Enzymes of the Shikimic Acid Pathway Encoded in the Genome of a Basal Metazoan, Nematostella vectensis, Have Microbial Origins

• Published in: Proceedings of the National Academy of Sciences - PNAS Vol. 105; no. 7; pp. 2533 - 2537
• Main Authors: Starcevic, Antonio, Akthar, Shamima, Dunlap, Walter C., Shick, J. Malcolm, Hranueli, Daslav, Cullum, John, Long, Paul F.
• Format: Journal Article
• Language: English
• Published: United States National Academy of Sciences 19.02.2008; National Acad Sciences
• Subjects: Amino acids; Animals; Anthozoa; Aquatic life; Aromatic compounds; Bacteria; biogenesis; bioinformatics; Biological Sciences; Biosynthesis; Blasts; Cnidaria; Datasets; Dinophyceae; Enzymes; Eukaryotes; Flavobacteriaceae; fungi; genes; Genome - genetics; Genomes; Genomics; Marine; Metabolites; Metazoa; Molecular biology; Nematostella vectensis; nucleotide sequences; Phylogenetics; Phylogeny; Protozoa; ribosomal RNA; Scaffolds; Sea Anemones - classification; Sea Anemones - enzymology; Sea Anemones - genetics; shikimate pathway; shikimic acid; Shikimic Acid - metabolism; symbionts; Symbiosis; Tenacibaculum

The shikimic acid pathway is responsible for the biosynthesis of many aromatic compounds by a broad range of organisms, including bacteria, fungi, plants, and some protozoans. Animals are considered to lack this pathway, as evinced by their dietary requirement for shikimate-derived aromatic amino ac...