Precision-guided antimicrobial peptide as a targeted modulator of human microbial ecology

• Published in: Proceedings of the National Academy of Sciences - PNAS Vol. 112; no. 24; pp. 7569 - 7574
• Main Authors: Guo, Lihong, Jeffrey S. McLean, Youngik Yang, Randal Eckert, Christopher W. Kaplan, Pierre Kyme, Omid Sheikh, Brian Varnum, Renate Lux, Wenyuan Shi, Xuesong He
• Format: Journal Article
• Language: English
• Published: United States National Academy of Sciences 16.06.2015; National Acad Sciences
• Subjects: Adult; Anti-Bacterial Agents - pharmacology; anti-infective agents; Antimicrobial agents; Antimicrobial Cationic Peptides - pharmacology; antimicrobial peptides; Biofilms - drug effects; Biofilms - growth & development; Biological Sciences; Dental care; Dental caries; Dental Caries - microbiology; Ecological function; human microbiome; Humans; microbial communities; Microbial Sensitivity Tests; microbiome; Microbiota - drug effects; Mouth - microbiology; oral microbiota; Peptides; Saliva - microbiology; Streptococcus infections; Streptococcus mutans; Streptococcus mutans - drug effects; Streptococcus mutans - pathogenicity; Streptococcus mutans - physiology; targeted antimicrobial; dental caries; human microbiome; oral microbiota; targeted antimicrobial

One major challenge to studying human microbiome and its associated diseases is the lack of effective tools to achieve targeted modulation of individual species and study its ecological function within multispecies communities. Here, we show that C16G2, a specifically targeted antimicrobial peptide,...