Roles of porphyrins and host iron transport proteins in regulation of growth of Porphyromonas gingivalis W50

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Published inJournal of Bacteriology Vol. 173; no. 22; pp. 7330 - 7339
Main Authors BRAMANTI, T. E, HOLT, S. C
Format Journal Article
LanguageEnglish
Published Washington, DC American Society for Microbiology 01.11.1991
Subjects
Animals
Bacteriology
Biological and medical sciences
Blood Proteins - isolation & purification
Blood Proteins - pharmacology
Catalase - pharmacology
Cattle
Cell Membrane - drug effects
Cell Membrane - physiology
Cytochrome c Group - pharmacology
Escherichia coli - drug effects
Escherichia coli - growth & development
Fundamental and applied biological sciences. Psychology
Growth, nutrition, cell differenciation
Heme - metabolism
Heme - pharmacology
Hemoglobins - isolation & purification
Hemoglobins - pharmacology
Horses
Humans
Iron - pharmacology
Lactoperoxidase - pharmacology
Methemoglobin - pharmacology
Microbiology
Myoglobin - isolation & purification
Myoglobin - pharmacology
Porphyrins - pharmacology
Porphyromonas gingivalis
Porphyromonas gingivalis - drug effects
Porphyromonas gingivalis - growth & development
Porphyromonas gingivalis - pathogenicity
Serum Albumin - isolation & purification
Serum Albumin - pharmacology
Virulence - drug effects
Virulence - physiology
Porphyromonas gingivalis
Binding protein
Microorganism growth
Regulation(control)
Porphyrin
Bacteria
Iron
Carrier protein
Bacteroidaceae
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Abstract Article Usage Stats Services JB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit StumbleUpon Twitter current issue JB About JB Subscribers Authors Reviewers Advertisers Inquiries from the Press Permissions & Commercial Reprints ASM Journals Public Access Policy JB RSS Feeds 1752 N Street N.W. • Washington DC 20036 202.737.3600 • 202.942.9355 fax • journals@asmusa.org Print ISSN: 0021-9193 Online ISSN: 1098-5530 Copyright © 2014 by the American Society for Microbiology.   For an alternate route to JB .asm.org, visit: JB       
AbstractList Porphyromonas gingivalis (Bacteroides gingivalis) requires iron in the form of hemin for growth and virulence in vitro, but the contributions of the porphyrin ring structure, porphyrin-associated iron, host hemin-sequestering molecules, and host iron-withholding proteins to its survival are unknown. Therefore, the effects of various porphyrins, host iron transport proteins, and inorganic iron sources on the growth of P. gingivalis W50 were examined to delineate the various types of iron molecules used for cellular metabolism. Cell envelope-associated hemin and iron stores contributed to the growth of P. gingivalis in hemin-free culture, and depletion of these endogenous reserves required eight serial transfers into hemin-free medium for total suppression of growth. Comparable growth of P. gingivalis was observed with 7.7 mu M equivalents of hemin as hemoglobin (HGB), methemoglobin, myoglobin, hemin-saturated serum albumin, lactoperoxidase, cytochrome c, and catalase.
Porphyromonas gingivalis (Bacteroides gingivalis) requires iron in the form of hemin for growth and virulence in vitro, but the contributions of the porphyrin ring structure, porphyrin-associated iron, host hemin-sequestering molecules, and host iron-withholding proteins to its survival are unknown. Therefore, the effects of various porphyrins, host iron transport proteins, and inorganic iron sources on the growth of P. gingivalis W50 were examined to delineate the various types of iron molecules used for cellular metabolism. Cell envelope-associated hemin and iron stores contributed to the growth of P. gingivalis in hemin-free culture, and depletion of these endogenous reserves required eight serial transfers into hemin-free medium for total suppression of growth. Comparable growth of P. gingivalis was observed with 7.7 microM equivalents of hemin as hemoglobin (HGB), methemoglobin, myoglobin, hemin-saturated serum albumin, lactoperoxidase, cytochrome c, and catalase. Unrestricted growth was recorded in the presence of haptoglobin-HGB and hemopexin-hemin complexes, indicating that these host defense proteins do not sequester HGB and hemin from P. gingivalis. The iron chelator 2,2'-bipyridyl functionally chelated hemin-associated iron, resulting in dose-dependent inhibition of growth in hemin-restricted cultures at 1 to 25 microM 2,2'-bipyridyl concentrations. In the absence of an exogenous iron source, protoporphyrin IX did not support P. gingivalis growth. These findings suggest that the iron atom in the hemin molecule is the critical constituent for growth and that the tetrapyrrole porphyrin ring structure may represent an important vehicle for delivery of iron into the P. gingivalis cell. P. gingivalis does not have a strict requirement for porphyrins, since growth occurred with nonhemin iron sources, including high concentrations (200 muM) of ferric, ferrous, and nitrogenous inorganic iron, and P. gingivalis exhibited unrestricted growth in the presence of host transferrin, lactoferrin, and serum albumin. The diversity of iron substrates utilized by P. gingivalis and the observation that growth was not affected by the bacteriostatic effects of host iron-withholding proteins, which it may encounter in the periodontal pocket, may explain why P. gingivalis is such a formidable pathogen in the periodontal disease process.
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Author T E Bramanti
S C Holt
AuthorAffiliation University of Texas Health Science Center, San Antonio 78284-7894
AuthorAffiliation_xml – name: University of Texas Health Science Center, San Antonio 78284-7894
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  surname: HOLT
  fullname: HOLT, S. C
  organization: Univ. Texas health sci. cent. at San Antonio, San Antonio TX 78284-7894, United States
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Issue 22
Keywords Porphyromonas gingivalis
Binding protein
Microorganism growth
Regulation(control)
Porphyrin
Bacteria
Iron
Carrier protein
Bacteroidaceae
Language English
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Porphyromonas gingivalis (Bacteroides gingivalis) requires iron in the form of hemin for growth and virulence in vitro, but the contributions of the porphyrin...
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SubjectTerms Animals
Bacteriology
Biological and medical sciences
Blood Proteins - isolation & purification
Blood Proteins - pharmacology
Catalase - pharmacology
Cattle
Cell Membrane - drug effects
Cell Membrane - physiology
Cytochrome c Group - pharmacology
Escherichia coli - drug effects
Escherichia coli - growth & development
Fundamental and applied biological sciences. Psychology
Growth, nutrition, cell differenciation
Heme - metabolism
Heme - pharmacology
Hemoglobins - isolation & purification
Hemoglobins - pharmacology
Horses
Humans
Iron - pharmacology
Lactoperoxidase - pharmacology
Methemoglobin - pharmacology
Microbiology
Myoglobin - isolation & purification
Myoglobin - pharmacology
Porphyrins - pharmacology
Porphyromonas gingivalis
Porphyromonas gingivalis - drug effects
Porphyromonas gingivalis - growth & development
Porphyromonas gingivalis - pathogenicity
Serum Albumin - isolation & purification
Serum Albumin - pharmacology
Virulence - drug effects
Virulence - physiology
Title Roles of porphyrins and host iron transport proteins in regulation of growth of Porphyromonas gingivalis W50
URI http://jb.asm.org/content/173/22/7330.abstract
https://www.ncbi.nlm.nih.gov/pubmed/1657888
https://search.proquest.com/docview/16361247
https://search.proquest.com/docview/72455571
https://pubmed.ncbi.nlm.nih.gov/PMC209241
Volume 173
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