Meta-omics uncover temporal regulation of pathways across oral microbiome genera during in vitro sugar metabolism

• Published in: The ISME Journal Vol. 9; no. 12; pp. 2605 - 2619
• Main Authors: Edlund, Anna, Yang, Youngik, Yooseph, Shibu, Hall, Adam P, Nguyen, Don D, Dorrestein, Pieter C, Nelson, Karen E, He, Xuesong, Lux, Renate, Shi, Wenyuan, McLean, Jeffrey S
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.12.2015; Oxford University Press; Nature Publishing Group
• Subjects: 38/39; 45/90; 45/91; 631/326/2565/2134; 82/58; Adult; Bacteria - chemistry; Bacteria - classification; Bacteria - genetics; Bacteria - metabolism; Biomedical and Life Sciences; Carbohydrate Metabolism; Dental Caries - microbiology; Dental Plaque - microbiology; Ecology; Evolutionary Biology; Female; Fermentation; Humans; Hydrogen-Ion Concentration; Infectious diseases; Lactobacillus; Life Sciences; Male; Metabolites; Microbial Ecology; Microbial Genetics and Genomics; Microbiology; Microbiota; Mouth - chemistry; Mouth - microbiology; Original; original-article; Streptococcus; Veillonella

Dental caries, one of the most globally widespread infectious diseases, is intimately linked to pH dynamics. In supragingival plaque, after the addition of a carbohydrate source, bacterial metabolism decreases the pH which then subsequently recovers. Molecular mechanisms supporting this important ho...