Bromodomain protein BRD4 controls HOTAIR, a long noncoding RNA essential for glioblastoma proliferation

• Published in: Proceedings of the National Academy of Sciences - PNAS Vol. 112; no. 27; pp. 8326 - 8331
• Main Authors: Pastori, Chiara, Philipp Kapranov, Clara Penas, Veronica Peschansky, Claude-Henry Volmar, Jann N. Sarkaria, Amade Bregy, Ricardo Komotar, Georges St. Laurent, Nagi G. Ayad, Claes Wahlestedt
• Format: Journal Article
• Language: English
• Published: United States National Academy of Sciences 07.07.2015; National Acad Sciences
• Subjects: Animals; antisense RNA; Apoptosis - genetics; Biological Sciences; Brain cancer; Brain Neoplasms - genetics; Brain Neoplasms - metabolism; Brain Neoplasms - pathology; BRD4; Cell growth; Cell Line, Tumor; Cell Proliferation - drug effects; Cell Proliferation - genetics; chromatin; clinical trials; Epigenetics; Gene expression; gene expression regulation; Gene Expression Regulation, Neoplastic - drug effects; glioblastoma; Glioblastoma - genetics; Glioblastoma - metabolism; Glioblastoma - pathology; Heterocyclic Compounds, 4 or More Rings - pharmacology; Humans; I-BET151; Inhibitors; long noncoding RNAs; Mice, Nude; Microscopy, Fluorescence; neoplasms; non-coding RNA; Nuclear Proteins - antagonists & inhibitors; Nuclear Proteins - genetics; Nuclear Proteins - metabolism; oncogenes; precipitin tests; Promoter Regions, Genetic - genetics; Protein Binding; Proteins; Reverse Transcriptase Polymerase Chain Reaction; Ribonucleic acid; RNA; RNA Interference; RNA, Long Noncoding - genetics; RNA, Long Noncoding - metabolism; Transcription Factors - antagonists & inhibitors; Transcription Factors - genetics; Transcription Factors - metabolism; Xenograft Model Antitumor Assays - methods; I-BET151; glioblastoma; long noncoding RNAs; epigenetics; BRD4

Bromodomain and extraterminal (BET) domain proteins have emerged as promising therapeutic targets in glioblastoma and many other cancers. Small molecule inhibitors of BET bromodomain proteins reduce expression of several oncogenes required for Glioblastoma Multiforme (GBM) progression. However, the...