ClustScan: an integrated program package for the semi-automatic annotation of modular biosynthetic gene clusters and in silico prediction of novel chemical structures

• Published in: Nucleic acids research Vol. 36; no. 21; pp. 6882 - 6892
• Main Authors: Starcevic, Antonio, Zucko, Jurica, Simunkovic, Jurica, Long, Paul F, Cullum, John, Hranueli, Daslav
• Format: Journal Article
• Language: English
• Published: England Oxford University Press 01.12.2008; Oxford Publishing Limited (England)
• Subjects: Actinobacteria; Animals; Anti-Bacterial Agents - biosynthesis; Anti-Bacterial Agents - chemistry; biochemical pathways; Catalytic Domain; chemical structure; Computational Biology; Computer Graphics; data collection; DNA; Gene Order; Genomics; hybrids; invertebrates; ligases; metagenomics; Models, Molecular; multigene family; nucleotide sequences; Peptide Synthases - chemistry; Peptide Synthases - genetics; polyketide synthases; Polyketide Synthases - chemistry; Polyketide Synthases - genetics; prediction; Sequence Analysis, DNA; Software; stereochemistry; Systems Integration

The program package 'ClustScan' (Cluster Scanner) is designed for rapid, semi-automatic, annotation of DNA sequences encoding modular biosynthetic enzymes including polyketide synthases (PKS), non-ribosomal peptide synthetases (NRPS) and hybrid (PKS/NRPS) enzymes. The program displays the...