007/s10439-018-02141-9
– volume: 14
  start-page: 675
  year: 2020
  ident: 1079_CR102
  publication-title: Front Neurosci
  doi: 10.3389/fnins.2020.00675
– volume: 18
  start-page: 43
  issue: 1
  year: 2021
  ident: 1079_CR33
  publication-title: Fluids Barriers CNS
  doi: 10.1186/s12987-021-00276-x
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Snippet The bloodâ brain barrier (BBB) is a sophisticated structure whose full functionality is required for maintaining the executive functions of the central nervous...
The blood–brain barrier (BBB) is a sophisticated structure whose full functionality is required for maintaining the executive functions of the central nervous...
The blood-brain barrier (BBB) is a sophisticated structure whose full functionality is required for maintaining the executive functions of the central nervous...
Abstract The blood–brain barrier (BBB) is a sophisticated structure whose full functionality is required for maintaining the executive functions of the central...
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SubjectTerms BBB
Blood-brain barrier
Brain
Brain cancer
Brain research
Central nervous system
Drug delivery
Drug delivery systems
Drug targets
Drugs
Focused ultrasound
Gender differences
In vitro models
In vivo models
Kinases
Metastases
Mutation
Nervous system diseases
Neurological diseases
Organoid models
Permeability
Proteins
Review
Vehicles
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Title Cutting-edge advances in modeling the blood–brain barrier and tools for its reversible permeabilization for enhanced drug delivery into the brain
URI http://hdl.handle.net/1822/85825
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Volume 13
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