Exhaled nitric oxide levels and blood eosinophil counts independently associate with wheeze and asthma events in National Health and Nutrition Examination Survey subjects

• Published in: Journal of allergy and clinical immunology Vol. 132; no. 4; pp. 821 - 827.e5
• Main Authors: Malinovschi, Andrei, Fonseca, João A., Jacinto, Tiago, Alving, Kjell, Janson, Christer
• Format: Journal Article
• Language: English
• Published: New York, NY Mosby, Inc 01.10.2013; Elsevier; Elsevier Limited
• Subjects: Adolescent; Adult; Age; Aged; Aged, 80 and over; Airway management; Allergy and Immunology; Asthma; Asthma - blood; Asthma - diagnosis; Asthma - immunology; Biological and medical sciences; Biomarkers - analysis; Biomarkers - blood; Blood; blood eosinophils; Body mass index; Child; Chronic obstructive pulmonary disease, asthma; Cross-Sectional Studies; Eosinophilia - diagnosis; Eosinophils - physiology; Exhalation; exhaled nitric oxide; Female; Fundamental and applied biological sciences. Psychology; Fundamental immunology; Hay fever; Humans; Immunopathology; inflammation; Laboratories; Leukocyte Count; Logistics; Male; Medical sciences; Middle Aged; National Health and Nutrition Examination Survey; nitric oxide; Nitric Oxide - analysis; Nutrition; Nutrition Surveys; odds ratio; patients; phenotype; Pneumology; questionnaires; Regression analysis; Respiratory Sounds - diagnosis; Respiratory Sounds - physiopathology; Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis; Smoking; Studies; Values; wheeze; Young Adult; ATS; Feno; NO; wheeze; B-Eos; blood eosinophils; Asthma; ECP; inflammation; exhaled nitric oxide; ICS; NHANES; National Health and Nutrition Examination Survey; OCS; BMI; F eno; Fraction of exhaled nitric oxide; Inhaled corticosteroid; Oral corticosteroid; American Thoracic Society; Blood eosinophil count; Body mass index; Nitric oxide; Eosinophil cationic protein; Human; Lung disease; Immunopathology; Respiratory disease; Nutrition survey; Health; Granulocyte; Expiration; Wheezing; Inflammation; Eosinophil; Blood; Immunology; Bronchus disease; Obstructive pulmonary disease; Respiration; Blood cell count

Fraction of exhaled nitric oxide (Feno) and blood eosinophil count (B-Eos) values, markers of local and systemic eosinophilic inflammation, respectively, are increased in asthmatic patients. Little is known about the relation of these markers to reported wheeze and asthma events in a random populati...