HIV-1 Accessory Protein Vpu Internalizes Cell-surface BST-2/Tetherin through Transmembrane Interactions Leading to Lysosomes

• Published in: The Journal of biological chemistry Vol. 284; no. 50; pp. 35060 - 35072
• Main Authors: Iwabu, Yukie, Fujita, Hideaki, Kinomoto, Masanobu, Kaneko, Keiko, Ishizaka, Yukihito, Tanaka, Yoshitaka, Sata, Tetsutaro, Tokunaga, Kenzo
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 11.12.2009; American Society for Biochemistry and Molecular Biology
• Subjects: Animals; Antigens, CD - genetics; Antigens, CD - metabolism; beta-Transducin Repeat-Containing Proteins - genetics; beta-Transducin Repeat-Containing Proteins - metabolism; CD4 Antigens - metabolism; Cell Line; Cell Membrane - metabolism; Endocytosis - physiology; GPI-Linked Proteins; HIV-1 - genetics; HIV-1 - metabolism; Human immunodeficiency virus 1; Human Immunodeficiency Virus Proteins - genetics; Human Immunodeficiency Virus Proteins - metabolism; Humans; Lysosomes - metabolism; Membrane Glycoproteins - genetics; Membrane Glycoproteins - metabolism; Membrane Transport, Structure, Function, and Biogenesis; Viral Regulatory and Accessory Proteins - genetics; Viral Regulatory and Accessory Proteins - metabolism; Virion - metabolism; Virus Internalization

Bone marrow stromal antigen 2 (BST-2, also known as tetherin) is a recently identified interferon-inducible host restriction factor that can block the production of enveloped viruses by trapping virus particles at the cell surface. This antiviral effect is counteracted by the human immunodeficiency...