Non Susceptibility of Neonatal and Adult Rats against the Middle East Respiratory Syndrome Coronavirus

• Published in: Japanese Journal of Infectious Diseases Vol. 69; no. 6; pp. 510 - 516
• Main Authors: Iwata-Yoshikawa, Naoko, Fukushi, Shuetsu, Fukuma, Aiko, Suzuki, Tadaki, Takeda, Makoto, Tashiro, Masato, Hasegawa, Hideki, Nagata, Noriyo
• Format: Journal Article
• Language: English
• Published: Japan National Institute of Infectious Diseases, Japanese Journal of Infectious Diseases Editorial Committee 2016
• Subjects: Administration, Intranasal; animal model; Animals; Cell Line; Coronaviridae; Disease Resistance; Female; Host Specificity; Humans; Immunohistochemistry; Lung - virology; MERS-CoV; Middle East Respiratory Syndrome Coronavirus - growth & development; Pregnancy; rat; Rats, Inbred F344; Rats, Inbred Lew; susceptibility; Viral Tropism

The present study examined the susceptibility of rats to the Middle East respiratory syndrome coronavirus (MERS-CoV) and determined whether this animal is a suitable model for MERS-CoV infection. Immunohistochemical analysis identified dipeptidyl peptidase 4 (DPP4), a known receptor for MERS-CoV on...