Persistent Kruppel-like factor 4 expression predicts progression and poor prognosis of head and neck squamous cell carcinoma

• Published in: Cancer science Vol. 102; no. 4; pp. 895 - 902
• Main Authors: Tai, Shyh‐Kuan, Yang, Muh‐Hwa, Chang, Shyue‐Yih, Chang, Yung‐Chi, Li, Wing‐Yin, Tsai, Tung‐Lung, Wang, Yi‐Fen, Chu, Pen‐Yuan, Hsieh, Shie‐Liang
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Publishing Ltd 01.04.2011; Blackwell
• Subjects: Animals; Antineoplastic Combined Chemotherapy Protocols - pharmacology; Biological and medical sciences; Blotting, Western; Carcinoma, Squamous Cell - drug therapy; Carcinoma, Squamous Cell - metabolism; Carcinoma, Squamous Cell - secondary; Cell Adhesion - drug effects; Cell Movement - drug effects; Cell Proliferation - drug effects; Cisplatin - administration & dosage; Disease Progression; Docetaxel; Drug Resistance, Neoplasm - genetics; Female; Fluorouracil - administration & dosage; Head and Neck Neoplasms - drug therapy; Head and Neck Neoplasms - metabolism; Head and Neck Neoplasms - pathology; Humans; Immunoenzyme Techniques; Kruppel-Like Factor 4; Kruppel-Like Transcription Factors - genetics; Kruppel-Like Transcription Factors - metabolism; Male; Medical sciences; Mice; Mice, Nude; Middle Aged; Neoplasm Invasiveness; Neoplasm Recurrence, Local - drug therapy; Neoplasm Recurrence, Local - metabolism; Neoplasm Recurrence, Local - pathology; Neoplasm Staging; Original; Otorhinolaryngology (head neck, general aspects and miscellaneous); Otorhinolaryngology. Stomatology; Prognosis; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger - genetics; Survival Rate; Taxoids - administration & dosage; Tumor Cells, Cultured; Tumors; Xenograft Model Antitumor Assays; Cancerology; Prognosis; ENT disease; Head and neck cancer; Head and neck squamous cell carcinoma; Malignant tumor; Predictive factor; Krppel-like factor 4; Cancer

Head and neck squamous cell carcinoma (HNSCC) is one prevalent human cancer worldwide. No molecular markers are presently used for predicting prognosis in HNSCC. Krüppel‐like factor 4 (KLF4) is a transcription factor with diverse physiological functions, and possesses opposing roles in different hum...