A case-control study of occupation/industry and renal cell carcinoma risk

• Published in: BMC cancer Vol. 12; no. 1; p. 344
• Main Authors: Karami, Sara, Colt, Joanne S, Schwartz, Kendra, Davis, Faith G, Ruterbusch, Julie J, Munuo, Stella S, Wacholder, Sholom, Stewart, Patricia A, Graubard, Barry I, Rothman, Nathanial, Chow, Wong-Ho, Purdue, Mark P
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 08.08.2012; BioMed Central; BMC
• Subjects: Adult; African Americans; Aged; Automobile services industry; Cancer; Carcinoma, Renal cell; Carcinoma, Renal Cell - epidemiology; Case-Control Studies; Chicago - epidemiology; Clear cell RCC; Development and progression; Epidemiologic Research Design; Epidemiology; Female; Health aspects; Humans; Industry; Industry - statistics & numerical data; Kidney cancer; Kidney Neoplasms - epidemiology; Logistic Models; Maintenance and repair; Male; Michigan - epidemiology; Middle Aged; Motor vehicles; Occupation; Occupational Diseases - epidemiology; Occupations - statistics & numerical data; Odds Ratio; Oncology, Experimental; Race; Renal cancer; Risk Factors; Studies; Chicago; Michigan; United States; Detroit Michigan; United States > US; Chicago Illinois
• DOI: 10.1186/1471-2407-12-344
• ISSN: 1471-2407

The role of occupation in the etiology of renal cell carcinoma (RCC) is unclear. Here, we investigated associations between employment in specific occupations and industries and RCC, and its most common histologic subtype, clear cell RCC (ccRCC). Between 2002 and 2007, a population-based case-control study of Caucasians and African Americans (1,217 cases; 1,235 controls) was conducted within the Detroit and Chicago metropolitan areas to investigate risk factors for RCC. As part of this study, occupational histories were ascertained through in-person interviews. We computed odds ratios (ORs) and 95% confidence intervals (CIs) relating occupation and industry to RCC risk using adjusted unconditional logistic regression models. Employment in the agricultural crop production industry for five years or more was associated with RCC (OR = 3.3 [95% CI = 1.0-11.5]) and ccRCC in particular (OR = 6.3 [95% CI = 1.7-23.3], P for trend with duration of employment = 0.0050). Similarly, RCC risk was elevated for employment of five years or longer in non-managerial agricultural and related occupations (ORRCC = 2.1 [95% CI = 1.0-4.5]; ORccRCC = 3.1 [95% CI = 1.4-6.8]). Employment in the dry-cleaning industry was also associated with elevated risk (ORRCC = 2.0 [95% CI = 0.9-4.4], P for trend = 0.093; ORccRCC = 3.0 [95% CI = 1.2-7.4], P for trend = 0.031). Suggestive elevated associations were observed for police/public safety workers, health care workers and technicians, and employment in the electronics, auto repair, and cleaning/janitorial services industries; protective associations were suggested for many white-collar jobs including computer science and administrative occupations as well employment in the business, legislative, and education industries. Our findings provide support for an elevated risk of RCC in the agricultural and dry-cleaning industries and suggest that these associations may be stronger for the ccRCC subtype. Additional studies are needed to confirm these findings.