Origin and diversity of novel avian influenza A H7N9 viruses causing human infection: phylogenetic, structural, and coalescent analyses

• Published in: The Lancet (British edition) Vol. 381; no. 9881; pp. 1926 - 1932
• Main Authors: Liu, Di, Shi, Weifeng, Shi, Yi, Wang, Dayan, Xiao, Haixia, Li, Wei, Bi, Yuhai, Wu, Ying, Li, Xianbin, Yan, Jinghua, Liu, Wenjun, Zhao, Guoping, Yang, Weizhong, Wang, Yu, Ma, Juncai, Shu, Yuelong, Lei, Fumin, Gao, George F
• Format: Journal Article
• Language: English
• Published: Kidlington Elsevier Ltd 01.06.2013; Elsevier; Elsevier Limited
• Subjects: Animals; Aquatic birds; avian influenza; binding properties; Biological and medical sciences; Biological Evolution; Bird migration; Chickens; China; cities; Ducks; Family planning; General aspects; genes; Genome, Viral - genetics; human diseases; Human viral diseases; humans; Infectious diseases; Influenza; Influenza A virus - genetics; Influenza in Birds - virology; Influenza virus; intermediate hosts; Internal Medicine; Markov chain; Markov Chains; Medical sciences; migratory behavior; Migratory birds; monitoring; Monte Carlo method; Monte Carlo simulation; mutation; nucleotide sequences; Orthomyxoviridae; Phenotype; Phylogeny; Poultry; sequence alignment; Sequence Alignment - methods; Sequence Homology; Topology; Trees; Viral diseases; Viral diseases of the respiratory system and ent viral diseases; virulence; viruses; China; Beijing China; China, People's Rep; Infection; Avian influenza; Human; Medicine; Viral disease; Phylogenetic tree; Diversity; Influenza A; Structural analysis

On March 30, 2013, a novel avian influenza A H7N9 virus that infects human beings was identified. This virus had been detected in six provinces and municipal cities in China as of April 18, 2013. We correlated genomic sequences from avian influenza viruses with ecological information and did phyloge...