JAK inhibitor has the amelioration effect in lupus-prone mice: the involvement of IFN signature gene downregulation

We previously reported that JAK-STAT-pathway mediated regulation of IFN-regulatory factor genes could play an important role in SLE pathogenesis. Here, we evaluated the efficacy of the JAK inhibitor tofacitinib (TOFA) for controlling IFN signalling via the JAK-STAT pathway and as a therapeutic for S...

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Published inBMC immunology Vol. 18; no. 1; p. 41
Main Authors Ikeda, Keigo, Hayakawa, Kunihiro, Fujishiro, Maki, Kawasaki, Mikiko, Hirai, Takuya, Tsushima, Hiroshi, Miyashita, Tomoko, Suzuki, Satoshi, Morimoto, Shinji, Tamura, Naoto, Takamori, Kenji, Ogawa, Hideoki, Sekigawa, Iwao
Format Journal Article
LanguageEnglish
Published England BioMed Central Ltd 22.08.2017
BioMed Central
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