Bromodomain protein BRD4 controls HOTAIR, a long noncoding RNA essential for glioblastoma proliferation - Pastori, Chiara; Philipp Kapranov; Clara Penas; Veronica Peschansky; Claude-Henry Volmar; Jann N. Sarkaria; Amade Bregy; Ricardo Komotar; Georges St. Laurent; Nagi G. Ayad; Claes Wahlestedt (Proceedings of the National Academy of Sciences - PNAS, 2015)
Keywords: Animals; antisense RNA; Apoptosis - genetics; Biological Sciences; Brain cancer; Brain Neoplasms - genetics; Brain Neoplasms - metabolism; Brain Neoplasms - pathology; BRD4; Cell growth; Cell Line, Tumor; Cell Proliferation - drug effects; Cell Proliferation - genetics; chromatin; clinical trials; Epigenetics; Gene expression; gene expression regulation; Gene Expression Regulation, Neoplastic - drug effects; glioblastoma; Glioblastoma - genetics; Glioblastoma - metabolism; Glioblastoma - pathology; Heterocyclic Compounds, 4 or More Rings - pharmacology; Humans; I-BET151; Inhibitors; long noncoding RNAs; Mice, Nude; Microscopy, Fluorescence; neoplasms; non-coding RNA; Nuclear Proteins - antagonists & inhibitors; Nuclear Proteins - genetics; Nuclear Proteins - metabolism; oncogenes; precipitin tests; Promoter Regions, Genetic - genetics; Protein Binding; Proteins; Reverse Transcriptase Polymerase Chain Reaction; Ribonucleic acid; RNA; RNA Interference; RNA, Long Noncoding - genetics; RNA, Long Noncoding - metabolism; Transcription Factors - antagonists & inhibitors; Transcription Factors - genetics; Transcription Factors - metabolism; Xenograft Model Antitumor Assays - methods; I-BET151; glioblastoma; long noncoding RNAs; epigenetics; BRD4