Mitochondrial Damage‐Induced Innate Immune Activation in Vascular Smooth Muscle Cells Promotes Chronic Kidney Disease‐Associated Plaque Vulnerability

• Published in: Advanced science Vol. 8; no. 5; pp. 2002738 - n/a
• Main Authors: Bi, Xianjin, Du, Changhong, Wang, Xinmiao, Wang, Xue‐Yue, Han, Wenhao, Wang, Yue, Qiao, Yu, Zhu, Yingguo, Ran, Li, Liu, Yong, Xiong, Jiachuan, Huang, Yinghui, Liu, Mingying, Liu, Chi, Zeng, Chunyu, Wang, Junping, Yang, Ke, Zhao, Jinghong
• Format: Journal Article
• Language: English
• Published: Germany John Wiley & Sons, Inc 01.03.2021; John Wiley and Sons Inc; Wiley
• Subjects: Apoptosis; atherosclerosis; chronic kidney disease; cyclic GMP‐AMP synthase‐stimulator of interferon genes pathway; Heart attacks; Hemorrhage; Inflammation; Investigations; Kidney diseases; Pathogenesis; plaque vulnerability; Senescence; Smooth muscle; Student's t-test; Survival analysis; vascular smooth muscle cell; atherosclerosis; chronic kidney disease; vascular smooth muscle cell; plaque vulnerability; cyclic GMP‐AMP synthase‐stimulator of interferon genes pathway

Chronic kidney disease (CKD) is associated with accelerated atherosclerosis progression and high incidence of cardiovascular events, hinting that atherosclerotic plaques in CKD may be vulnerable. However, its cause and mechanism remain obscure. Here, it is shown that apolipoprotein E‐deficient (ApoE...