An in vivo genetic reversion highlights the crucial role of Myb-Like, SWIRM, and MPN domains 1 (MYSM1) in human hematopoiesis and lymphocyte differentiation

• Published in: Journal of allergy and clinical immunology Vol. 136; no. 6; pp. 1619 - 1626.e5
• Main Authors: Le Guen, Tangui, Touzot, Fabien, André-Schmutz, Isabelle, Lagresle-Peyrou, Chantal, France, Benoit, Kermasson, Laetitia, Lambert, Nathalie, Picard, Capucine, Nitschke, Patrick, Carpentier, Wassila, Bole-Feysot, Christine, Lim, Annick, Cavazzana, Marina, Callebaut, Isabelle, Soulier, Jean, Jabado, Nada, Fischer, Alain, de Villartay, Jean-Pierre, Revy, Patrick
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.12.2015; Elsevier Limited; Elsevier
• Subjects: Allergy and Immunology; B-Lymphocytes - cytology; Bone marrow; Cell Differentiation; Deoxyribonucleic acid; DNA; DNA methylation; DNA-Binding Proteins - genetics; Epigenetics; Gene expression; genetic reversion; Genomes; Hematopoiesis; Hematopoiesis - genetics; histone deubiquitinase; Humans; immunodeficiency; Immunoglobulins; Immunologic Deficiency Syndromes - genetics; Infant; Life Sciences; Lymphocytes; Lymphopenia - genetics; Male; Mutation; MYSM1; Proteins; Quality; Software; T-Lymphocytes - cytology; Thermal cycling; Transcription Factors - genetics; KO; MYSM1; genetic reversion; APC; Hematopoiesis; JAMM; PE; H2A; HSC; immunodeficiency; histone deubiquitinase; NK; WGHM; WT; JAB1/MPN/Mov34; Knockout; Wild-type; Histone 2A; Hematopoietic stem cell; Natural killer; Myb-Like, SWIRM, and MPN domains 1; Phycoerythrin; Allophycocyanin; Whole-genome homozygosity mapping

Myb-Like, SWIRM, and MPN domains 1 (MYSM1) is a metalloprotease that deubiquitinates the K119-monoubiquitinated form of histone 2A (H2A), a chromatin marker associated with gene transcription silencing. Likewise, it has been reported that murine Mysm1 participates in transcription derepression of ge...