Macrophage migration inhibitory factor stimulates AMP-activated protein kinase in the ischaemic heart

• Published in: Nature Vol. 451; no. 7178; pp. 578 - 582
• Main Authors: Miller, Edward J., Li, Ji, Leng, Lin, McDonald, Courtney, Atsumi, Toshiya, Bucala, Richard, Young, Lawrence H.
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 31.01.2008; Nature Publishing Group
• Subjects: AMP-Activated Protein Kinases; Animals; Antigens, Differentiation, B-Lymphocyte - genetics; Antigens, Differentiation, B-Lymphocyte - metabolism; Apoptosis; Cardiovascular disease; Cell adhesion & migration; Cell migration; Cellular biology; Control; Coronary Artery Disease - genetics; Cyclic adenylic acid; Cytokines; Environmental stress; Enzyme Activation; Genetic diversity; Genetic Predisposition to Disease; Genotype; Glucose - metabolism; Health aspects; Histocompatibility Antigens Class II - genetics; Histocompatibility Antigens Class II - metabolism; Hormones; Humanities and Social Sciences; Humans; Hypoxia; Hypoxia - enzymology; Hypoxia - genetics; Hypoxia - metabolism; Kinases; letter; Macrophage Migration-Inhibitory Factors - deficiency; Macrophage Migration-Inhibitory Factors - genetics; Macrophage Migration-Inhibitory Factors - metabolism; Macrophage Migration-Inhibitory Factors - secretion; Macrophages; Mice; multidisciplinary; Multienzyme Complexes - metabolism; Myocardial ischemia; Myocardial Ischemia - enzymology; Myocardial Ischemia - genetics; Myocardial Ischemia - metabolism; Myocardial Reperfusion Injury - physiopathology; Myocardial Reperfusion Injury - prevention & control; Myocardium - enzymology; Myocardium - metabolism; Polymorphism, Genetic - genetics; Promoter Regions, Genetic - genetics; Protein kinases; Protein-Serine-Threonine Kinases - metabolism; Rats; Risk factors; Science; Science (multidisciplinary); Signal Transduction; Stress; United States

The heart under stress AMPK (AMP-activated protein kinase) is a master regulator of many biological processes and is a potential drug target for diseases as diverse as diabetes, cancer, atherosclerosis and ischaemic heart disease. In the ischaemic heart, AMPK protects tissues from injury and apoptos...