TAM receptor tyrosine kinases: Expression, disease and oncogenesis in the central nervous system
Abstract Receptor tyrosine kinases (RTKs) are cell surface proteins that tightly regulate a variety of downstream intra-cellular processes; ligand-receptor interactions result in cascades of signaling events leading to growth, proliferation, differentiation and migration. There are 58 described RTKs...
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| Published in | Brain research Vol. 1542; pp. 206 - 220 |
|---|---|
| Main Authors | , |
| Format | Journal Article |
| Language | English |
| Published |
Amsterdam
Elsevier B.V
13.01.2014
Elsevier |
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| Abstract | Abstract Receptor tyrosine kinases (RTKs) are cell surface proteins that tightly regulate a variety of downstream intra-cellular processes; ligand-receptor interactions result in cascades of signaling events leading to growth, proliferation, differentiation and migration. There are 58 described RTKs, which are further categorized into 20 different RTK families. When dysregulated or overexpressed, these RTKs are implicated in disordered growth, development, and oncogenesis. The TAM family of RTKs, consisting of Tyro3, Axl, and MerTK, is prominently expressed during the development and function of the central nervous system (CNS). Aberrant expression and dysregulated activation of TAM family members has been demonstrated in a variety of CNS-related disorders and diseases, including the most common but least treatable brain cancer in children and adults: glioblastoma multiforme. |
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| AbstractList | Receptor tyrosine kinases (RTKs) are cell surface proteins that tightly regulate a variety of downstream intra-cellular processes; ligand-receptor interactions result in cascades of signaling events leading to growth, proliferation, differentiation and migration. There are 58 described RTKs, which are further categorized into 20 different RTK families. When dysregulated or overexpressed, these RTKs are implicated in disordered growth, development, and oncogenesis. The TAM family of RTKs, consisting of Tyro3, Axl, and MerTK, is prominently expressed during the development and function of the central nervous system (CNS). Aberrant expression and dysregulated activation of TAM family members has been demonstrated in a variety of CNS-related disorders and diseases, including the most common but least treatable brain cancer in children and adults: glioblastoma multiforme. Receptor tyrosine kinases (RTKs) are cell surface proteins that tightly regulate a variety of downstream intra-cellular processes; ligand-receptor interactions result in cascades of signaling events leading to growth, proliferation, differentiation and migration. There are 58 described RTKs, which are further categorized into 20 different RTK families. When dysregulated or overexpressed, these RTKs are implicated in disordered growth, development, and oncogenesis. The TAM family of RTKs, consisting of Tyro3, Axl, and MerTK, is prominently expressed during the development and function of the central nervous system (CNS). Aberrant expression and dysregulated activation of TAM family members has been demonstrated in a variety of CNS-related disorders and diseases, including the most common but least treatable brain cancer in children and adults: glioblastoma multiforme. •TAM receptors in the central nervous system (CNS) play both unique and familiar roles.•Aberrantly expressed TAMs play a causative role in a variety of human CNS pathologies.•TAM receptors are promising targets for intervention and therapy. Abstract Receptor tyrosine kinases (RTKs) are cell surface proteins that tightly regulate a variety of downstream intra-cellular processes; ligand-receptor interactions result in cascades of signaling events leading to growth, proliferation, differentiation and migration. There are 58 described RTKs, which are further categorized into 20 different RTK families. When dysregulated or overexpressed, these RTKs are implicated in disordered growth, development, and oncogenesis. The TAM family of RTKs, consisting of Tyro3, Axl, and MerTK, is prominently expressed during the development and function of the central nervous system (CNS). Aberrant expression and dysregulated activation of TAM family members has been demonstrated in a variety of CNS-related disorders and diseases, including the most common but least treatable brain cancer in children and adults: glioblastoma multiforme. |
| Author | Keating, Amy K Pierce, Angela M |
| Author_xml | – sequence: 1 fullname: Pierce, Angela M – sequence: 2 fullname: Keating, Amy K |
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| Cites_doi | 10.1007/s11481-007-9090-2 10.1016/j.mcn.2006.06.011 10.1002/jcp.22955 10.4049/jimmunol.162.6.3498 10.1016/S0092-8674(88)91065-3 10.1371/journal.pone.0015748 10.1002/glia.20546 10.1074/jbc.M112086200 10.1021/bi400209z 10.1182/blood-2006-05-021634 10.1016/j.immuni.2013.06.010 10.1371/journal.pone.0016964 10.1182/blood.V95.2.633 10.1002/art.37786 10.1523/JNEUROSCI.5063-05.2006 10.1371/journal.pone.0036800 10.1038/onc.2011.588 10.1016/j.brainres.2008.08.076 10.1128/MCB.15.12.6582 10.1128/MCB.16.1.135 10.1186/1750-1326-6-13 10.1182/blood-2010-01-262386 10.1016/S0006-8993(98)01159-7 10.1523/JNEUROSCI.4178-07.2008 10.1038/emboj.2012.21 10.1523/JNEUROSCI.23-10-04208.2003 10.1111/j.1742-4658.2006.05529.x 10.1158/1535-7163.MCT-11-0116 10.1038/sj.onc.1201419 10.1016/j.neuroscience.2007.09.047 10.1073/pnas.0510923103 10.1038/81555 10.1074/jbc.270.2.551 10.1128/MCB.13.8.4976 10.1517/14728222.2010.515980 10.1038/35075603 10.1016/S0065-230X(08)00002-X 10.1126/science.1061663 10.1158/1078-0432.CCR-07-0862 10.1074/jbc.271.47.30022 10.1016/S0021-9258(17)34118-2 10.1038/sj.emboj.7600912 10.1371/journal.pone.0031635 10.1242/jcs.01632 10.1210/me.2008-0169 10.1530/REP-09-0101 10.1038/nri2303 10.1523/JNEUROSCI.16-06-02012.1996 10.1093/hmg/9.4.645 10.1128/MCB.11.10.5016 10.1016/S0092-8674(00)00114-8 10.1128/MCB.15.2.614 10.1016/0896-6273(91)90167-X 10.1167/iovs.02-0438 10.1159/000015223 10.1523/JNEUROSCI.1180-08.2008 10.1016/S0021-9258(17)42103-X 10.1016/j.mce.2011.04.007 10.1002/humu.20025 10.1038/sj.onc.1209633 10.1111/j.1471-4159.2008.05343.x 10.1038/sj.onc.1201039 10.1002/jnr.10211 10.1158/1078-0432.CCR-05-2208 10.2353/ajpath.2009.080807 10.1159/000231894 10.1093/oxfordjournals.jbchem.a124854 10.1038/emboj.2010.265 10.1371/journal.pone.0064812 10.1016/j.neuron.2012.10.015 10.1074/jbc.M311750200 10.1189/jlb.0608334 10.1186/1742-2094-8-49 10.1530/REP-07-0287 10.1210/en.2007-0039 10.1016/j.yexcr.2009.10.008 10.1053/j.gastro.2012.07.097 10.1016/j.cell.2007.10.034 10.1016/0092-8674(95)90520-0 10.1016/j.coi.2010.10.001 10.1128/JVI.66.10.5975-5987.1992 10.1259/bjr/23430927 10.1038/373623a0 10.1210/mend.13.2.0230 10.1073/pnas.85.6.1952 10.1016/0169-328X(94)00216-2 10.1016/j.mce.2013.04.018 10.1371/journal.pone.0039035 10.1158/1535-7163.MCT-09-0707 10.1073/pnas.90.15.7044 10.1074/jbc.270.12.6872 10.1093/brain/aws262 10.1006/geno.1996.0003 10.1002/1096-9861(20000918)425:2<295::AID-CNE11>3.0.CO;2-G 10.1016/S0028-3908(02)00333-7 10.1038/19554 10.1016/S0304-3940(99)00928-3 |
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| Keywords | Multiple sclerosis Developmental neurology Alzheimer's disease Cell signaling Glioblastoma Nervous system diseases Alzheimer disease Central nervous system trk receptor Inflammatory disease Cerebral disorder Signal transduction Central nervous system disease Development Degenerative disease |
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| References | Pierce (bib68) 2008; 22 Lai, Lemke (bib42) 1991; 6 Bellosta (bib4) 1997; 15 Rothlin, Lemke (bib78) 2010; 22 Weier, Fung, Lersch (bib101) 1999; 84 Xiong (bib107) 2008; 135 Weinger (bib103) 2009; 175 Guttridge (bib31) 2002; 277 Heiring, Dahlback, Muller (bib33) 2004; 279 Allen (bib1) 1999; 13 Caberoy, Zhou (bib11) 2010; 29 Lu, Lemke (bib55) 2001; 293 Prieto, Weber, Lai (bib72) 2000; 425 Rescigno, Mansukhani (bib75) 1991; 6 Shankar (bib88) 2006; 26 Grommes (bib29) 2008; 3 Zhu (bib111) 2010; 115 Munoz (bib60) 2004; 23 Funakoshi (bib23) 2002; 68 Graham (bib27) 1995; 10 Nielsen-Preiss (bib62) 2007; 148 Carrera Silva (bib16) 2013; 39 Lewis (bib46) 1996; 31 Manfioletti (bib57) 1993; 13 Hafizi, Dahlback (bib32) 2006; 273 Schneider, King, Philipson (bib84) 1988; 54 Duncan (bib20) 2003; 44 Ohashi (bib66) 1995; 117 Prieto (bib71) 1999; 816 Li (bib47) 2013; 8 Jia, Hanafusa (bib38) 1994; 269 Anwar (bib2) 2009; 86 Pierce (bib69) 2011; 339 Linger (bib52) 2008; 100 Scott (bib86) 2001; 411 Biesecker, Gottschalk, Emerson (bib5) 1993; 90 Guo (bib30) 2011; 6 Zheng (bib109) 2012; 7 Ma (bib56) 2011; 6 Hutterer (bib35) 2008; 14 Hoehn (bib34) 2008; 1240 Varnum (bib97) 1995; 373 Chen, Carey, Godowski (bib17) 1997; 14 Nagata (bib61) 1996; 271 Sather (bib82) 2007; 109 Camenisch (bib14) 1999; 162 Janssen (bib36) 1991; 6 Cahoy (bib13) 2008; 28 Caberoy (bib12) 2012; 227 D’Cruz (bib19) 2000; 9 Migdall-Wilson (bib59) 2012; 7 Ruan, Kazlauskas (bib79) 2012; 31 O’Bryan (bib64) 1995; 270 Taylor (bib93) 1995; 270 Brown (bib8) 2012; 7 Fridell (bib21) 1996; 16 Singh (bib89) 2003; 63 Lu (bib54) 1999; 398 Kilpatrick (bib41) 2000; 279 Ramachandran, Udgaonkar (bib74) 2013; 52 Gal (bib24) 2000; 26 Schlessinger (bib83) 2000; 103 Burstyn-Cohen (bib9) 2012; 76 Wu (bib106) 2005; 118 Lan (bib44) 2000; 95 Ohashi (bib65) 1994; 9 Stitt (bib91) 1995; 80 Walker (bib99) 2011; 84 Yagami (bib108) 2002; 43 Goruppi, Ruaro, Schneider (bib25) 1996; 12 Prieto (bib73) 2007; 150 Weinger (bib102) 2008; 106 Taylor, Roy, Varmus (bib92) 1995; 11 Graham (bib26) 1994; 5 Wang (bib100) 2012 Ling, Kung (bib49) 1995; 15 Binder (bib6) 2008; 28 Verma (bib98) 2011; 10 Li (bib48) 1996; 16 Patin (bib67) 2012; 143 Keating (bib39) 2006; 25 Fujimoto, Yamamoto (bib22) 1994; 9 Jia (bib37) 1992; 66 van den Brand (bib96) 2013; 65 Keating (bib40) 2010; 9 Mark (bib58) 1994; 269 Schulz (bib85) 1995; 28 Binder, Kilpatrick (bib7) 2009; 17 Prasad (bib70) 2006; 33 Bellosta (bib3) 1995; 15 Tsiperson (bib94) 2010; 5 Lemke, Rothlin (bib45) 2008; 8 Zhong (bib110) 2010; 30 Linger (bib51) 2010; 14 Salian-Mehta, Xu, Wierman (bib80) 2013; 374 O’Bryan (bib63) 1991; 11 Graham (bib28) 2006; 12 Lai, Gore, Lemke (bib43) 1994; 9 Williams, Piaton, Lubetzki (bib105) 2007; 55 Rothlin (bib77) 2007; 131 Sasaki (bib81) 2006; 25 Caberoy (bib10) 2009; 316 Weinger (bib104) 2011; 8 Carr (bib15) 2009; 15 Chen (bib18) 2009; 138 Ling, Kung (bib50) 1995; 15 Liu, Hjelle, Bishop (bib53) 1988; 85 Skripuletz (bib90) 2013; 136 Shankar (bib87) 2003; 23 Vajkoczy (bib95) 2006; 103 Rogers (bib76) 2011; 31 7896835 - J Biol Chem. 1995 Mar 24;270(12):6872-80 7784083 - Oncogene. 1995 Jun 15;10(12):2349-59 10343112 - Cytogenet Cell Genet. 1999;84(1-2):91-2 12556419 - Invest Ophthalmol Vis Sci. 2003 Feb;44(2):826-38 17047157 - Blood. 2007 Feb 1;109(3):1026-33 18083102 - Cell. 2007 Dec 14;131(6):1124-36 18171944 - J Neurosci. 2008 Jan 2;28(1):264-78 23203851 - Arthritis Rheum. 2013 Mar;65(3):671-80 8524223 - Mol Cell Biol. 1995 Dec;15(12):6582-92 14522905 - Cancer Res. 2003 Sep 15;63(18):5821-8 20348395 - Blood. 2010 Jun 10;115(23):4963-72 9878891 - Brain Res. 1999 Jan 23;816(2):646-61 2025425 - Neuron. 1991 May;6(5):691-704 12527478 - Neuropharmacology. 2002 Dec;43(8):1289-96 21792939 - J Cell Physiol. 2012 Feb;227(2):401-7 7822279 - J Biol Chem. 1995 Jan 13;270(2):551-7 8058320 - Oncogene. 1994 Sep;9(9):2567-78 8108112 - Oncogene. 1994 Mar;9(3):699-705 10227296 - Nature. 1999 Apr 22;398(6729):723-8 18421305 - Nat Rev Immunol. 2008 May;8(5):327-36 7854420 - Nature. 1995 Feb 16;373(6515):623-6 8637702 - Oncogene. 1996 Feb 1;12(3):471-80 20978472 - EMBO J. 2010 Dec 1;29(23):3898-910 17064312 - FEBS J. 2006 Dec;273(23):5231-44 11346799 - Nature. 2001 May 10;411(6834):207-11 8086340 - Cell Growth Differ. 1994 Jun;5(6):647-57 17980494 - Neuroscience. 2007 Dec 5;150(2):319-34 9395235 - Oncogene. 1997 Nov 13;15(20):2387-97 9973250 - Mol Endocrinol. 1999 Feb;13(2):191-201 18787040 - Mol Endocrinol. 2008 Nov;22(11):2481-95 17332061 - Endocrinology. 2007 Jun;148(6):2806-14 18172262 - Clin Cancer Res. 2008 Jan 1;14(1):130-8 10092806 - J Immunol. 1999 Mar 15;162(6):3498-503 16901715 - Mol Cell Neurosci. 2006 Sep;33(1):96-108 21539887 - Mol Cell Endocrinol. 2011 Jun 6;339(1-2):151-8 19602523 - Reproduction. 2009 Oct;138(4):655-66 12764109 - J Neurosci. 2003 May 15;23(10):4208-18 8939948 - J Biol Chem. 1996 Nov 22;271(47):30022-7 11948660 - J Neurosci Res. 2002 Apr 15;68(2):150-60 21203420 - PLoS One. 2010;5(12):e15748 23850380 - Immunity. 2013 Jul 25;39(1):160-70 21030229 - Curr Opin Immunol. 2010 Dec;22(6):740-6 16362042 - EMBO J. 2006 Jan 11;25(1):80-7 22701746 - PLoS One. 2012;7(6):e39035 19541935 - Am J Pathol. 2009 Jul;175(1):283-93 16723520 - J Neurosci. 2006 May 24;26(21):5638-48 22469987 - Oncogene. 2013 Feb 14;32(7):872-82 18480276 - J Neurosci. 2008 May 14;28(20):5195-206 15673687 - J Cell Sci. 2005 Feb 1;118(Pt 3):539-53 19837063 - Exp Cell Res. 2010 Jan 15;316(2):245-57 8604045 - J Neurosci. 1996 Mar 15;16(6):2012-9 3279421 - Proc Natl Acad Sci U S A. 1988 Mar;85(6):1952-6 7723626 - Brain Res Mol Brain Res. 1995 Feb;28(2):273-80 23840307 - PLoS One. 2013;8(6):e64812 19816064 - Neurosignals. 2009;17(4):277-87 7490270 - J Biochem. 1995 Jun;117(6):1267-75 23648337 - Mol Cell Endocrinol. 2013 Jul 15;374(1-2):92-100 23266461 - Brain. 2013 Jan;136(Pt 1):147-67 21933973 - Mol Cancer Ther. 2011 Oct;10(10):1763-73 22606290 - PLoS One. 2012;7(5):e36800 10954847 - J Comp Neurol. 2000 Sep 18;425(2):295-314 7507487 - J Biol Chem. 1994 Jan 21;269(3):1839-44 19386698 - J Leukoc Biol. 2009 Jul;86(1):73-9 22433833 - Br J Radiol. 2011 Dec;84 Spec No 2:S90-106 21347448 - PLoS One. 2011;6(2):e16964 11062461 - Nat Genet. 2000 Nov;26(3):270-1 23721410 - Biochemistry. 2013 Jun 18;52(24):4107-26 8108111 - Oncogene. 1994 Mar;9(3):693-8 22363695 - PLoS One. 2012;7(2):e31635 15108283 - Hum Mutat. 2004 May;23(5):506-12 22327215 - EMBO J. 2012 Apr 4;31(7):1692-703 11929866 - J Biol Chem. 2002 Jul 5;277(27):24057-66 17626262 - Glia. 2007 Oct;55(13):1300-12 20423999 - Mol Cancer Ther. 2010 May;9(5):1298-307 22841784 - Gastroenterology. 2012 Nov;143(5):1244-52.e1-12 1527848 - J Virol. 1992 Oct;66(10):5975-87 16585512 - Proc Natl Acad Sci U S A. 2006 Apr 11;103(15):5799-804 11057895 - Cell. 2000 Oct 13;103(2):211-25 1834974 - Oncogene. 1991 Nov;6(11):2113-20 1840679 - Oncogene. 1991 Oct;6(10):1909-13 10699188 - Hum Mol Genet. 2000 Mar 1;9(4):645-51 21084607 - J Neurosci. 2010 Nov 17;30(46):15521-34 10627473 - Blood. 2000 Jan 15;95(2):633-8 23259948 - Neuron. 2012 Dec 20;76(6):1123-32 21291561 - Mol Neurodegener. 2011 Feb 03;6:13 22179835 - Oncogene. 2012 Sep 20;31(38):4171-81 18247125 - J Neuroimmune Pharmacol. 2008 Jun;3(2):130-40 14623883 - J Biol Chem. 2004 Feb 20;279(8):6952-8 1656220 - Mol Cell Biol. 1991 Oct;11(10):5016-31 8808274 - Genomics. 1996 Jan 1;31(1):13-9 7823930 - Mol Cell Biol. 1995 Feb;15(2):614-25 8524290 - Mol Cell Biol. 1996 Jan;16(1):135-45 8346215 - Proc Natl Acad Sci U S A. 1993 Aug 1;90(15):7044-8 20809868 - Expert Opin Ther Targets. 2010 Oct;14(10):1073-90 16675557 - Clin Cancer Res. 2006 May 1;12(9):2662-9 18346204 - J Neurochem. 2008 Jul;106(1):134-46 18159085 - Reproduction. 2008 Jan;135(1):77-87 18620092 - Adv Cancer Res. 2008;100:35-83 16652142 - Oncogene. 2006 Oct 5;25(45):6092-100 3409319 - Cell. 1988 Sep 9;54(6):787-93 11452127 - Science. 2001 Jul 13;293(5528):306-11 8545119 - Oncogene. 1995 Dec 21;11(12):2619-26 18804096 - Brain Res. 2008 Nov 13;1240:1-11 21569627 - J Neuroinflammation. 2011;8:49 7867073 - Cell. 1995 Feb 24;80(4):661-70 7511603 - J Biol Chem. 1994 Apr 8;269(14):10720-8 8336730 - Mol Cell Biol. 1993 Aug;13(8):4976-85 19204785 - Mol Vis. 2009;15:283-95 10670774 - Neurosci Lett. 2000 Jan 21;279(1):5-8 9160883 - Oncogene. 1997 May 1;14(17):2033-9 Wang (10.1016/j.brainres.2013.10.049_bib100) 2012 Yagami (10.1016/j.brainres.2013.10.049_bib108) 2002; 43 Caberoy (10.1016/j.brainres.2013.10.049_bib12) 2012; 227 Weinger (10.1016/j.brainres.2013.10.049_bib104) 2011; 8 Nagata (10.1016/j.brainres.2013.10.049_bib61) 1996; 271 Munoz (10.1016/j.brainres.2013.10.049_bib60) 2004; 23 Bellosta (10.1016/j.brainres.2013.10.049_bib3) 1995; 15 Wu (10.1016/j.brainres.2013.10.049_bib106) 2005; 118 Funakoshi (10.1016/j.brainres.2013.10.049_bib23) 2002; 68 Allen (10.1016/j.brainres.2013.10.049_bib1) 1999; 13 Li (10.1016/j.brainres.2013.10.049_bib48) 1996; 16 Sather (10.1016/j.brainres.2013.10.049_bib82) 2007; 109 Hoehn (10.1016/j.brainres.2013.10.049_bib34) 2008; 1240 Lai (10.1016/j.brainres.2013.10.049_bib43) 1994; 9 Rogers (10.1016/j.brainres.2013.10.049_bib76) 2011; 31 Shankar (10.1016/j.brainres.2013.10.049_bib87) 2003; 23 Binder (10.1016/j.brainres.2013.10.049_bib6) 2008; 28 Burstyn-Cohen (10.1016/j.brainres.2013.10.049_bib9) 2012; 76 Caberoy (10.1016/j.brainres.2013.10.049_bib11) 2010; 29 Skripuletz (10.1016/j.brainres.2013.10.049_bib90) 2013; 136 Cahoy (10.1016/j.brainres.2013.10.049_bib13) 2008; 28 Ramachandran (10.1016/j.brainres.2013.10.049_bib74) 2013; 52 Weinger (10.1016/j.brainres.2013.10.049_bib102) 2008; 106 Lai (10.1016/j.brainres.2013.10.049_bib42) 1991; 6 Prieto (10.1016/j.brainres.2013.10.049_bib71) 1999; 816 Jia (10.1016/j.brainres.2013.10.049_bib38) 1994; 269 Mark (10.1016/j.brainres.2013.10.049_bib58) 1994; 269 Taylor (10.1016/j.brainres.2013.10.049_bib92) 1995; 11 Binder (10.1016/j.brainres.2013.10.049_bib7) 2009; 17 Ling (10.1016/j.brainres.2013.10.049_bib49) 1995; 15 Brown (10.1016/j.brainres.2013.10.049_bib8) 2012; 7 Keating (10.1016/j.brainres.2013.10.049_bib40) 2010; 9 Lemke (10.1016/j.brainres.2013.10.049_bib45) 2008; 8 Sasaki (10.1016/j.brainres.2013.10.049_bib81) 2006; 25 Bellosta (10.1016/j.brainres.2013.10.049_bib4) 1997; 15 Pierce (10.1016/j.brainres.2013.10.049_bib69) 2011; 339 Varnum (10.1016/j.brainres.2013.10.049_bib97) 1995; 373 Liu (10.1016/j.brainres.2013.10.049_bib53) 1988; 85 Guttridge (10.1016/j.brainres.2013.10.049_bib31) 2002; 277 Tsiperson (10.1016/j.brainres.2013.10.049_bib94) 2010; 5 Janssen (10.1016/j.brainres.2013.10.049_bib36) 1991; 6 Graham (10.1016/j.brainres.2013.10.049_bib28) 2006; 12 Ohashi (10.1016/j.brainres.2013.10.049_bib65) 1994; 9 Walker (10.1016/j.brainres.2013.10.049_bib99) 2011; 84 Shankar (10.1016/j.brainres.2013.10.049_bib88) 2006; 26 Scott (10.1016/j.brainres.2013.10.049_bib86) 2001; 411 Ma (10.1016/j.brainres.2013.10.049_bib56) 2011; 6 Patin (10.1016/j.brainres.2013.10.049_bib67) 2012; 143 Prieto (10.1016/j.brainres.2013.10.049_bib72) 2000; 425 Lu (10.1016/j.brainres.2013.10.049_bib55) 2001; 293 Caberoy (10.1016/j.brainres.2013.10.049_bib10) 2009; 316 Weinger (10.1016/j.brainres.2013.10.049_bib103) 2009; 175 Migdall-Wilson (10.1016/j.brainres.2013.10.049_bib59) 2012; 7 Zhu (10.1016/j.brainres.2013.10.049_bib111) 2010; 115 Weier (10.1016/j.brainres.2013.10.049_bib101) 1999; 84 Chen (10.1016/j.brainres.2013.10.049_bib18) 2009; 138 Zheng (10.1016/j.brainres.2013.10.049_bib109) 2012; 7 Jia (10.1016/j.brainres.2013.10.049_bib37) 1992; 66 Chen (10.1016/j.brainres.2013.10.049_bib17) 1997; 14 Grommes (10.1016/j.brainres.2013.10.049_bib29) 2008; 3 Lewis (10.1016/j.brainres.2013.10.049_bib46) 1996; 31 Linger (10.1016/j.brainres.2013.10.049_bib52) 2008; 100 Ruan (10.1016/j.brainres.2013.10.049_bib79) 2012; 31 Ohashi (10.1016/j.brainres.2013.10.049_bib66) 1995; 117 Keating (10.1016/j.brainres.2013.10.049_bib39) 2006; 25 Graham (10.1016/j.brainres.2013.10.049_bib27) 1995; 10 Guo (10.1016/j.brainres.2013.10.049_bib30) 2011; 6 Lan (10.1016/j.brainres.2013.10.049_bib44) 2000; 95 Carr (10.1016/j.brainres.2013.10.049_bib15) 2009; 15 Singh (10.1016/j.brainres.2013.10.049_bib89) 2003; 63 Linger (10.1016/j.brainres.2013.10.049_bib51) 2010; 14 D’Cruz (10.1016/j.brainres.2013.10.049_bib19) 2000; 9 Taylor (10.1016/j.brainres.2013.10.049_bib93) 1995; 270 Biesecker (10.1016/j.brainres.2013.10.049_bib5) 1993; 90 Zhong (10.1016/j.brainres.2013.10.049_bib110) 2010; 30 Schneider (10.1016/j.brainres.2013.10.049_bib84) 1988; 54 Fujimoto (10.1016/j.brainres.2013.10.049_bib22) 1994; 9 Hafizi (10.1016/j.brainres.2013.10.049_bib32) 2006; 273 Lu (10.1016/j.brainres.2013.10.049_bib54) 1999; 398 Vajkoczy (10.1016/j.brainres.2013.10.049_bib95) 2006; 103 Li (10.1016/j.brainres.2013.10.049_bib47) 2013; 8 van den Brand (10.1016/j.brainres.2013.10.049_bib96) 2013; 65 Gal (10.1016/j.brainres.2013.10.049_bib24) 2000; 26 Verma (10.1016/j.brainres.2013.10.049_bib98) 2011; 10 Kilpatrick (10.1016/j.brainres.2013.10.049_bib41) 2000; 279 Camenisch (10.1016/j.brainres.2013.10.049_bib14) 1999; 162 Heiring (10.1016/j.brainres.2013.10.049_bib33) 2004; 279 Schlessinger (10.1016/j.brainres.2013.10.049_bib83) 2000; 103 Nielsen-Preiss (10.1016/j.brainres.2013.10.049_bib62) 2007; 148 Pierce (10.1016/j.brainres.2013.10.049_bib68) 2008; 22 O’Bryan (10.1016/j.brainres.2013.10.049_bib63) 1991; 11 Rothlin (10.1016/j.brainres.2013.10.049_bib77) 2007; 131 Prasad (10.1016/j.brainres.2013.10.049_bib70) 2006; 33 Carrera Silva (10.1016/j.brainres.2013.10.049_bib16) 2013; 39 Fridell (10.1016/j.brainres.2013.10.049_bib21) 1996; 16 Manfioletti (10.1016/j.brainres.2013.10.049_bib57) 1993; 13 O’Bryan (10.1016/j.brainres.2013.10.049_bib64) 1995; 270 Salian-Mehta (10.1016/j.brainres.2013.10.049_bib80) 2013; 374 Williams (10.1016/j.brainres.2013.10.049_bib105) 2007; 55 Goruppi (10.1016/j.brainres.2013.10.049_bib25) 1996; 12 Rothlin (10.1016/j.brainres.2013.10.049_bib78) 2010; 22 Xiong (10.1016/j.brainres.2013.10.049_bib107) 2008; 135 Graham (10.1016/j.brainres.2013.10.049_bib26) 1994; 5 Schulz (10.1016/j.brainres.2013.10.049_bib85) 1995; 28 Anwar (10.1016/j.brainres.2013.10.049_bib2) 2009; 86 Rescigno (10.1016/j.brainres.2013.10.049_bib75) 1991; 6 Stitt (10.1016/j.brainres.2013.10.049_bib91) 1995; 80 Duncan (10.1016/j.brainres.2013.10.049_bib20) 2003; 44 Ling (10.1016/j.brainres.2013.10.049_bib50) 1995; 15 Hutterer (10.1016/j.brainres.2013.10.049_bib35) 2008; 14 Prieto (10.1016/j.brainres.2013.10.049_bib73) 2007; 150 |
| References_xml | – volume: 5 start-page: e15748 year: 2010 ident: bib94 article-title: GAS6 enhances repair following cuprizone-induced demyelination publication-title: PLos ONE contributor: fullname: Tsiperson – volume: 31 start-page: 1692 year: 2012 end-page: 1703 ident: bib79 article-title: Axl is essential for VEGF-A-dependent activation of PI3K/Akt publication-title: EMBO J. contributor: fullname: Kazlauskas – volume: 15 start-page: 283 year: 2009 end-page: 295 ident: bib15 article-title: Molecular characterization and functional analysis of phagocytosis by human embryonic stem cell-derived RPE cells using a novel human retinal assay publication-title: Mol. Vis. contributor: fullname: Carr – volume: 411 start-page: 207 year: 2001 end-page: 211 ident: bib86 article-title: Phagocytosis and clearance of apoptotic cells is mediated by MER publication-title: Nature contributor: fullname: Scott – volume: 17 start-page: 277 year: 2009 end-page: 287 ident: bib7 article-title: TAM receptor signalling and demyelination publication-title: Neurosignals contributor: fullname: Kilpatrick – volume: 270 start-page: 551 year: 1995 end-page: 557 ident: bib64 article-title: The transforming receptor tyrosine kinase, Axl, is post-translationally regulated by proteolytic cleavage publication-title: J. Biol. Chem. contributor: fullname: O’Bryan – volume: 269 start-page: 10720 year: 1994 end-page: 10728 ident: bib58 article-title: rse, a novel receptor-type tyrosine kinase with homology to Axl/Ufo, is expressed at high levels in the brain publication-title: J. Biol. Chem. contributor: fullname: Mark – volume: 269 start-page: 1839 year: 1994 end-page: 1844 ident: bib38 article-title: The proto-oncogene of v- publication-title: J. Biol. Chem. contributor: fullname: Hanafusa – volume: 1240 start-page: 1 year: 2008 end-page: 11 ident: bib34 article-title: Axl-/- mice have delayed recovery and prolonged axonal damage following cuprizone toxicity publication-title: Brain Res. contributor: fullname: Hoehn – volume: 33 start-page: 96 year: 2006 end-page: 108 ident: bib70 article-title: TAM receptor function in the retinal pigment epithelium publication-title: Mol. Cell. Neurosci. contributor: fullname: Prasad – volume: 103 start-page: 5799 year: 2006 end-page: 5804 ident: bib95 article-title: Dominant-negative inhibition of the Axl receptor tyrosine kinase suppresses brain tumor cell growth and invasion and prolongs survival publication-title: Proc. Natl. Acad. Sci. USA contributor: fullname: Vajkoczy – volume: 162 start-page: 3498 year: 1999 end-page: 3503 ident: bib14 article-title: A novel receptor tyrosine kinase, Mer, inhibits TNF- publication-title: J. Immunol. contributor: fullname: Camenisch – volume: 22 start-page: 2481 year: 2008 end-page: 2495 ident: bib68 article-title: Axl and Tyro3 modulate female reproduction by influencing gonadotropin-releasing hormone neuron survival and migration publication-title: Mol. Endocrinol. contributor: fullname: Pierce – volume: 15 start-page: 2387 year: 1997 end-page: 2397 ident: bib4 article-title: Signaling through the ARK tyrosine kinase receptor protects from apoptosis in the absence of growth stimulation publication-title: Oncogene contributor: fullname: Bellosta – volume: 15 start-page: 6582 year: 1995 end-page: 6592 ident: bib49 article-title: Mitogenic signals and transforming potential of Nyk, a newly identified neural cell adhesion molecule-related receptor tyrosine kinase publication-title: Mol. Cell. Biol. contributor: fullname: Kung – volume: 39 start-page: 160 year: 2013 end-page: 170 ident: bib16 article-title: T cell-derived protein S engages TAM receptor signaling in dendritic cells to control the magnitude of the immune response publication-title: Immunity contributor: fullname: Carrera Silva – volume: 68 start-page: 150 year: 2002 end-page: 160 ident: bib23 article-title: Identification of Gas6, a putative ligand for Sky and Axl receptor tyrosine kinases, as a novel neurotrophic factor for hippocampal neurons publication-title: J. Neurosci. Res. contributor: fullname: Funakoshi – volume: 117 start-page: 1267 year: 1995 end-page: 1275 ident: bib66 article-title: Molecular cloning and in situ localization in the brain of rat sky receptor tyrosine kinase publication-title: J. Biochem. contributor: fullname: Ohashi – volume: 9 start-page: 2567 year: 1994 end-page: 2578 ident: bib43 article-title: Structure, expression, and activity of Tyro 3, a neural adhesion-related receptor tyrosine kinase publication-title: Oncogene contributor: fullname: Lemke – volume: 54 start-page: 787 year: 1988 end-page: 793 ident: bib84 article-title: Genes specifically expressed at growth arrest of mammalian cells publication-title: Cell contributor: fullname: Philipson – volume: 28 start-page: 5195 year: 2008 end-page: 5206 ident: bib6 article-title: Gas6 deficiency increases oligodendrocyte loss and microglial activation in response to cuprizone-induced demyelination publication-title: J. Neurosci. contributor: fullname: Binder – volume: 13 start-page: 191 year: 1999 end-page: 201 ident: bib1 article-title: Growth arrest-specific gene 6 (Gas6)/adhesion related kinase (Ark) signaling promotes gonadotropin-releasing hormone neuronal survival via extracellular signal-regulated kinase (ERK) and Akt publication-title: Mol Endocrinol. contributor: fullname: Allen – volume: 14 start-page: 1073 year: 2010 end-page: 1090 ident: bib51 article-title: Taking aim at Mer and Axl receptor tyrosine kinases as novel therapeutic targets in solid tumors publication-title: Expert Opin. Ther. Targets contributor: fullname: Linger – volume: 279 start-page: 6952 year: 2004 end-page: 6958 ident: bib33 article-title: Ligand Recognition and Homophilic Interactions in Tyro3 publication-title: J. Biol. Chem. contributor: fullname: Muller – volume: 100 start-page: 35 year: 2008 end-page: 83 ident: bib52 article-title: TAM receptor tyrosine kinases: biologic functions, signaling, and potential therapeutic targeting in human cancer publication-title: Adv. Cancer. Res. contributor: fullname: Linger – volume: 90 start-page: 7044 year: 1993 end-page: 7048 ident: bib5 article-title: Identification of four murine cDNAs encoding putative protein kinases from primitive embryonic stem cells differentiated in vitro publication-title: Proc. Natl. Acad. Sci. USA contributor: fullname: Emerson – volume: 7 start-page: e36800 year: 2012 ident: bib8 article-title: Cross-phosphorylation, signaling and proliferative functions of the Tyro3 and Axl receptors in Rat2 cells publication-title: PLoS One contributor: fullname: Brown – volume: 15 start-page: 6582 year: 1995 end-page: 6592 ident: bib50 article-title: Mitogenic signals and transforming potential of Nyk, a newly identified neural cell adhesion molecule-related receptor tyrosine kinase publication-title: Mol. Cell Biol. contributor: fullname: Kung – volume: 5 start-page: 647 year: 1994 end-page: 657 ident: bib26 article-title: Cloning and mRNA expression analysis of a novel human protooncogene, publication-title: Cell Growth Differ. contributor: fullname: Graham – volume: 55 start-page: 1300 year: 2007 end-page: 1312 ident: bib105 article-title: Astrocytes--friends or foes in multiple sclerosis? publication-title: Glia contributor: fullname: Lubetzki – volume: 85 start-page: 1952 year: 1988 end-page: 1956 ident: bib53 article-title: Transforming genes in chronic myelogenous leukemia publication-title: Proc. Natl. Acad. Sci. contributor: fullname: Bishop – volume: 3 start-page: 130 year: 2008 end-page: 140 ident: bib29 article-title: Regulation of microglial phagocytosis and inflammatory gene expression by Gas6 acting on the Axl/Mer family of tyrosine kinases publication-title: J. Neuroimmune Pharmacol. contributor: fullname: Grommes – volume: 6 start-page: e16964 year: 2011 ident: bib56 article-title: Polymorphisms in the receptor tyrosine kinase MERTK gene are associated with multiple sclerosis susceptibility publication-title: PLos ONE contributor: fullname: Ma – volume: 10 start-page: 1763 year: 2011 end-page: 1773 ident: bib98 article-title: Targeting Axl and Mer kinases in cancer publication-title: Mol. Cancer Ther. contributor: fullname: Verma – volume: 148 start-page: 2806 year: 2007 end-page: 2814 ident: bib62 article-title: Adhesion-related kinase induction of migration requires phosphatidylinositol-3-kinase and ras stimulation of rac activity in immortalized gonadotropin-releasing hormone neuronal cells publication-title: Endocrinology contributor: fullname: Nielsen-Preiss – volume: 16 start-page: 135 year: 1996 end-page: 145 ident: bib21 article-title: Differential activation of the Ras/extracellular-signal-regulated protein kinase pathway is responsible for the biological consequences induced by the Axl receptor tyrosine kinase publication-title: Mol. Cell Biol. contributor: fullname: Fridell – volume: 95 start-page: 633 year: 2000 end-page: 638 ident: bib44 article-title: Transforming activity of receptor tyrosine kinase tyro3 is mediated, at least in part, by the PI3 kinase-signaling pathway publication-title: Blood contributor: fullname: Lan – volume: 52 start-page: 4107 year: 2013 end-page: 4126 ident: bib74 article-title: Mechanistic studies unravel the complexity inherent in tau aggregation leading to Alzheimer’s disease and the tauopathies publication-title: Biochemistry contributor: fullname: Udgaonkar – volume: 25 start-page: 80 year: 2006 end-page: 87 ident: bib81 article-title: Structural basis for Gas6-Axl signalling publication-title: EMBO J. contributor: fullname: Sasaki – volume: 13 start-page: 4976 year: 1993 end-page: 4985 ident: bib57 article-title: The protein encoded by a growth arrest-specific gene ( publication-title: Mol. Cell. Biol. contributor: fullname: Manfioletti – volume: 8 start-page: 49 year: 2011 ident: bib104 article-title: Loss of the receptor tyrosine kinase Axl leads to enhanced inflammation in the CNS and delayed removal of myelin debris during experimental autoimmune encephalomyelitis publication-title: J. Neuroinflammation contributor: fullname: Weinger – volume: 80 start-page: 661 year: 1995 end-page: 670 ident: bib91 article-title: The anticoagulation factor protein S and its relative, Gas6, are ligands for the Tyro 3/Axl family of receptor tyrosine kinases publication-title: Cell contributor: fullname: Stitt – volume: 44 start-page: 826 year: 2003 end-page: 838 ident: bib20 article-title: An RCS-like retinal dystrophy phenotype in Mer knockout mice publication-title: Invest Ophthalmol. Vis. Sci. contributor: fullname: Duncan – volume: 9 start-page: 699 year: 1994 end-page: 705 ident: bib65 article-title: Cloning of the cDNA for a novel receptor tyrosine kinase, Sky, predominantly expressed in brain publication-title: Oncogene contributor: fullname: Ohashi – volume: 118 start-page: 539 year: 2005 end-page: 553 ident: bib106 article-title: A role for Mer tyrosine kinase in alphavbeta5 integrin-mediated phagocytosis of apoptotic cells publication-title: J. Cell Sci. contributor: fullname: Wu – volume: 14 start-page: 130 year: 2008 end-page: 138 ident: bib35 article-title: Axl and growth arrest-specific gene 6 are frequently overexpressed in human gliomas and predict poor prognosis in patients with glioblastoma multiforme publication-title: Clin. Cancer Res. contributor: fullname: Hutterer – year: 2012 ident: bib100 article-title: Mer receptor tyrosine kinase promotes invasion and survival in glioblastoma multiforme publication-title: Oncogene contributor: fullname: Wang – volume: 8 start-page: e64812 year: 2013 ident: bib47 article-title: Systemic autoimmunity in TAM triple knockout mice causes inflammatory brain damage and cell death publication-title: PLos ONE contributor: fullname: Li – volume: 103 start-page: 211 year: 2000 end-page: 225 ident: bib83 article-title: Cell signaling by receptor tyrosine kinases publication-title: Cell contributor: fullname: Schlessinger – volume: 277 start-page: 24057 year: 2002 end-page: 24066 ident: bib31 article-title: Receptor Tyrosine Kinase Signaling publication-title: J. Biol. Chem. contributor: fullname: Guttridge – volume: 279 start-page: 5 year: 2000 end-page: 8 ident: bib41 article-title: Rat oligodendroglia express c-met and focal adhesion kinase, protein tyrosine kinases implicated in regulating epithelial cell motility publication-title: Neurosci. Lett. contributor: fullname: Kilpatrick – volume: 816 start-page: 646 year: 1999 end-page: 661 ident: bib71 article-title: Gas6, a ligand for the receptor protein-tyrosine kinase Tyro-3, is widely expressed in the central nervous system publication-title: Brain Res. contributor: fullname: Prieto – volume: 16 start-page: 2012 year: 1996 end-page: 2019 ident: bib48 article-title: Identification of Gas-6 as a growth factor for human Schwann cells publication-title: J. Neurosci, contributor: fullname: Li – volume: 23 start-page: 506 year: 2004 end-page: 512 ident: bib60 article-title: Human vitamin K-dependent GAS6: gene structure, allelic variation, and association with stroke publication-title: Hum. Mutat. contributor: fullname: Munoz – volume: 43 start-page: 1289- year: 2002 end-page: 296 ident: bib108 article-title: Gas6 rescues cortical neurons from amyloid publication-title: Neuropharmacology contributor: fullname: Yagami – volume: 14 start-page: 2033 year: 1997 end-page: 2039 ident: bib17 article-title: Identification of Gas6 as a ligand for Mer, a neural cell adhesion moleculre related receptor tyrosine kinase implicated in cellular transformation publication-title: Oncogene contributor: fullname: Godowski – volume: 63 start-page: 5821 year: 2003 end-page: 5828 ident: bib89 article-title: Identification of a cancer stem cell in human brain tumors publication-title: Cancer Res. contributor: fullname: Singh – volume: 136 start-page: 147 year: 2013 end-page: 167 ident: bib90 article-title: Astrocytes regulate myelin clearance through recruitment of microglia during cuprizone-induced demyelination publication-title: Brain contributor: fullname: Skripuletz – volume: 10 start-page: 2349 year: 1995 end-page: 2359 ident: bib27 article-title: Cloning and developmental expression analysis of the murine c-mer tyrosine kinase publication-title: Oncogene contributor: fullname: Graham – volume: 135 start-page: 77 year: 2008 end-page: 87 ident: bib107 article-title: Gas6 and the Tyro 3 receptor tyrosine kinase subfamily regulate the phagocytic function of Sertoli cells publication-title: Reproduction contributor: fullname: Xiong – volume: 398 start-page: 723 year: 1999 end-page: 728 ident: bib54 article-title: Tyro-3 family receptors are essential regulators of mammalian spermatogenesis publication-title: Nature contributor: fullname: Lu – volume: 6 start-page: 1909 year: 1991 end-page: 1913 ident: bib75 article-title: A putative receptor tyrosine kinase with unique structural topology publication-title: Oncogene contributor: fullname: Mansukhani – volume: 131 start-page: 1124 year: 2007 end-page: 1136 ident: bib77 article-title: TAM receptors are pleiotropic inhibitors of the innate immune response publication-title: Cell contributor: fullname: Rothlin – volume: 28 start-page: 273 year: 1995 end-page: 280 ident: bib85 article-title: Isolation and expression analysis of tyro3, a murine growth factor receptor tyrosine kinase preferentially expressed in adult brain publication-title: Brain Res. Mol. Brain Res. contributor: fullname: Schulz – volume: 270 start-page: 6872 year: 1995 end-page: 6880 ident: bib93 article-title: Mouse mammary tumors express elevated levels of RNA encoding the murine homology of SKY, a putative receptor tyrosine kinase publication-title: J. Biol. Chem. contributor: fullname: Taylor – volume: 15 start-page: 614 year: 1995 end-page: 625 ident: bib3 article-title: The receptor tyrosine kinase ARK mediates cell aggregation by homophilic binding publication-title: Mol. Cell Biol. contributor: fullname: Bellosta – volume: 12 start-page: 471 year: 1996 end-page: 480 ident: bib25 article-title: Gas6, the ligand of Axl tyrosine kinase receptor, has mitogenic and survival activities for serum starved NIH3T3 fibroblasts publication-title: Oncogene contributor: fullname: Schneider – volume: 150 start-page: 319 year: 2007 end-page: 334 ident: bib73 article-title: Localization and signaling of the receptor protein tyrosine kinase Tyro3 in cortical and hippocampal neurons publication-title: Neuroscience contributor: fullname: Prieto – volume: 138 start-page: 655 year: 2009 end-page: 666 ident: bib18 article-title: Functions of TAM RTKs in regulating spermatogenesis and male fertility in mice publication-title: Reproduction contributor: fullname: Chen – volume: 106 start-page: 134 year: 2008 end-page: 146 ident: bib102 article-title: In brain, Axl recruits Grb2 and the p85 regulatory subunit of PI3 kinase; in vitro mutagenesis defines the requisite binding sites for downstream Akt activation publication-title: J. Neurochem. contributor: fullname: Weinger – volume: 76 start-page: 1123 year: 2012 end-page: 1132 ident: bib9 article-title: Genetic dissection of TAM receptor-ligand interaction in retinal pigment epithelial cell phagocytosis publication-title: Neuron contributor: fullname: Burstyn-Cohen – volume: 26 start-page: 5638 year: 2006 end-page: 5648 ident: bib88 article-title: Gas6/Axl Signaling Activates the Phosphatidylinositol 3-Kinase/Akt1 Survival Pathway to Protect Oligodendrocytes from Tumor Necrosis Factor publication-title: J. Neurosci. contributor: fullname: Shankar – volume: 11 start-page: 5016 year: 1991 end-page: 5031 ident: bib63 article-title: , a transforming gene isolated from primary human myeloid leukemia cells, encodes a novel receptor tyrosine kinase publication-title: Mol. Cell. Biol. contributor: fullname: O’Bryan – volume: 316 start-page: 245 year: 2009 end-page: 257 ident: bib10 article-title: Identification of tubby and tubby-like protein 1 as eat-me signals by phage display publication-title: Exp. Cell. Res. contributor: fullname: Caberoy – volume: 31 start-page: 4171 year: 2011 end-page: 4181 ident: bib76 article-title: Mer receptor tyrosine kinase inhibition impedes glioblastoma multiforme migration and alters cellular morphology publication-title: Oncogene contributor: fullname: Rogers – volume: 6 start-page: 2113 year: 1991 end-page: 2120 ident: bib36 article-title: A novel putataive tyrosine kinase receptor with oncogenic potential publication-title: Oncogene contributor: fullname: Janssen – volume: 374 start-page: 92 year: 2013 end-page: 100 ident: bib80 article-title: AXL and MET crosstalk to promote gonadotropin releasing hormone (GnRH) neuronal cell migration and survival publication-title: Mol. Cell Endocrinol. contributor: fullname: Wierman – volume: 175 start-page: 283 year: 2009 end-page: 293 ident: bib103 article-title: Up-regulation of soluble Axl and Mer receptor tyrosine kinases negatively correlates with Gas6 in established multiple sclerosis lesions publication-title: Am. J. Pathol. contributor: fullname: Weinger – volume: 22 start-page: 740 year: 2010 end-page: 746 ident: bib78 article-title: TAM receptor signaling and autoimmune disease publication-title: Curr. Opin. Immunol. contributor: fullname: Lemke – volume: 29 start-page: 3898 year: 2010 end-page: 3910 ident: bib11 article-title: Tubby and tubby-like protein 1 are new MerTK ligands for phagocytosis publication-title: EMBO. J. contributor: fullname: Zhou – volume: 26 start-page: 270 year: 2000 end-page: 271 ident: bib24 article-title: Mutations in MERTK, the human orthologue of the RCS rat retinal dystrophy gene, cause retinitis pigmentosa publication-title: Nat. Genet. contributor: fullname: Gal – volume: 9 start-page: 1298 year: 2010 end-page: 1307 ident: bib40 article-title: Inhibition of Mer and Axl receptor tyrosine kinases in astrocytoma cells leads to increased apoptosis and improved chemosensitivity publication-title: Mol. Cancer Ther. contributor: fullname: Keating – volume: 339 start-page: 151 year: 2011 end-page: 158 ident: bib69 article-title: Hypothalamic but not pituitary or ovarian defects underlie the reproductive abnormalities in publication-title: Mol. Cell. Endocrinol. contributor: fullname: Pierce – volume: 109 start-page: 1026 year: 2007 end-page: 1033 ident: bib82 article-title: A soluble form of the Mer receptor tyrosine kinase inhibits macrophage clearance of apoptotic cells and platelet aggregation publication-title: Blood contributor: fullname: Sather – volume: 7 start-page: e31635 year: 2012 ident: bib59 article-title: Prolonged exposure to a Mer ligand in leukemia: Gas6 favors expression of a partial Mer glycoform and reveals a novel role for Mer in the nucleus publication-title: PLoS One contributor: fullname: Migdall-Wilson – volume: 373 start-page: 623 year: 1995 end-page: 626 ident: bib97 article-title: Axl receptor tyrosine kinase stimulated by the vitamin K-dependent protein encoded by growth-arrest-specific gene 6 publication-title: Nature contributor: fullname: Varnum – volume: 293 start-page: 306 year: 2001 end-page: 311 ident: bib55 article-title: Homeostatic regulation of the immune system by receptor tyrosine kinases of the Tyro 3 family publication-title: Science contributor: fullname: Lemke – volume: 28 start-page: 264 year: 2008 end-page: 278 ident: bib13 article-title: A transcriptome database for astrocytes, neurons, and oligodendrocytes: a new resource for understanding brain development and function publication-title: J. Neurosci. contributor: fullname: Cahoy – volume: 12 start-page: 2662 year: 2006 end-page: 2669 ident: bib28 article-title: Ectopic expression of the proto-oncogene Mer in pediatric T-cell acute lymphoblastic leukemia publication-title: Clin. Cancer Res. contributor: fullname: Graham – volume: 143 start-page: 1244 year: 2012 end-page: 1252 ident: bib67 article-title: Genome-wide association study identifies variants associated with progression of liver fibrosis from HCV infection publication-title: Gastroenterology contributor: fullname: Patin – volume: 84 start-page: 91 year: 1999 end-page: 92 ident: bib101 article-title: Assignment of protooncogene MERTK (a.k.a. c-mer) to human chromosome 2q14.1 by in situ hybridization publication-title: Cytogenet. Cell Genet. contributor: fullname: Lersch – volume: 273 start-page: 5231 year: 2006 end-page: 5244 ident: bib32 article-title: Gas6 and protein S: vitamin K-dependent ligands for the Axl receptor tyrosine kinase subfamily publication-title: FEBS J. contributor: fullname: Dahlback – volume: 31 start-page: 13 year: 1996 end-page: 19 ident: bib46 article-title: Analysis of the murine Dtk gene identifies conservation of genomic structure within a new receptor tyrosine kinase subfamily publication-title: Genomics contributor: fullname: Lewis – volume: 66 start-page: 5975 year: 1992 end-page: 5987 ident: bib37 article-title: A novel oncogene, publication-title: J. Virol. contributor: fullname: Jia – volume: 23 start-page: 4208 year: 2003 end-page: 4218 ident: bib87 article-title: The Growth Arrest-Specific Gene Product Gas6 Promotes the Survival of Human Oligodendrocytes via a Phosphatidlyinositol 3-Kinase-Dependent Pathway publication-title: J. Neurosci. contributor: fullname: Shankar – volume: 84 start-page: S90 year: 2011 end-page: 106 ident: bib99 article-title: Biology, genetics and imaging of glial cell tumours publication-title: Br. J. Radiol. contributor: fullname: Walker – volume: 86 start-page: 73 year: 2009 end-page: 79 ident: bib2 article-title: Mer tyrosine kinase (MerTK) promotes macrophage survival following exposure to oxidative stress publication-title: J. Leukoc. Biol. contributor: fullname: Anwar – volume: 9 start-page: 693 year: 1994 end-page: 698 ident: bib22 article-title: brt, a mouse gene encoding a novel receptor-type proteintyrosine kinase, is preferentially expressed in the brain publication-title: Oncogene contributor: fullname: Yamamoto – volume: 25 start-page: 6092 year: 2006 end-page: 6100 ident: bib39 article-title: Lymphoblastic leukemia/lymphoma in mice overexpressing the Mer (MerTK) receptor tyrosine kinase publication-title: Oncogene contributor: fullname: Keating – volume: 8 start-page: 327 year: 2008 end-page: 336 ident: bib45 article-title: Immunobiology of the TAM receptors publication-title: Nat. Rev. Immunol. contributor: fullname: Rothlin – volume: 11 start-page: 2619 year: 1995 end-page: 2626 ident: bib92 article-title: Overexpression of the Sky receptor tyrosine kinase at the cell surface or in the cytoplasm results in ligand-independent activation publication-title: Oncogene contributor: fullname: Varmus – volume: 65 start-page: 671 year: 2013 end-page: 680 ident: bib96 article-title: Therapeutic efficacy of Tyro3, Axl, and Mer tyrosine kinase agonists in collagen-induced arthritis publication-title: Arthritis Rheum. contributor: fullname: van den Brand – volume: 115 start-page: 4963 year: 2010 end-page: 4972 ident: bib111 article-title: Protein S controls hypoxic/ischemic blood-brain barrier disuption through the TAM receptor Tyro3 and sphingosine 1-phosphate receptor publication-title: Blood contributor: fullname: Zhu – volume: 6 start-page: 13 year: 2011 ident: bib30 article-title: Protein S blocks the extrinsic apoptotic cascade in tissue plasminogen activator/N-methyl D-aspartate-treated neurons via Tyro3-Akt-FKHRL1 signaling pathway publication-title: Mol. Neurodegener. contributor: fullname: Guo – volume: 7 start-page: e39035 year: 2012 ident: bib109 article-title: Involvement of receptor tyrosine kinase Tyro3 in amyloidogenic APP processing and beta-amyloid deposition in Alzheimer’s disease models publication-title: PLos ONE contributor: fullname: Zheng – volume: 9 start-page: 645 year: 2000 end-page: 651 ident: bib19 article-title: Mutation of the receptor tyrosine kinase gene publication-title: Hum. Mol. Genet. contributor: fullname: D’Cruz – volume: 271 start-page: 30022 year: 1996 end-page: 30027 ident: bib61 article-title: Identification of the product of growth arrest-specific gene 6 as a common ligand for Axl, Sky, and Mer receptor tyrosine kinases publication-title: J. Biol. Chem. contributor: fullname: Nagata – volume: 425 start-page: 295 year: 2000 end-page: 314 ident: bib72 article-title: Expression of the receptor protein-tyrosine kinases Tyro-3, Axl, and mer in the developing rat central nervous system publication-title: J. Comp. Neurol. contributor: fullname: Lai – volume: 227 start-page: 401 year: 2012 end-page: 407 ident: bib12 article-title: Galectin-3 is a new mertk-specific eat-me signal publication-title: J. Cell. Physiol. contributor: fullname: Caberoy – volume: 6 start-page: 691 year: 1991 end-page: 704 ident: bib42 article-title: An extended family of protein-tyrosine kinase genes differentially expressed in the vertebrate nervous system publication-title: Neuron contributor: fullname: Lemke – volume: 30 start-page: 15521 year: 2010 end-page: 15534 ident: bib110 article-title: Protein S Protects Neurons from Excitotoxic Injury by Activating the TAM Receptor Tyro3-Phosphatidylinositol 3-Kinase-Akt Pathway through Its Sex Hormone-Binding Globulin-Like Region publication-title: Neurobiol. Dis. contributor: fullname: Zhong – volume: 3 start-page: 130 year: 2008 ident: 10.1016/j.brainres.2013.10.049_bib29 article-title: Regulation of microglial phagocytosis and inflammatory gene expression by Gas6 acting on the Axl/Mer family of tyrosine kinases publication-title: J. Neuroimmune Pharmacol. doi: 10.1007/s11481-007-9090-2 contributor: fullname: Grommes – volume: 33 start-page: 96 year: 2006 ident: 10.1016/j.brainres.2013.10.049_bib70 article-title: TAM receptor function in the retinal pigment epithelium publication-title: Mol. Cell. Neurosci. doi: 10.1016/j.mcn.2006.06.011 contributor: fullname: Prasad – volume: 227 start-page: 401 year: 2012 ident: 10.1016/j.brainres.2013.10.049_bib12 article-title: Galectin-3 is a new mertk-specific eat-me signal publication-title: J. Cell. Physiol. doi: 10.1002/jcp.22955 contributor: fullname: Caberoy – volume: 162 start-page: 3498 year: 1999 ident: 10.1016/j.brainres.2013.10.049_bib14 article-title: A novel receptor tyrosine kinase, Mer, inhibits TNF-α production and lipopolysaccharide-induced endotoxic shock publication-title: J. Immunol. doi: 10.4049/jimmunol.162.6.3498 contributor: fullname: Camenisch – volume: 54 start-page: 787 year: 1988 ident: 10.1016/j.brainres.2013.10.049_bib84 article-title: Genes specifically expressed at growth arrest of mammalian cells publication-title: Cell doi: 10.1016/S0092-8674(88)91065-3 contributor: fullname: Schneider – volume: 5 start-page: e15748 year: 2010 ident: 10.1016/j.brainres.2013.10.049_bib94 article-title: GAS6 enhances repair following cuprizone-induced demyelination publication-title: PLos ONE doi: 10.1371/journal.pone.0015748 contributor: fullname: Tsiperson – volume: 55 start-page: 1300 year: 2007 ident: 10.1016/j.brainres.2013.10.049_bib105 article-title: Astrocytes--friends or foes in multiple sclerosis? publication-title: Glia doi: 10.1002/glia.20546 contributor: fullname: Williams – volume: 277 start-page: 24057 year: 2002 ident: 10.1016/j.brainres.2013.10.049_bib31 article-title: Mer Receptor Tyrosine Kinase Signaling publication-title: J. Biol. Chem. doi: 10.1074/jbc.M112086200 contributor: fullname: Guttridge – volume: 52 start-page: 4107 year: 2013 ident: 10.1016/j.brainres.2013.10.049_bib74 article-title: Mechanistic studies unravel the complexity inherent in tau aggregation leading to Alzheimer’s disease and the tauopathies publication-title: Biochemistry doi: 10.1021/bi400209z contributor: fullname: Ramachandran – volume: 109 start-page: 1026 year: 2007 ident: 10.1016/j.brainres.2013.10.049_bib82 article-title: A soluble form of the Mer receptor tyrosine kinase inhibits macrophage clearance of apoptotic cells and platelet aggregation publication-title: Blood doi: 10.1182/blood-2006-05-021634 contributor: fullname: Sather – volume: 39 start-page: 160 year: 2013 ident: 10.1016/j.brainres.2013.10.049_bib16 article-title: T cell-derived protein S engages TAM receptor signaling in dendritic cells to control the magnitude of the immune response publication-title: Immunity doi: 10.1016/j.immuni.2013.06.010 contributor: fullname: Carrera Silva – volume: 6 start-page: e16964 year: 2011 ident: 10.1016/j.brainres.2013.10.049_bib56 article-title: Polymorphisms in the receptor tyrosine kinase MERTK gene are associated with multiple sclerosis susceptibility publication-title: PLos ONE doi: 10.1371/journal.pone.0016964 contributor: fullname: Ma – volume: 95 start-page: 633 year: 2000 ident: 10.1016/j.brainres.2013.10.049_bib44 article-title: Transforming activity of receptor tyrosine kinase tyro3 is mediated, at least in part, by the PI3 kinase-signaling pathway publication-title: Blood doi: 10.1182/blood.V95.2.633 contributor: fullname: Lan – volume: 65 start-page: 671 year: 2013 ident: 10.1016/j.brainres.2013.10.049_bib96 article-title: Therapeutic efficacy of Tyro3, Axl, and Mer tyrosine kinase agonists in collagen-induced arthritis publication-title: Arthritis Rheum. doi: 10.1002/art.37786 contributor: fullname: van den Brand – year: 2012 ident: 10.1016/j.brainres.2013.10.049_bib100 article-title: Mer receptor tyrosine kinase promotes invasion and survival in glioblastoma multiforme publication-title: Oncogene contributor: fullname: Wang – volume: 26 start-page: 5638 year: 2006 ident: 10.1016/j.brainres.2013.10.049_bib88 article-title: Gas6/Axl Signaling Activates the Phosphatidylinositol 3-Kinase/Akt1 Survival Pathway to Protect Oligodendrocytes from Tumor Necrosis Factorα-Induced Apoptosis publication-title: J. Neurosci. doi: 10.1523/JNEUROSCI.5063-05.2006 contributor: fullname: Shankar – volume: 7 start-page: e36800 year: 2012 ident: 10.1016/j.brainres.2013.10.049_bib8 article-title: Cross-phosphorylation, signaling and proliferative functions of the Tyro3 and Axl receptors in Rat2 cells publication-title: PLoS One doi: 10.1371/journal.pone.0036800 contributor: fullname: Brown – volume: 31 start-page: 4171 year: 2011 ident: 10.1016/j.brainres.2013.10.049_bib76 article-title: Mer receptor tyrosine kinase inhibition impedes glioblastoma multiforme migration and alters cellular morphology publication-title: Oncogene doi: 10.1038/onc.2011.588 contributor: fullname: Rogers – volume: 1240 start-page: 1 year: 2008 ident: 10.1016/j.brainres.2013.10.049_bib34 article-title: Axl-/- mice have delayed recovery and prolonged axonal damage following cuprizone toxicity publication-title: Brain Res. doi: 10.1016/j.brainres.2008.08.076 contributor: fullname: Hoehn – volume: 15 start-page: 6582 year: 1995 ident: 10.1016/j.brainres.2013.10.049_bib50 article-title: Mitogenic signals and transforming potential of Nyk, a newly identified neural cell adhesion molecule-related receptor tyrosine kinase publication-title: Mol. Cell Biol. doi: 10.1128/MCB.15.12.6582 contributor: fullname: Ling – volume: 16 start-page: 135 year: 1996 ident: 10.1016/j.brainres.2013.10.049_bib21 article-title: Differential activation of the Ras/extracellular-signal-regulated protein kinase pathway is responsible for the biological consequences induced by the Axl receptor tyrosine kinase publication-title: Mol. Cell Biol. doi: 10.1128/MCB.16.1.135 contributor: fullname: Fridell – volume: 6 start-page: 13 year: 2011 ident: 10.1016/j.brainres.2013.10.049_bib30 article-title: Protein S blocks the extrinsic apoptotic cascade in tissue plasminogen activator/N-methyl D-aspartate-treated neurons via Tyro3-Akt-FKHRL1 signaling pathway publication-title: Mol. Neurodegener. doi: 10.1186/1750-1326-6-13 contributor: fullname: Guo – volume: 115 start-page: 4963 year: 2010 ident: 10.1016/j.brainres.2013.10.049_bib111 article-title: Protein S controls hypoxic/ischemic blood-brain barrier disuption through the TAM receptor Tyro3 and sphingosine 1-phosphate receptor publication-title: Blood doi: 10.1182/blood-2010-01-262386 contributor: fullname: Zhu – volume: 816 start-page: 646 year: 1999 ident: 10.1016/j.brainres.2013.10.049_bib71 article-title: Gas6, a ligand for the receptor protein-tyrosine kinase Tyro-3, is widely expressed in the central nervous system publication-title: Brain Res. doi: 10.1016/S0006-8993(98)01159-7 contributor: fullname: Prieto – volume: 28 start-page: 264 year: 2008 ident: 10.1016/j.brainres.2013.10.049_bib13 article-title: A transcriptome database for astrocytes, neurons, and oligodendrocytes: a new resource for understanding brain development and function publication-title: J. Neurosci. doi: 10.1523/JNEUROSCI.4178-07.2008 contributor: fullname: Cahoy – volume: 31 start-page: 1692 year: 2012 ident: 10.1016/j.brainres.2013.10.049_bib79 article-title: Axl is essential for VEGF-A-dependent activation of PI3K/Akt publication-title: EMBO J. doi: 10.1038/emboj.2012.21 contributor: fullname: Ruan – volume: 23 start-page: 4208 year: 2003 ident: 10.1016/j.brainres.2013.10.049_bib87 article-title: The Growth Arrest-Specific Gene Product Gas6 Promotes the Survival of Human Oligodendrocytes via a Phosphatidlyinositol 3-Kinase-Dependent Pathway publication-title: J. Neurosci. doi: 10.1523/JNEUROSCI.23-10-04208.2003 contributor: fullname: Shankar – volume: 273 start-page: 5231 year: 2006 ident: 10.1016/j.brainres.2013.10.049_bib32 article-title: Gas6 and protein S: vitamin K-dependent ligands for the Axl receptor tyrosine kinase subfamily publication-title: FEBS J. doi: 10.1111/j.1742-4658.2006.05529.x contributor: fullname: Hafizi – volume: 10 start-page: 1763 year: 2011 ident: 10.1016/j.brainres.2013.10.049_bib98 article-title: Targeting Axl and Mer kinases in cancer publication-title: Mol. Cancer Ther. doi: 10.1158/1535-7163.MCT-11-0116 contributor: fullname: Verma – volume: 15 start-page: 2387 year: 1997 ident: 10.1016/j.brainres.2013.10.049_bib4 article-title: Signaling through the ARK tyrosine kinase receptor protects from apoptosis in the absence of growth stimulation publication-title: Oncogene doi: 10.1038/sj.onc.1201419 contributor: fullname: Bellosta – volume: 150 start-page: 319 year: 2007 ident: 10.1016/j.brainres.2013.10.049_bib73 article-title: Localization and signaling of the receptor protein tyrosine kinase Tyro3 in cortical and hippocampal neurons publication-title: Neuroscience doi: 10.1016/j.neuroscience.2007.09.047 contributor: fullname: Prieto – volume: 6 start-page: 1909 year: 1991 ident: 10.1016/j.brainres.2013.10.049_bib75 article-title: A putative receptor tyrosine kinase with unique structural topology publication-title: Oncogene contributor: fullname: Rescigno – volume: 103 start-page: 5799 year: 2006 ident: 10.1016/j.brainres.2013.10.049_bib95 article-title: Dominant-negative inhibition of the Axl receptor tyrosine kinase suppresses brain tumor cell growth and invasion and prolongs survival publication-title: Proc. Natl. Acad. Sci. USA doi: 10.1073/pnas.0510923103 contributor: fullname: Vajkoczy – volume: 11 start-page: 2619 year: 1995 ident: 10.1016/j.brainres.2013.10.049_bib92 article-title: Overexpression of the Sky receptor tyrosine kinase at the cell surface or in the cytoplasm results in ligand-independent activation publication-title: Oncogene contributor: fullname: Taylor – volume: 15 start-page: 6582 year: 1995 ident: 10.1016/j.brainres.2013.10.049_bib49 article-title: Mitogenic signals and transforming potential of Nyk, a newly identified neural cell adhesion molecule-related receptor tyrosine kinase publication-title: Mol. Cell. Biol. doi: 10.1128/MCB.15.12.6582 contributor: fullname: Ling – volume: 26 start-page: 270 year: 2000 ident: 10.1016/j.brainres.2013.10.049_bib24 article-title: Mutations in MERTK, the human orthologue of the RCS rat retinal dystrophy gene, cause retinitis pigmentosa publication-title: Nat. Genet. doi: 10.1038/81555 contributor: fullname: Gal – volume: 270 start-page: 551 year: 1995 ident: 10.1016/j.brainres.2013.10.049_bib64 article-title: The transforming receptor tyrosine kinase, Axl, is post-translationally regulated by proteolytic cleavage publication-title: J. Biol. Chem. doi: 10.1074/jbc.270.2.551 contributor: fullname: O’Bryan – volume: 13 start-page: 4976 year: 1993 ident: 10.1016/j.brainres.2013.10.049_bib57 article-title: The protein encoded by a growth arrest-specific gene (gas6) is a new member of the vitamin k-dependent proteins related to protein S, a negative coregulator in the blood coagulation cascade publication-title: Mol. Cell. Biol. doi: 10.1128/MCB.13.8.4976 contributor: fullname: Manfioletti – volume: 14 start-page: 1073 year: 2010 ident: 10.1016/j.brainres.2013.10.049_bib51 article-title: Taking aim at Mer and Axl receptor tyrosine kinases as novel therapeutic targets in solid tumors publication-title: Expert Opin. Ther. Targets doi: 10.1517/14728222.2010.515980 contributor: fullname: Linger – volume: 411 start-page: 207 year: 2001 ident: 10.1016/j.brainres.2013.10.049_bib86 article-title: Phagocytosis and clearance of apoptotic cells is mediated by MER publication-title: Nature doi: 10.1038/35075603 contributor: fullname: Scott – volume: 9 start-page: 2567 year: 1994 ident: 10.1016/j.brainres.2013.10.049_bib43 article-title: Structure, expression, and activity of Tyro 3, a neural adhesion-related receptor tyrosine kinase publication-title: Oncogene contributor: fullname: Lai – volume: 100 start-page: 35 year: 2008 ident: 10.1016/j.brainres.2013.10.049_bib52 article-title: TAM receptor tyrosine kinases: biologic functions, signaling, and potential therapeutic targeting in human cancer publication-title: Adv. Cancer. Res. doi: 10.1016/S0065-230X(08)00002-X contributor: fullname: Linger – volume: 293 start-page: 306 year: 2001 ident: 10.1016/j.brainres.2013.10.049_bib55 article-title: Homeostatic regulation of the immune system by receptor tyrosine kinases of the Tyro 3 family publication-title: Science doi: 10.1126/science.1061663 contributor: fullname: Lu – volume: 14 start-page: 130 year: 2008 ident: 10.1016/j.brainres.2013.10.049_bib35 article-title: Axl and growth arrest-specific gene 6 are frequently overexpressed in human gliomas and predict poor prognosis in patients with glioblastoma multiforme publication-title: Clin. Cancer Res. doi: 10.1158/1078-0432.CCR-07-0862 contributor: fullname: Hutterer – volume: 271 start-page: 30022 year: 1996 ident: 10.1016/j.brainres.2013.10.049_bib61 article-title: Identification of the product of growth arrest-specific gene 6 as a common ligand for Axl, Sky, and Mer receptor tyrosine kinases publication-title: J. Biol. Chem. doi: 10.1074/jbc.271.47.30022 contributor: fullname: Nagata – volume: 269 start-page: 10720 year: 1994 ident: 10.1016/j.brainres.2013.10.049_bib58 article-title: rse, a novel receptor-type tyrosine kinase with homology to Axl/Ufo, is expressed at high levels in the brain publication-title: J. Biol. Chem. doi: 10.1016/S0021-9258(17)34118-2 contributor: fullname: Mark – volume: 25 start-page: 80 year: 2006 ident: 10.1016/j.brainres.2013.10.049_bib81 article-title: Structural basis for Gas6-Axl signalling publication-title: EMBO J. doi: 10.1038/sj.emboj.7600912 contributor: fullname: Sasaki – volume: 7 start-page: e31635 year: 2012 ident: 10.1016/j.brainres.2013.10.049_bib59 article-title: Prolonged exposure to a Mer ligand in leukemia: Gas6 favors expression of a partial Mer glycoform and reveals a novel role for Mer in the nucleus publication-title: PLoS One doi: 10.1371/journal.pone.0031635 contributor: fullname: Migdall-Wilson – volume: 118 start-page: 539 year: 2005 ident: 10.1016/j.brainres.2013.10.049_bib106 article-title: A role for Mer tyrosine kinase in alphavbeta5 integrin-mediated phagocytosis of apoptotic cells publication-title: J. Cell Sci. doi: 10.1242/jcs.01632 contributor: fullname: Wu – volume: 22 start-page: 2481 year: 2008 ident: 10.1016/j.brainres.2013.10.049_bib68 article-title: Axl and Tyro3 modulate female reproduction by influencing gonadotropin-releasing hormone neuron survival and migration publication-title: Mol. Endocrinol. doi: 10.1210/me.2008-0169 contributor: fullname: Pierce – volume: 138 start-page: 655 year: 2009 ident: 10.1016/j.brainres.2013.10.049_bib18 article-title: Functions of TAM RTKs in regulating spermatogenesis and male fertility in mice publication-title: Reproduction doi: 10.1530/REP-09-0101 contributor: fullname: Chen – volume: 8 start-page: 327 year: 2008 ident: 10.1016/j.brainres.2013.10.049_bib45 article-title: Immunobiology of the TAM receptors publication-title: Nat. Rev. Immunol. doi: 10.1038/nri2303 contributor: fullname: Lemke – volume: 16 start-page: 2012 year: 1996 ident: 10.1016/j.brainres.2013.10.049_bib48 article-title: Identification of Gas-6 as a growth factor for human Schwann cells publication-title: J. Neurosci, doi: 10.1523/JNEUROSCI.16-06-02012.1996 contributor: fullname: Li – volume: 9 start-page: 645 year: 2000 ident: 10.1016/j.brainres.2013.10.049_bib19 article-title: Mutation of the receptor tyrosine kinase gene Mertk in the retinal dystrophoic RCS rat publication-title: Hum. Mol. Genet. doi: 10.1093/hmg/9.4.645 contributor: fullname: D’Cruz – volume: 11 start-page: 5016 year: 1991 ident: 10.1016/j.brainres.2013.10.049_bib63 article-title: axl, a transforming gene isolated from primary human myeloid leukemia cells, encodes a novel receptor tyrosine kinase publication-title: Mol. Cell. Biol. doi: 10.1128/MCB.11.10.5016 contributor: fullname: O’Bryan – volume: 9 start-page: 699 year: 1994 ident: 10.1016/j.brainres.2013.10.049_bib65 article-title: Cloning of the cDNA for a novel receptor tyrosine kinase, Sky, predominantly expressed in brain publication-title: Oncogene contributor: fullname: Ohashi – volume: 103 start-page: 211 year: 2000 ident: 10.1016/j.brainres.2013.10.049_bib83 article-title: Cell signaling by receptor tyrosine kinases publication-title: Cell doi: 10.1016/S0092-8674(00)00114-8 contributor: fullname: Schlessinger – volume: 9 start-page: 693 year: 1994 ident: 10.1016/j.brainres.2013.10.049_bib22 article-title: brt, a mouse gene encoding a novel receptor-type proteintyrosine kinase, is preferentially expressed in the brain publication-title: Oncogene contributor: fullname: Fujimoto – volume: 6 start-page: 2113 year: 1991 ident: 10.1016/j.brainres.2013.10.049_bib36 article-title: A novel putataive tyrosine kinase receptor with oncogenic potential publication-title: Oncogene contributor: fullname: Janssen – volume: 15 start-page: 614 year: 1995 ident: 10.1016/j.brainres.2013.10.049_bib3 article-title: The receptor tyrosine kinase ARK mediates cell aggregation by homophilic binding publication-title: Mol. Cell Biol. doi: 10.1128/MCB.15.2.614 contributor: fullname: Bellosta – volume: 6 start-page: 691 year: 1991 ident: 10.1016/j.brainres.2013.10.049_bib42 article-title: An extended family of protein-tyrosine kinase genes differentially expressed in the vertebrate nervous system publication-title: Neuron doi: 10.1016/0896-6273(91)90167-X contributor: fullname: Lai – volume: 5 start-page: 647 year: 1994 ident: 10.1016/j.brainres.2013.10.049_bib26 article-title: Cloning and mRNA expression analysis of a novel human protooncogene, c-mer publication-title: Cell Growth Differ. contributor: fullname: Graham – volume: 15 start-page: 283 year: 2009 ident: 10.1016/j.brainres.2013.10.049_bib15 article-title: Molecular characterization and functional analysis of phagocytosis by human embryonic stem cell-derived RPE cells using a novel human retinal assay publication-title: Mol. Vis. contributor: fullname: Carr – volume: 44 start-page: 826 year: 2003 ident: 10.1016/j.brainres.2013.10.049_bib20 article-title: An RCS-like retinal dystrophy phenotype in Mer knockout mice publication-title: Invest Ophthalmol. Vis. Sci. doi: 10.1167/iovs.02-0438 contributor: fullname: Duncan – volume: 84 start-page: 91 year: 1999 ident: 10.1016/j.brainres.2013.10.049_bib101 article-title: Assignment of protooncogene MERTK (a.k.a. c-mer) to human chromosome 2q14.1 by in situ hybridization publication-title: Cytogenet. Cell Genet. doi: 10.1159/000015223 contributor: fullname: Weier – volume: 28 start-page: 5195 year: 2008 ident: 10.1016/j.brainres.2013.10.049_bib6 article-title: Gas6 deficiency increases oligodendrocyte loss and microglial activation in response to cuprizone-induced demyelination publication-title: J. Neurosci. doi: 10.1523/JNEUROSCI.1180-08.2008 contributor: fullname: Binder – volume: 269 start-page: 1839 year: 1994 ident: 10.1016/j.brainres.2013.10.049_bib38 article-title: The proto-oncogene of v-eyk (v-ryk) is a novel receptor-type protein tyrosine kinase with extracellular Ig/FN-III domains publication-title: J. Biol. Chem. doi: 10.1016/S0021-9258(17)42103-X contributor: fullname: Jia – volume: 63 start-page: 5821 year: 2003 ident: 10.1016/j.brainres.2013.10.049_bib89 article-title: Identification of a cancer stem cell in human brain tumors publication-title: Cancer Res. contributor: fullname: Singh – volume: 339 start-page: 151 year: 2011 ident: 10.1016/j.brainres.2013.10.049_bib69 article-title: Hypothalamic but not pituitary or ovarian defects underlie the reproductive abnormalities in Axl/Tyro3 null mice publication-title: Mol. Cell. Endocrinol. doi: 10.1016/j.mce.2011.04.007 contributor: fullname: Pierce – volume: 23 start-page: 506 year: 2004 ident: 10.1016/j.brainres.2013.10.049_bib60 article-title: Human vitamin K-dependent GAS6: gene structure, allelic variation, and association with stroke publication-title: Hum. Mutat. doi: 10.1002/humu.20025 contributor: fullname: Munoz – volume: 25 start-page: 6092 year: 2006 ident: 10.1016/j.brainres.2013.10.049_bib39 article-title: Lymphoblastic leukemia/lymphoma in mice overexpressing the Mer (MerTK) receptor tyrosine kinase publication-title: Oncogene doi: 10.1038/sj.onc.1209633 contributor: fullname: Keating – volume: 106 start-page: 134 year: 2008 ident: 10.1016/j.brainres.2013.10.049_bib102 article-title: In brain, Axl recruits Grb2 and the p85 regulatory subunit of PI3 kinase; in vitro mutagenesis defines the requisite binding sites for downstream Akt activation publication-title: J. Neurochem. doi: 10.1111/j.1471-4159.2008.05343.x contributor: fullname: Weinger – volume: 14 start-page: 2033 year: 1997 ident: 10.1016/j.brainres.2013.10.049_bib17 article-title: Identification of Gas6 as a ligand for Mer, a neural cell adhesion moleculre related receptor tyrosine kinase implicated in cellular transformation publication-title: Oncogene doi: 10.1038/sj.onc.1201039 contributor: fullname: Chen – volume: 68 start-page: 150 year: 2002 ident: 10.1016/j.brainres.2013.10.049_bib23 article-title: Identification of Gas6, a putative ligand for Sky and Axl receptor tyrosine kinases, as a novel neurotrophic factor for hippocampal neurons publication-title: J. Neurosci. Res. doi: 10.1002/jnr.10211 contributor: fullname: Funakoshi – volume: 12 start-page: 471 year: 1996 ident: 10.1016/j.brainres.2013.10.049_bib25 article-title: Gas6, the ligand of Axl tyrosine kinase receptor, has mitogenic and survival activities for serum starved NIH3T3 fibroblasts publication-title: Oncogene contributor: fullname: Goruppi – volume: 12 start-page: 2662 year: 2006 ident: 10.1016/j.brainres.2013.10.049_bib28 article-title: Ectopic expression of the proto-oncogene Mer in pediatric T-cell acute lymphoblastic leukemia publication-title: Clin. Cancer Res. doi: 10.1158/1078-0432.CCR-05-2208 contributor: fullname: Graham – volume: 30 start-page: 15521 year: 2010 ident: 10.1016/j.brainres.2013.10.049_bib110 article-title: Protein S Protects Neurons from Excitotoxic Injury by Activating the TAM Receptor Tyro3-Phosphatidylinositol 3-Kinase-Akt Pathway through Its Sex Hormone-Binding Globulin-Like Region publication-title: Neurobiol. Dis. contributor: fullname: Zhong – volume: 175 start-page: 283 year: 2009 ident: 10.1016/j.brainres.2013.10.049_bib103 article-title: Up-regulation of soluble Axl and Mer receptor tyrosine kinases negatively correlates with Gas6 in established multiple sclerosis lesions publication-title: Am. J. Pathol. doi: 10.2353/ajpath.2009.080807 contributor: fullname: Weinger – volume: 17 start-page: 277 year: 2009 ident: 10.1016/j.brainres.2013.10.049_bib7 article-title: TAM receptor signalling and demyelination publication-title: Neurosignals doi: 10.1159/000231894 contributor: fullname: Binder – volume: 117 start-page: 1267 year: 1995 ident: 10.1016/j.brainres.2013.10.049_bib66 article-title: Molecular cloning and in situ localization in the brain of rat sky receptor tyrosine kinase publication-title: J. Biochem. doi: 10.1093/oxfordjournals.jbchem.a124854 contributor: fullname: Ohashi – volume: 29 start-page: 3898 year: 2010 ident: 10.1016/j.brainres.2013.10.049_bib11 article-title: Tubby and tubby-like protein 1 are new MerTK ligands for phagocytosis publication-title: EMBO. J. doi: 10.1038/emboj.2010.265 contributor: fullname: Caberoy – volume: 8 start-page: e64812 year: 2013 ident: 10.1016/j.brainres.2013.10.049_bib47 article-title: Systemic autoimmunity in TAM triple knockout mice causes inflammatory brain damage and cell death publication-title: PLos ONE doi: 10.1371/journal.pone.0064812 contributor: fullname: Li – volume: 76 start-page: 1123 year: 2012 ident: 10.1016/j.brainres.2013.10.049_bib9 article-title: Genetic dissection of TAM receptor-ligand interaction in retinal pigment epithelial cell phagocytosis publication-title: Neuron doi: 10.1016/j.neuron.2012.10.015 contributor: fullname: Burstyn-Cohen – volume: 279 start-page: 6952 year: 2004 ident: 10.1016/j.brainres.2013.10.049_bib33 article-title: Ligand Recognition and Homophilic Interactions in Tyro3 publication-title: J. Biol. Chem. doi: 10.1074/jbc.M311750200 contributor: fullname: Heiring – volume: 86 start-page: 73 year: 2009 ident: 10.1016/j.brainres.2013.10.049_bib2 article-title: Mer tyrosine kinase (MerTK) promotes macrophage survival following exposure to oxidative stress publication-title: J. Leukoc. Biol. doi: 10.1189/jlb.0608334 contributor: fullname: Anwar – volume: 8 start-page: 49 year: 2011 ident: 10.1016/j.brainres.2013.10.049_bib104 article-title: Loss of the receptor tyrosine kinase Axl leads to enhanced inflammation in the CNS and delayed removal of myelin debris during experimental autoimmune encephalomyelitis publication-title: J. Neuroinflammation doi: 10.1186/1742-2094-8-49 contributor: fullname: Weinger – volume: 135 start-page: 77 year: 2008 ident: 10.1016/j.brainres.2013.10.049_bib107 article-title: Gas6 and the Tyro 3 receptor tyrosine kinase subfamily regulate the phagocytic function of Sertoli cells publication-title: Reproduction doi: 10.1530/REP-07-0287 contributor: fullname: Xiong – volume: 148 start-page: 2806 year: 2007 ident: 10.1016/j.brainres.2013.10.049_bib62 article-title: Adhesion-related kinase induction of migration requires phosphatidylinositol-3-kinase and ras stimulation of rac activity in immortalized gonadotropin-releasing hormone neuronal cells publication-title: Endocrinology doi: 10.1210/en.2007-0039 contributor: fullname: Nielsen-Preiss – volume: 316 start-page: 245 year: 2009 ident: 10.1016/j.brainres.2013.10.049_bib10 article-title: Identification of tubby and tubby-like protein 1 as eat-me signals by phage display publication-title: Exp. Cell. Res. doi: 10.1016/j.yexcr.2009.10.008 contributor: fullname: Caberoy – volume: 10 start-page: 2349 year: 1995 ident: 10.1016/j.brainres.2013.10.049_bib27 article-title: Cloning and developmental expression analysis of the murine c-mer tyrosine kinase publication-title: Oncogene contributor: fullname: Graham – volume: 143 start-page: 1244 year: 2012 ident: 10.1016/j.brainres.2013.10.049_bib67 article-title: Genome-wide association study identifies variants associated with progression of liver fibrosis from HCV infection publication-title: Gastroenterology doi: 10.1053/j.gastro.2012.07.097 contributor: fullname: Patin – volume: 131 start-page: 1124 year: 2007 ident: 10.1016/j.brainres.2013.10.049_bib77 article-title: TAM receptors are pleiotropic inhibitors of the innate immune response publication-title: Cell doi: 10.1016/j.cell.2007.10.034 contributor: fullname: Rothlin – volume: 80 start-page: 661 year: 1995 ident: 10.1016/j.brainres.2013.10.049_bib91 article-title: The anticoagulation factor protein S and its relative, Gas6, are ligands for the Tyro 3/Axl family of receptor tyrosine kinases publication-title: Cell doi: 10.1016/0092-8674(95)90520-0 contributor: fullname: Stitt – volume: 22 start-page: 740 year: 2010 ident: 10.1016/j.brainres.2013.10.049_bib78 article-title: TAM receptor signaling and autoimmune disease publication-title: Curr. Opin. Immunol. doi: 10.1016/j.coi.2010.10.001 contributor: fullname: Rothlin – volume: 66 start-page: 5975 year: 1992 ident: 10.1016/j.brainres.2013.10.049_bib37 article-title: A novel oncogene, v-ryk, encoding a truncated receptor tyrosine kinase is transduced into the rpl30 virus without loss of viral sequences publication-title: J. Virol. doi: 10.1128/JVI.66.10.5975-5987.1992 contributor: fullname: Jia – volume: 84 start-page: S90 issue: 2 year: 2011 ident: 10.1016/j.brainres.2013.10.049_bib99 article-title: Biology, genetics and imaging of glial cell tumours publication-title: Br. J. Radiol. doi: 10.1259/bjr/23430927 contributor: fullname: Walker – volume: 373 start-page: 623 year: 1995 ident: 10.1016/j.brainres.2013.10.049_bib97 article-title: Axl receptor tyrosine kinase stimulated by the vitamin K-dependent protein encoded by growth-arrest-specific gene 6 publication-title: Nature doi: 10.1038/373623a0 contributor: fullname: Varnum – volume: 13 start-page: 191 year: 1999 ident: 10.1016/j.brainres.2013.10.049_bib1 article-title: Growth arrest-specific gene 6 (Gas6)/adhesion related kinase (Ark) signaling promotes gonadotropin-releasing hormone neuronal survival via extracellular signal-regulated kinase (ERK) and Akt publication-title: Mol Endocrinol. doi: 10.1210/mend.13.2.0230 contributor: fullname: Allen – volume: 85 start-page: 1952 year: 1988 ident: 10.1016/j.brainres.2013.10.049_bib53 article-title: Transforming genes in chronic myelogenous leukemia publication-title: Proc. Natl. Acad. Sci. doi: 10.1073/pnas.85.6.1952 contributor: fullname: Liu – volume: 28 start-page: 273 year: 1995 ident: 10.1016/j.brainres.2013.10.049_bib85 article-title: Isolation and expression analysis of tyro3, a murine growth factor receptor tyrosine kinase preferentially expressed in adult brain publication-title: Brain Res. Mol. Brain Res. doi: 10.1016/0169-328X(94)00216-2 contributor: fullname: Schulz – volume: 374 start-page: 92 year: 2013 ident: 10.1016/j.brainres.2013.10.049_bib80 article-title: AXL and MET crosstalk to promote gonadotropin releasing hormone (GnRH) neuronal cell migration and survival publication-title: Mol. Cell Endocrinol. doi: 10.1016/j.mce.2013.04.018 contributor: fullname: Salian-Mehta – volume: 7 start-page: e39035 year: 2012 ident: 10.1016/j.brainres.2013.10.049_bib109 article-title: Involvement of receptor tyrosine kinase Tyro3 in amyloidogenic APP processing and beta-amyloid deposition in Alzheimer’s disease models publication-title: PLos ONE doi: 10.1371/journal.pone.0039035 contributor: fullname: Zheng – volume: 9 start-page: 1298 year: 2010 ident: 10.1016/j.brainres.2013.10.049_bib40 article-title: Inhibition of Mer and Axl receptor tyrosine kinases in astrocytoma cells leads to increased apoptosis and improved chemosensitivity publication-title: Mol. Cancer Ther. doi: 10.1158/1535-7163.MCT-09-0707 contributor: fullname: Keating – volume: 90 start-page: 7044 year: 1993 ident: 10.1016/j.brainres.2013.10.049_bib5 article-title: Identification of four murine cDNAs encoding putative protein kinases from primitive embryonic stem cells differentiated in vitro publication-title: Proc. Natl. Acad. Sci. USA doi: 10.1073/pnas.90.15.7044 contributor: fullname: Biesecker – volume: 270 start-page: 6872 year: 1995 ident: 10.1016/j.brainres.2013.10.049_bib93 article-title: Mouse mammary tumors express elevated levels of RNA encoding the murine homology of SKY, a putative receptor tyrosine kinase publication-title: J. Biol. Chem. doi: 10.1074/jbc.270.12.6872 contributor: fullname: Taylor – volume: 136 start-page: 147 year: 2013 ident: 10.1016/j.brainres.2013.10.049_bib90 article-title: Astrocytes regulate myelin clearance through recruitment of microglia during cuprizone-induced demyelination publication-title: Brain doi: 10.1093/brain/aws262 contributor: fullname: Skripuletz – volume: 31 start-page: 13 year: 1996 ident: 10.1016/j.brainres.2013.10.049_bib46 article-title: Analysis of the murine Dtk gene identifies conservation of genomic structure within a new receptor tyrosine kinase subfamily publication-title: Genomics doi: 10.1006/geno.1996.0003 contributor: fullname: Lewis – volume: 425 start-page: 295 year: 2000 ident: 10.1016/j.brainres.2013.10.049_bib72 article-title: Expression of the receptor protein-tyrosine kinases Tyro-3, Axl, and mer in the developing rat central nervous system publication-title: J. Comp. Neurol. doi: 10.1002/1096-9861(20000918)425:2<295::AID-CNE11>3.0.CO;2-G contributor: fullname: Prieto – volume: 43 start-page: 1289- year: 2002 ident: 10.1016/j.brainres.2013.10.049_bib108 article-title: Gas6 rescues cortical neurons from amyloid β protein-induced apoptosis publication-title: Neuropharmacology doi: 10.1016/S0028-3908(02)00333-7 contributor: fullname: Yagami – volume: 398 start-page: 723 year: 1999 ident: 10.1016/j.brainres.2013.10.049_bib54 article-title: Tyro-3 family receptors are essential regulators of mammalian spermatogenesis publication-title: Nature doi: 10.1038/19554 contributor: fullname: Lu – volume: 279 start-page: 5 year: 2000 ident: 10.1016/j.brainres.2013.10.049_bib41 article-title: Rat oligodendroglia express c-met and focal adhesion kinase, protein tyrosine kinases implicated in regulating epithelial cell motility publication-title: Neurosci. Lett. doi: 10.1016/S0304-3940(99)00928-3 contributor: fullname: Kilpatrick |
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| Snippet | Abstract Receptor tyrosine kinases (RTKs) are cell surface proteins that tightly regulate a variety of downstream intra-cellular processes; ligand-receptor... Receptor tyrosine kinases (RTKs) are cell surface proteins that tightly regulate a variety of downstream intra-cellular processes; ligand-receptor interactions... |
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| SubjectTerms | Adult and adolescent clinical studies Alzheimer's disease Animals Biological and medical sciences Carcinogenesis - genetics Cell signaling Central Nervous System - metabolism Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Developmental neurology Glioblastoma Humans Medical sciences Multiple sclerosis Neurology Organic mental disorders. Neuropsychology Protein-Tyrosine Kinases - metabolism Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Receptor Protein-Tyrosine Kinases - metabolism Signal Transduction - drug effects Signal Transduction - immunology Signal Transduction - physiology |
| Title | TAM receptor tyrosine kinases: Expression, disease and oncogenesis in the central nervous system |
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