Circulating Complement-C1q TNF-Related Protein 1 Levels Are Increased in Patients with Type 2 Diabetes and Are Associated with Insulin Sensitivity in Chinese Subjects

• Published in: PloS one Vol. 9; no. 5; p. e94478
• Main Authors: Pan, Xuebo, Lu, Tingting, Wu, Fan, Jin, Leigang, Zhang, Yi, Shi, Lihua, Li, Xiaokun, Lin, Zhuofeng
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 14.05.2014; Public Library of Science (PLoS)
• Subjects: Adiponectin; Adiponectin - blood; Adiponectin - genetics; Adipose tissue; Adult; Asian Continental Ancestry Group; Blood Glucose - metabolism; Body mass; Body Mass Index; Case-Control Studies; Complement component C1q; Diabetes mellitus; Diabetes Mellitus, Type 2 - blood; Diabetes Mellitus, Type 2 - ethnology; Diabetes Mellitus, Type 2 - genetics; Diabetes Mellitus, Type 2 - physiopathology; Enzyme-linked immunosorbent assay; Female; Glucose; Glucose metabolism; Glucose tolerance; Glucose tolerance test; Hemoglobin; Humans; Inflammation; Insulin; Insulin - blood; Insulin Resistance; Insulin secretion; Kinases; Lipid Metabolism; Male; Medicine and Health Sciences; Metabolism; Middle Aged; Patients; Physiological aspects; Proteins - genetics; Proteins - metabolism; Rodents; Secretion; Sensitivity; Serum levels; Tumor necrosis factor; Type 2 diabetes; China

Complement-C1q TNF-related protein 1 (CTRP1), a member of the CTRP superfamily, possesses anti-inflammatory and anti-diabetic effects in mice. However, the clinical relevance of CTRP1 has been seldom explored. The current study aimed to investigate the association of circulating CTRP1 and type 2 dia...