Genetics of systemic lupus erythematosus: immune responses and end organ resistance to damage
•GWA studies that identify candidate genes in human lupus are summarized.•Examples of the identification of candidate genes are provided.•Human and murine genes conferring end organ resistance to damage are discussed. Systemic lupus erythematosus (SLE) is a prototypic systemic autoimmune disorder. C...
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| Published in | Current opinion in immunology Vol. 31; pp. 87 - 96 |
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| Main Authors | , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
England
Elsevier Ltd
01.12.2014
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| Subjects | |
| Online Access | Get full text |
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| Abstract | •GWA studies that identify candidate genes in human lupus are summarized.•Examples of the identification of candidate genes are provided.•Human and murine genes conferring end organ resistance to damage are discussed.
Systemic lupus erythematosus (SLE) is a prototypic systemic autoimmune disorder. Considerable progress has been made to delineate the genetic control of this complex disorder. In this review, selected aspects of human and mouse genetics related to SLE are reviewed with emphasis on genes that contribute to both innate and adaptive immunity and to genes that contribute directly to susceptibility to end organ damage. It is concluded that the interactions among these two major pathways will provide further insight into the pathogenesis of SLE. An interactive model of the two major pathways is proposed without emphasis on the importance of breaking tolerance to autoantigens. |
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| AbstractList | Highlights • GWA studies that identify candidate genes in human lupus are summarized. • Examples of the identification of candidate genes are provided. • Human and murine genes conferring end organ resistance to damage are discussed. Systemic lupus erythematosus (SLE) is a prototypic systemic autoimmune disorder. Considerable progress has been made to delineate the genetic control of this complex disorder. In this review, selected aspects of human and mouse genetics related to SLE are reviewed with emphasis on genes that contribute to both innate and adaptive immunity and to genes that contribute directly to susceptibility to end organ damage. It is concluded that the interactions among these two major pathways will provide further insight into the pathogenesis of SLE. An interactive model of the two major pathways is proposed without emphasis on the importance of breaking tolerance to autoantigens.Systemic lupus erythematosus (SLE) is a prototypic systemic autoimmune disorder. Considerable progress has been made to delineate the genetic control of this complex disorder. In this review, selected aspects of human and mouse genetics related to SLE are reviewed with emphasis on genes that contribute to both innate and adaptive immunity and to genes that contribute directly to susceptibility to end organ damage. It is concluded that the interactions among these two major pathways will provide further insight into the pathogenesis of SLE. An interactive model of the two major pathways is proposed without emphasis on the importance of breaking tolerance to autoantigens. Systemic lupus erythematosus (SLE) is a prototypic systemic autoimmune disorder. Considerable progress has been made to delineate the genetic control of this complex disorder. In this review, selected aspects of human and mouse genetics related to SLE are reviewed with emphasis on genes that contribute to both innate and adaptive immunity and to genes that contribute directly to susceptibility to end organ damage. It is concluded that the interactions among these two major pathways will provide further insight into the pathogenesis of SLE. An interactive model of the two major pathways is proposed without emphasis on the importance of breaking tolerance to autoantigens. •GWA studies that identify candidate genes in human lupus are summarized.•Examples of the identification of candidate genes are provided.•Human and murine genes conferring end organ resistance to damage are discussed. Systemic lupus erythematosus (SLE) is a prototypic systemic autoimmune disorder. Considerable progress has been made to delineate the genetic control of this complex disorder. In this review, selected aspects of human and mouse genetics related to SLE are reviewed with emphasis on genes that contribute to both innate and adaptive immunity and to genes that contribute directly to susceptibility to end organ damage. It is concluded that the interactions among these two major pathways will provide further insight into the pathogenesis of SLE. An interactive model of the two major pathways is proposed without emphasis on the importance of breaking tolerance to autoantigens. |
| Author | Fu, Shu Man Gaskin, Felicia Deng, Yun Tsao, Betty P Dai, Chao Quinlan, Aaron |
| AuthorAffiliation | 1 Division of Rheumatology, Center of Inflammation, Immunity and Regenerative Medicine, Department of Medicine, University of Virginia School of Medicine, Charlottesville, VA 22908, United States 2 Division of Rheumatology, Department of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, United States 4 Department of Psychiatry and Neurobehavioral Sciences, University of Virginia School of Medicine, Charlottesville, VA 22908, United States 3 Department of Public Health Sciences, Center for Public Health Genomics, University of Virginia, Charlottesville, VA 22908, United States |
| AuthorAffiliation_xml | – name: 1 Division of Rheumatology, Center of Inflammation, Immunity and Regenerative Medicine, Department of Medicine, University of Virginia School of Medicine, Charlottesville, VA 22908, United States – name: 3 Department of Public Health Sciences, Center for Public Health Genomics, University of Virginia, Charlottesville, VA 22908, United States – name: 4 Department of Psychiatry and Neurobehavioral Sciences, University of Virginia School of Medicine, Charlottesville, VA 22908, United States – name: 2 Division of Rheumatology, Department of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, United States |
| Author_xml | – sequence: 1 givenname: Chao surname: Dai fullname: Dai, Chao organization: Division of Rheumatology, Center of Inflammation, Immunity and Regenerative Medicine, Department of Medicine, University of Virginia School of Medicine, Charlottesville, VA 22908, United States – sequence: 2 givenname: Yun surname: Deng fullname: Deng, Yun organization: Division of Rheumatology, Department of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, United States – sequence: 3 givenname: Aaron surname: Quinlan fullname: Quinlan, Aaron organization: Department of Public Health Sciences, Center for Public Health Genomics, University of Virginia, Charlottesville, VA 22908, United States – sequence: 4 givenname: Felicia surname: Gaskin fullname: Gaskin, Felicia organization: Department of Psychiatry and Neurobehavioral Sciences, University of Virginia School of Medicine, Charlottesville, VA 22908, United States – sequence: 5 givenname: Betty P surname: Tsao fullname: Tsao, Betty P email: BTsao@mednet.ucla.edu organization: Division of Rheumatology, Department of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, United States – sequence: 6 givenname: Shu Man surname: Fu fullname: Fu, Shu Man email: sf2e@virginia.edu organization: Division of Rheumatology, Center of Inflammation, Immunity and Regenerative Medicine, Department of Medicine, University of Virginia School of Medicine, Charlottesville, VA 22908, United States |
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| Snippet | •GWA studies that identify candidate genes in human lupus are summarized.•Examples of the identification of candidate genes are provided.•Human and murine... Highlights • GWA studies that identify candidate genes in human lupus are summarized. • Examples of the identification of candidate genes are provided. • Human... Systemic lupus erythematosus (SLE) is a prototypic systemic autoimmune disorder. Considerable progress has been made to delineate the genetic control of this... |
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| SubjectTerms | Adaptive Immunity - genetics Allergy and Immunology Animals Humans Immunity, Innate - genetics Lupus Erythematosus, Systemic - genetics Lupus Erythematosus, Systemic - immunology Lupus Erythematosus, Systemic - pathology Mice |
| Title | Genetics of systemic lupus erythematosus: immune responses and end organ resistance to damage |
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