Anesthesia and the Quantitative Evaluation of Neurovascular Coupling

Anesthesia has broad actions that include changing neuronal excitability, vascular reactivity, and other baseline physiologies and eventually modifies the neurovascular coupling relationship. Here, we review the effects of anesthesia on the spatial propagation, temporal dynamics, and quantitative re...

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Bibliographic Details
Published inJournal of cerebral blood flow and metabolism Vol. 32; no. 7; pp. 1233 - 1247
Main Authors Masamoto, Kazuto, Kanno, Iwao
Format Journal Article
LanguageEnglish
Published London, England SAGE Publications 01.07.2012
Nature Publishing Group
Sage Publications Ltd
Subjects
Anesthesia
Anesthesia - adverse effects
Anesthetics
Anesthetics - pharmacology
Animals
Attention
Biological and medical sciences
Blood-Brain Barrier - drug effects
Blood-Brain Barrier - physiology
Brain - drug effects
Brain - physiology
Cerebral blood flow
Cerebrovascular Circulation - drug effects
Cerebrovascular Circulation - physiology
Decision making
Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases
Excitability
Hemodynamics - drug effects
Hemodynamics - physiology
Humans
Information processing
Medical sciences
Neuroimaging
Neurology
Neurotransmission
Review
Reviews
Vascular diseases and vascular malformations of the nervous system
Vasoactive agents
Vasodilation
animal models
awake experiments
neuroimaging
Animal model
Nervous system diseases
Central nervous system disease
Cerebrovascular disease
Cerebral disorder
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Abstract Anesthesia has broad actions that include changing neuronal excitability, vascular reactivity, and other baseline physiologies and eventually modifies the neurovascular coupling relationship. Here, we review the effects of anesthesia on the spatial propagation, temporal dynamics, and quantitative relationship between the neural and vascular responses to cortical stimulation. Previous studies have shown that the onset latency of evoked cerebral blood flow (CBF) changes is relatively consistent across anesthesia conditions compared with variations in the time-to-peak. This finding indicates that the mechanism of vasodilation onset is less dependent on anesthesia interference, while vasodilation dynamics are subject to this interference. The quantitative coupling relationship is largely influenced by the type and dosage of anesthesia, including the actions on neural processing, vasoactive signal transmission, and vascular reactivity. The effects of anesthesia on the spatial gap between the neural and vascular response regions are not fully understood and require further attention to elucidate the mechanism of vascular control of CBF supply to the underlying focal and surrounding neural activity. The in-depth understanding of the anesthesia actions on neurovascular elements allows for better decision-making regarding the anesthetics used in specific models for neurovascular experiments and may also help elucidate the signal source issues in hemodynamic-based neuroimaging techniques.
AbstractList Anesthesia has broad actions that include changing neuronal excitability, vascular reactivity, and other baseline physiologies and eventually modifies the neurovascular coupling relationship. Here, we review the effects of anesthesia on the spatial propagation, temporal dynamics, and quantitative relationship between the neural and vascular responses to cortical stimulation. Previous studies have shown that the onset latency of evoked cerebral blood flow (CBF) changes is relatively consistent across anesthesia conditions compared with variations in the time-to-peak. This finding indicates that the mechanism of vasodilation onset is less dependent on anesthesia interference, while vasodilation dynamics are subject to this interference. The quantitative coupling relationship is largely influenced by the type and dosage of anesthesia, including the actions on neural processing, vasoactive signal transmission, and vascular reactivity. The effects of anesthesia on the spatial gap between the neural and vascular response regions are not fully understood and require further attention to elucidate the mechanism of vascular control of CBF supply to the underlying focal and surrounding neural activity. The in-depth understanding of the anesthesia actions on neurovascular elements allows for better decision-making regarding the anesthetics used in specific models for neurovascular experiments and may also help elucidate the signal source issues in hemodynamic-based neuroimaging techniques.
Anesthesia has broad actions that include changing neuronal excitability, vascular reactivity, and other baseline physiologies and eventually modifies the neurovascular coupling relationship. Here, we review the effects of anesthesia on the spatial propagation, temporal dynamics, and quantitative relationship between the neural and vascular responses to cortical stimulation. Previous studies have shown that the onset latency of evoked cerebral blood flow (CBF) changes is relatively consistent across anesthesia conditions compared with variations in the time-to-peak. This finding indicates that the mechanism of vasodilation onset is less dependent on anesthesia interference, while vasodilation dynamics are subject to this interference. The quantitative coupling relationship is largely influenced by the type and dosage of anesthesia, including the actions on neural processing, vasoactive signal transmission, and vascular reactivity. The effects of anesthesia on the spatial gap between the neural and vascular response regions are not fully understood and require further attention to elucidate the mechanism of vascular control of CBF supply to the underlying focal and surrounding neural activity. The in-depth understanding of the anesthesia actions on neurovascular elements allows for better decision-making regarding the anesthetics used in specific models for neurovascular experiments and may also help elucidate the signal source issues in hemodynamic-based neuroimaging techniques.Anesthesia has broad actions that include changing neuronal excitability, vascular reactivity, and other baseline physiologies and eventually modifies the neurovascular coupling relationship. Here, we review the effects of anesthesia on the spatial propagation, temporal dynamics, and quantitative relationship between the neural and vascular responses to cortical stimulation. Previous studies have shown that the onset latency of evoked cerebral blood flow (CBF) changes is relatively consistent across anesthesia conditions compared with variations in the time-to-peak. This finding indicates that the mechanism of vasodilation onset is less dependent on anesthesia interference, while vasodilation dynamics are subject to this interference. The quantitative coupling relationship is largely influenced by the type and dosage of anesthesia, including the actions on neural processing, vasoactive signal transmission, and vascular reactivity. The effects of anesthesia on the spatial gap between the neural and vascular response regions are not fully understood and require further attention to elucidate the mechanism of vascular control of CBF supply to the underlying focal and surrounding neural activity. The in-depth understanding of the anesthesia actions on neurovascular elements allows for better decision-making regarding the anesthetics used in specific models for neurovascular experiments and may also help elucidate the signal source issues in hemodynamic-based neuroimaging techniques.
Author Kanno, Iwao
Masamoto, Kazuto
Author_xml – sequence: 1
  givenname: Kazuto
  surname: Masamoto
  fullname: Masamoto, Kazuto
  email: masamoto@mce.uec.ac.jp
– sequence: 2
  givenname: Iwao
  surname: Kanno
  fullname: Kanno, Iwao
BackLink http://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=26144262$$DView record in Pascal Francis
https://www.ncbi.nlm.nih.gov/pubmed/22510601$$D View this record in MEDLINE/PubMed
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awake experiments
neuroimaging
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Snippet Anesthesia has broad actions that include changing neuronal excitability, vascular reactivity, and other baseline physiologies and eventually modifies the...
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SubjectTerms Anesthesia
Anesthesia - adverse effects
Anesthetics
Anesthetics - pharmacology
Animals
Attention
Biological and medical sciences
Blood-Brain Barrier - drug effects
Blood-Brain Barrier - physiology
Brain - drug effects
Brain - physiology
Cerebral blood flow
Cerebrovascular Circulation - drug effects
Cerebrovascular Circulation - physiology
Decision making
Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases
Excitability
Hemodynamics - drug effects
Hemodynamics - physiology
Humans
Information processing
Medical sciences
Neuroimaging
Neurology
Neurotransmission
Review
Reviews
Vascular diseases and vascular malformations of the nervous system
Vasoactive agents
Vasodilation
Title Anesthesia and the Quantitative Evaluation of Neurovascular Coupling
URI https://journals.sagepub.com/doi/full/10.1038/jcbfm.2012.50
https://www.ncbi.nlm.nih.gov/pubmed/22510601
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https://www.proquest.com/docview/1024098352
https://www.proquest.com/docview/1024665984
https://pubmed.ncbi.nlm.nih.gov/PMC3390804
Volume 32
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