IL-13 is a central mediator of chemical-induced airway hyperreactivity in mice

• Published in: PloS one Vol. 12; no. 7; p. e0180690
• Main Authors: Devos, Fien C, Pollaris, Lore, Cremer, Jonathan, Seys, Sven, Hoshino, Tomoaki, Ceuppens, Jan, Talavera, Karel, Nemery, Benoit, Hoet, Peter H M, Vanoirbeek, Jeroen A J
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 13.07.2017; Public Library of Science (PLoS)
• Subjects: Acetone; Allergies; Animals; Antibodies - administration & dosage; Antibodies - pharmacology; Asthma; Asthma - chemically induced; Asthma - drug therapy; Asthma - immunology; Attorneys; Biology and Life Sciences; Cytokines; Development and progression; Disease Models, Animal; Genotype & phenotype; Health aspects; Hypersensitivity; Immunoglobulin E; Immunoglobulin E - blood; Immunology; Inflammation; Interleukin 13; Interleukin-13 - antagonists & inhibitors; Interleukin-13 - genetics; Laboratories; Lymph nodes; Lymphocytes; Lymphocytes B; Lymphocytes T; Male; Measurement; Medicine and Health Sciences; Methacholine; Mice; Mice, Inbred C57BL; Mice, Knockout; Oils & fats; Olive oil; Patients; Primary care; Public health; Receiving; Research and Analysis Methods; Respiratory tract; Risk factors; Rodents; Smooth muscle; Toluene; Toluene 2,4-Diisocyanate - adverse effects; Belgium

While the importance of the Th2 cytokine IL-13 as a central mediator of airway hyperreactivity (AHR) has been described in allergic protein-induced asthma, this has never been investigated in chemical-induced asthma. We examined the importance of IL-13 in a mouse model of chemical-induced AHR, using...