Seed-competent high-molecular-weight tau species accumulates in the cerebrospinal fluid of Alzheimer's disease mouse model and human patients

• Published in: Annals of neurology Vol. 80; no. 3; pp. 355 - 367
• Main Authors: Takeda, Shuko, Commins, Caitlin, DeVos, Sarah L., Nobuhara, Chloe K., Wegmann, Susanne, Roe, Allyson D., Costantino, Isabel, Fan, Zhanyun, Nicholls, Samantha B., Sherman, Alexis E., Trisini Lipsanopoulos, Ana T., Scherzer, Clemens R., Carlson, George A., Pitstick, Rose, Peskind, Elaine R., Raskind, Murray A., Li, Ge, Montine, Thomas J., Frosch, Matthew P., Hyman, Bradley T.
• Format: Journal Article
• Language: English
• Published: United States Blackwell Publishing Ltd 01.09.2016; Wiley Subscription Services, Inc
• Subjects: Aged; Aggregates; Alzheimer Disease - cerebrospinal fluid; Alzheimer's disease; Animals; Biomarkers; Biomarkers - cerebrospinal fluid; Brain; Brain - metabolism; Cerebrospinal fluid; Extracellular Fluid - metabolism; Female; Health risk assessment; Humans; Male; Mice; Mice, Transgenic; Middle Aged; Molecular weight; Neurodegeneration; Neurodegenerative diseases; Rare species; Rodents; Tau protein; tau Proteins - cerebrospinal fluid; Transgenic mice; Ventricle

Objective Cerebrospinal fluid (CSF) tau is an excellent surrogate marker for assessing neuropathological changes that occur in Alzheimer's disease (AD) patients. However, whether the elevated tau in AD CSF is just a marker of neurodegeneration or, in fact, a part of the disease process is uncer...