high affinity iron permease is a key virulence factor required for Rhizopus oryzae pathogenesis

• Published in: Molecular microbiology Vol. 77; no. 3; pp. 587 - 604
• Main Authors: Ibrahim, Ashraf S, Gebremariam, Teclegiorgis, Lin, Lin, Luo, Guanpingsheng, Husseiny, Mohamed I, Skory, Christopher D, Fu, Yue, French, Samuel W, Edwards, John E. Jr, Spellberg, Brad
• Format: Journal Article
• Language: English
• Published: Oxford, UK Oxford, UK : Blackwell Publishing Ltd 01.08.2010; Blackwell Publishing Ltd; Blackwell
• Subjects: animal disease models; Animals; Biological and medical sciences; diabetic ketoacidosis; Diabetic Ketoacidosis - microbiology; Fundamental and applied biological sciences. Psychology; Fungal infections; Fungal plant pathogens; fungal proteins; Fungal Proteins - genetics; Fungal Proteins - metabolism; Fungi; Gene expression; human diseases; human health; Humans; Iron; Iron - metabolism; iron permease; Male; Membrane Transport Proteins - genetics; Membrane Transport Proteins - metabolism; Mice; Mice, Inbred BALB C; Microbiology; Miscellaneous; Mucormycosis - microbiology; Mycology; mycoses; Pathogenesis; pathogenicity; Phytopathology. Animal pests. Plant and forest protection; Protein Binding; Rhizopus - enzymology; Rhizopus - genetics; Rhizopus - pathogenicity; Rhizopus oryzae; Rodents; transport proteins; Virulence Factors - genetics; Virulence Factors - metabolism; Fungi; Zygomycota; Rhizopus oryzae; Plant pathogen; Pathogenesis; Permease; Virulence; Iron

Rhizopus oryzae is the most common cause of mucormycosis, an angioinvasive fungal infection that causes more then 50% mortality rate despite first-line therapy. Clinical and animal model data clearly demonstrate that the presence of elevated available serum iron predisposes the host to mucormycosis....