A synergistic approach to the design, fabrication and evaluation of 3D printed micro and nano featured scaffolds for vascularized bone tissue repair

• Published in: Nanotechnology Vol. 27; no. 6; pp. 64001 - 64015
• Main Authors: Holmes, Benjamin, Bulusu, Kartik, Plesniak, Michael, Zhang, Lijie Grace
• Format: Journal Article
• Language: English
• Published: England IOP Publishing 12.02.2016
• Subjects: 3D printing; Adhesion tests; Biocompatibility; Biomedical materials; Bone and Bones - drug effects; Bone and Bones - physiology; Bone Regeneration - drug effects; Bone Regeneration - physiology; Bones; Cell Adhesion - drug effects; Cell Adhesion - physiology; Cell Differentiation - drug effects; Cell Differentiation - physiology; Cell Proliferation - drug effects; Cell Proliferation - physiology; Cells, Cultured; Differentiation; Durapatite - chemistry; endothelial cells; Human Umbilical Vein Endothelial Cells; Humans; Mesenchymal Stromal Cells - drug effects; Mesenchymal Stromal Cells - physiology; nanomaterials; Nanostructure; Nanostructures - chemistry; Osteogenesis - physiology; perfusable channel; Printing; Scaffolds; stem cells; Three dimensional; Tissue Engineering - methods; Tissue Scaffolds - chemistry; vascularized bone

3D bioprinting has begun to show great promise in advancing the development of functional tissue organ replacements. However, to realize the true potential of 3D bioprinted tissues for clinical use requires the fabrication of an interconnected and effective vascular network. Solving this challenge i...