Inhibition of dengue virus entry and multiplication into monocytes using RNA interference

• Published in: PLoS neglected tropical diseases Vol. 5; no. 11; p. e1410
• Main Authors: Alhoot, Mohammed Abdelfatah, Wang, Seok Mui, Sekaran, Shamala Devi
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 01.11.2011; Public Library of Science (PLoS)
• Subjects: Analysis; Biology; Biomedical research; Blood banks; Blood Donors; Bone marrow; Care and treatment; Cells, Cultured; Clathrin; Clathrin Heavy Chains - antagonists & inhibitors; Clathrin Heavy Chains - genetics; Dengue; Dengue fever; Dengue Virus - pathogenicity; Development and progression; Disease; Dynamin II - antagonists & inhibitors; Dynamin II - genetics; Endocytosis; Fever; Flow cytometry; Gene expression; Gene Silencing; Health aspects; Humans; Infections; Lipopolysaccharide Receptors - genetics; Lipopolysaccharide Receptors - metabolism; Medicine; Monocytes - physiology; Monocytes - virology; Multiplication & division; Physiological aspects; Prevention; Proteins; Public health; RNA Interference; Studies; Tropical diseases; Viral Load; Virus Internalization; Malaysia; California; Dynamin II; Antigens, CD14; Humans; Cells, Cultured; Gene Silencing; Dengue Virus; Viral Load; Virus Internalization; Blood Donors; Endocytosis; Monocytes; RNA Interference; Clathrin Heavy Chains

Dengue infection ranks as one of the most significant viral diseases of the globe. Currently, there is no specific vaccine or antiviral therapy for prevention or treatment. Monocytes/macrophages are the principal target cells for dengue virus and are responsible for disseminating the virus after its...