Mitoflash frequency in early adulthood predicts lifespan in Caenorhabditis elegans

• Published in: Nature (London) Vol. 508; no. 7494; pp. 128 - 132
• Main Authors: Shen, En-Zhi, Song, Chun-Qing, Lin, Yuan, Zhang, Wen-Hong, Su, Pei-Fang, Liu, Wen-Yuan, Zhang, Pan, Xu, Jiejia, Lin, Na, Zhan, Cheng, Wang, Xianhua, Shyr, Yu, Cheng, Heping, Dong, Meng-Qiu
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 03.04.2014; Nature Publishing Group
• Subjects: 14; 14/19; 14/35; 631/136/7; 631/208/182; 631/443/7; 631/80/642/333/1465; 64/11; 82/58; 9/10; Age; Aging; Aging - metabolism; Analysis; Animals; Animals, Genetically Modified; Biological clocks; Caenorhabditis elegans; Caenorhabditis elegans - cytology; Caenorhabditis elegans - genetics; Caenorhabditis elegans - metabolism; Caenorhabditis elegans - physiology; Caenorhabditis elegans Proteins - genetics; Death; Energy Metabolism; Environment; Environmental aspects; Environmental factors; Forecasts and trends; Genetic aspects; Glyoxylates - metabolism; Hermaphroditic Organisms; Humanities and Social Sciences; Insulin; letter; Life span; Life spans (Biology); Longevity - genetics; Longevity - physiology; Male; Mitochondria; Mitochondria - metabolism; Mitochondrial biogenesis; Models, Biological; multidisciplinary; Muscles; Muscles - cytology; Mutation; Oxidative Stress; Proteins; Receptor, Insulin - genetics; Reproduction; Science; Stochastic Processes; Superoxides - analysis; Superoxides - metabolism; Testing; Time Factors; China

In Caenorhabditis elegans , mitochondrial activity as measured by the frequency of the mitochondrial flash in young adult animals is a powerful predictor of lifespan across genetic, environmental and stochastic factors. Mitoflash activity tests ageing theory The mitochondrial theory of ageing, devel...