9-OR: ADA Presidents' Select Abstract: m6A mRNA Methylation Regulates the Innate Immune Response in Human Beta Cells

• Published in: Diabetes (New York, N.Y.) Vol. 71; no. Supplement_1
• Main Authors: DE JESUS, DARIO F., ZHANG, ZIJIE, BROWN, NATALIE K., BASILE, GIORGIO, XIAO, LING, KAHRAMAN, SEVIM, MATHEWS, CLAYTON E., POWERS, ALVIN C., ATKINSON, MARK A., EIZIRIK, DECIO L., KULKARNI, ROHIT
• Format: Journal Article
• Language: English
• Published: New York American Diabetes Association 01.06.2022
• Subjects: Apoptosis; Autoimmunity; Beta cells; Blood glucose; Cell survival; Cytokines; Diabetes; Diabetes mellitus (insulin dependent); Gene transfer; Hyperglycemia; Immune response; Immune system; Inflammation; Innate immunity; Insulin; mRNA

Innate immunity is directly associated with Type 1 diabetes (T1D) . Recently, N6-methyladenosine (m6A) has been shown to modulate human β-cell biology and innate immunity. Here, we focused on the contribution of m6A in modulating T1D development. RNA-seq. in β-cells revealed downregulation of the m6...