Ethanol locks for the prevention of catheter-related infection in patients with central venous catheter: A systematic review and meta-analysis of randomized controlled trials
The widespread use of central venous catheters (CVCs) has exposed patients to a high risk of catheter-related infection (CRI), which is linked to substantial morbidity and mortality. Several strategies for preventing CRI, including ethanol lock prophylaxis, have been explored. This study aimed to pr...
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| Published in | PloS one Vol. 14; no. 9; p. e0222408 |
|---|---|
| Main Authors | , , , |
| Format | Journal Article |
| Language | English |
| Published |
United States
Public Library of Science
12.09.2019
Public Library of Science (PLoS) |
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| Online Access | Get full text |
| ISSN | 1932-6203 1932-6203 |
| DOI | 10.1371/journal.pone.0222408 |
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| Abstract | The widespread use of central venous catheters (CVCs) has exposed patients to a high risk of catheter-related infection (CRI), which is linked to substantial morbidity and mortality. Several strategies for preventing CRI, including ethanol lock prophylaxis, have been explored. This study aimed to provide a comprehensive summary of randomized controlled trials (RCTs) assessing the efficacy and safety of ethanol locks for preventing CRI in patients with CVC.
We searched six electronic databases, earlier relevant meta-analyses and the reference lists of the included studies for RCTs that assessed the effects of ethanol locks on CRI in patients with CVC versus a control group. Two authors independently assessed the methodological quality of the included studies using the Cochrane Risk of Bias tool and extracted relevant information according to a predesigned extraction form. Data were analyzed using the Cochrane Collaboration's RevMan 5.3.
Nine studies involving 2451 patients were included. Although limited in power, the results of the meta-analysis indicated a positive effect of ethanol lock prophylaxis on reducing catheter-related bloodstream infection (CRBSI) compared to heparin alone [OR = 0.53, 95% CI 0.34, 0.82, P = 0.004]. The effects on other outcomes, such as exit site infection, catheter dysfunction, catheter removal, thrombosis and mortality, were not statistically significant (P > 0.05). Moreover, although the effect of ethanol on CRBSI was in the expected direction compared to 0.9% NaCl locks, this effect was not statistically significant (P > 0.05).
The present data indicate that ethanol lock prophylaxis is a potential candidate for the prevention of CRBSI in patients with CVC. However, more attention should be paid to the uniform ethanol lock procedure and toxic effects after long-term ethanol lock exposure. |
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| AbstractList | Background The widespread use of central venous catheters (CVCs) has exposed patients to a high risk of catheter-related infection (CRI), which is linked to substantial morbidity and mortality. Several strategies for preventing CRI, including ethanol lock prophylaxis, have been explored. This study aimed to provide a comprehensive summary of randomized controlled trials (RCTs) assessing the efficacy and safety of ethanol locks for preventing CRI in patients with CVC. Methods We searched six electronic databases, earlier relevant meta-analyses and the reference lists of the included studies for RCTs that assessed the effects of ethanol locks on CRI in patients with CVC versus a control group. Two authors independently assessed the methodological quality of the included studies using the Cochrane Risk of Bias tool and extracted relevant information according to a predesigned extraction form. Data were analyzed using the Cochrane Collaboration’s RevMan 5.3. Results Nine studies involving 2451 patients were included. Although limited in power, the results of the meta-analysis indicated a positive effect of ethanol lock prophylaxis on reducing catheter-related bloodstream infection (CRBSI) compared to heparin alone [OR = 0.53, 95% CI 0.34, 0.82, P = 0.004]. The effects on other outcomes, such as exit site infection, catheter dysfunction, catheter removal, thrombosis and mortality, were not statistically significant (P > 0.05). Moreover, although the effect of ethanol on CRBSI was in the expected direction compared to 0.9% NaCl locks, this effect was not statistically significant (P > 0.05). Conclusions The present data indicate that ethanol lock prophylaxis is a potential candidate for the prevention of CRBSI in patients with CVC. However, more attention should be paid to the uniform ethanol lock procedure and toxic effects after long-term ethanol lock exposure. The widespread use of central venous catheters (CVCs) has exposed patients to a high risk of catheter-related infection (CRI), which is linked to substantial morbidity and mortality. Several strategies for preventing CRI, including ethanol lock prophylaxis, have been explored. This study aimed to provide a comprehensive summary of randomized controlled trials (RCTs) assessing the efficacy and safety of ethanol locks for preventing CRI in patients with CVC. We searched six electronic databases, earlier relevant meta-analyses and the reference lists of the included studies for RCTs that assessed the effects of ethanol locks on CRI in patients with CVC versus a control group. Two authors independently assessed the methodological quality of the included studies using the Cochrane Risk of Bias tool and extracted relevant information according to a predesigned extraction form. Data were analyzed using the Cochrane Collaboration's RevMan 5.3. Nine studies involving 2451 patients were included. Although limited in power, the results of the meta-analysis indicated a positive effect of ethanol lock prophylaxis on reducing catheter-related bloodstream infection (CRBSI) compared to heparin alone [OR = 0.53, 95% CI 0.34, 0.82, P = 0.004]. The effects on other outcomes, such as exit site infection, catheter dysfunction, catheter removal, thrombosis and mortality, were not statistically significant (P > 0.05). Moreover, although the effect of ethanol on CRBSI was in the expected direction compared to 0.9% NaCl locks, this effect was not statistically significant (P > 0.05). The present data indicate that ethanol lock prophylaxis is a potential candidate for the prevention of CRBSI in patients with CVC. However, more attention should be paid to the uniform ethanol lock procedure and toxic effects after long-term ethanol lock exposure. The widespread use of central venous catheters (CVCs) has exposed patients to a high risk of catheter-related infection (CRI), which is linked to substantial morbidity and mortality. Several strategies for preventing CRI, including ethanol lock prophylaxis, have been explored. This study aimed to provide a comprehensive summary of randomized controlled trials (RCTs) assessing the efficacy and safety of ethanol locks for preventing CRI in patients with CVC. We searched six electronic databases, earlier relevant meta-analyses and the reference lists of the included studies for RCTs that assessed the effects of ethanol locks on CRI in patients with CVC versus a control group. Two authors independently assessed the methodological quality of the included studies using the Cochrane Risk of Bias tool and extracted relevant information according to a predesigned extraction form. Data were analyzed using the Cochrane Collaboration's RevMan 5.3. Nine studies involving 2451 patients were included. Although limited in power, the results of the meta-analysis indicated a positive effect of ethanol lock prophylaxis on reducing catheter-related bloodstream infection (CRBSI) compared to heparin alone [OR = 0.53, 95% CI 0.34, 0.82, P = 0.004]. The effects on other outcomes, such as exit site infection, catheter dysfunction, catheter removal, thrombosis and mortality, were not statistically significant (P > 0.05). Moreover, although the effect of ethanol on CRBSI was in the expected direction compared to 0.9% NaCl locks, this effect was not statistically significant (P > 0.05). The present data indicate that ethanol lock prophylaxis is a potential candidate for the prevention of CRBSI in patients with CVC. However, more attention should be paid to the uniform ethanol lock procedure and toxic effects after long-term ethanol lock exposure. The widespread use of central venous catheters (CVCs) has exposed patients to a high risk of catheter-related infection (CRI), which is linked to substantial morbidity and mortality. Several strategies for preventing CRI, including ethanol lock prophylaxis, have been explored. This study aimed to provide a comprehensive summary of randomized controlled trials (RCTs) assessing the efficacy and safety of ethanol locks for preventing CRI in patients with CVC.BACKGROUNDThe widespread use of central venous catheters (CVCs) has exposed patients to a high risk of catheter-related infection (CRI), which is linked to substantial morbidity and mortality. Several strategies for preventing CRI, including ethanol lock prophylaxis, have been explored. This study aimed to provide a comprehensive summary of randomized controlled trials (RCTs) assessing the efficacy and safety of ethanol locks for preventing CRI in patients with CVC.We searched six electronic databases, earlier relevant meta-analyses and the reference lists of the included studies for RCTs that assessed the effects of ethanol locks on CRI in patients with CVC versus a control group. Two authors independently assessed the methodological quality of the included studies using the Cochrane Risk of Bias tool and extracted relevant information according to a predesigned extraction form. Data were analyzed using the Cochrane Collaboration's RevMan 5.3.METHODSWe searched six electronic databases, earlier relevant meta-analyses and the reference lists of the included studies for RCTs that assessed the effects of ethanol locks on CRI in patients with CVC versus a control group. Two authors independently assessed the methodological quality of the included studies using the Cochrane Risk of Bias tool and extracted relevant information according to a predesigned extraction form. Data were analyzed using the Cochrane Collaboration's RevMan 5.3.Nine studies involving 2451 patients were included. Although limited in power, the results of the meta-analysis indicated a positive effect of ethanol lock prophylaxis on reducing catheter-related bloodstream infection (CRBSI) compared to heparin alone [OR = 0.53, 95% CI 0.34, 0.82, P = 0.004]. The effects on other outcomes, such as exit site infection, catheter dysfunction, catheter removal, thrombosis and mortality, were not statistically significant (P > 0.05). Moreover, although the effect of ethanol on CRBSI was in the expected direction compared to 0.9% NaCl locks, this effect was not statistically significant (P > 0.05).RESULTSNine studies involving 2451 patients were included. Although limited in power, the results of the meta-analysis indicated a positive effect of ethanol lock prophylaxis on reducing catheter-related bloodstream infection (CRBSI) compared to heparin alone [OR = 0.53, 95% CI 0.34, 0.82, P = 0.004]. The effects on other outcomes, such as exit site infection, catheter dysfunction, catheter removal, thrombosis and mortality, were not statistically significant (P > 0.05). Moreover, although the effect of ethanol on CRBSI was in the expected direction compared to 0.9% NaCl locks, this effect was not statistically significant (P > 0.05).The present data indicate that ethanol lock prophylaxis is a potential candidate for the prevention of CRBSI in patients with CVC. However, more attention should be paid to the uniform ethanol lock procedure and toxic effects after long-term ethanol lock exposure.CONCLUSIONSThe present data indicate that ethanol lock prophylaxis is a potential candidate for the prevention of CRBSI in patients with CVC. However, more attention should be paid to the uniform ethanol lock procedure and toxic effects after long-term ethanol lock exposure. BackgroundThe widespread use of central venous catheters (CVCs) has exposed patients to a high risk of catheter-related infection (CRI), which is linked to substantial morbidity and mortality. Several strategies for preventing CRI, including ethanol lock prophylaxis, have been explored. This study aimed to provide a comprehensive summary of randomized controlled trials (RCTs) assessing the efficacy and safety of ethanol locks for preventing CRI in patients with CVC.MethodsWe searched six electronic databases, earlier relevant meta-analyses and the reference lists of the included studies for RCTs that assessed the effects of ethanol locks on CRI in patients with CVC versus a control group. Two authors independently assessed the methodological quality of the included studies using the Cochrane Risk of Bias tool and extracted relevant information according to a predesigned extraction form. Data were analyzed using the Cochrane Collaboration's RevMan 5.3.ResultsNine studies involving 2451 patients were included. Although limited in power, the results of the meta-analysis indicated a positive effect of ethanol lock prophylaxis on reducing catheter-related bloodstream infection (CRBSI) compared to heparin alone [OR = 0.53, 95% CI 0.34, 0.82, P = 0.004]. The effects on other outcomes, such as exit site infection, catheter dysfunction, catheter removal, thrombosis and mortality, were not statistically significant (P > 0.05). Moreover, although the effect of ethanol on CRBSI was in the expected direction compared to 0.9% NaCl locks, this effect was not statistically significant (P > 0.05).ConclusionsThe present data indicate that ethanol lock prophylaxis is a potential candidate for the prevention of CRBSI in patients with CVC. However, more attention should be paid to the uniform ethanol lock procedure and toxic effects after long-term ethanol lock exposure. Background The widespread use of central venous catheters (CVCs) has exposed patients to a high risk of catheter-related infection (CRI), which is linked to substantial morbidity and mortality. Several strategies for preventing CRI, including ethanol lock prophylaxis, have been explored. This study aimed to provide a comprehensive summary of randomized controlled trials (RCTs) assessing the efficacy and safety of ethanol locks for preventing CRI in patients with CVC. Methods We searched six electronic databases, earlier relevant meta-analyses and the reference lists of the included studies for RCTs that assessed the effects of ethanol locks on CRI in patients with CVC versus a control group. Two authors independently assessed the methodological quality of the included studies using the Cochrane Risk of Bias tool and extracted relevant information according to a predesigned extraction form. Data were analyzed using the Cochrane Collaboration’s RevMan 5.3. Results Nine studies involving 2451 patients were included. Although limited in power, the results of the meta-analysis indicated a positive effect of ethanol lock prophylaxis on reducing catheter-related bloodstream infection (CRBSI) compared to heparin alone [OR = 0.53, 95% CI 0.34, 0.82, P = 0.004]. The effects on other outcomes, such as exit site infection, catheter dysfunction, catheter removal, thrombosis and mortality, were not statistically significant (P > 0.05). Moreover, although the effect of ethanol on CRBSI was in the expected direction compared to 0.9% NaCl locks, this effect was not statistically significant (P > 0.05). Conclusions The present data indicate that ethanol lock prophylaxis is a potential candidate for the prevention of CRBSI in patients with CVC. However, more attention should be paid to the uniform ethanol lock procedure and toxic effects after long-term ethanol lock exposure. |
| Audience | Academic |
| Author | Yang, Qin Wang, Bo Wang, Jinxia Zhang, Jun |
| AuthorAffiliation | 2 Department of Special Surgery, the First Hospital of Lanzhou University, Lanzhou, Gansu, China 1 School of Nursing, Gansu University of Chinese Medicine, Lanzhou, Gansu, China University Magna Graecia of Catanzaro, ITALY |
| AuthorAffiliation_xml | – name: University Magna Graecia of Catanzaro, ITALY – name: 1 School of Nursing, Gansu University of Chinese Medicine, Lanzhou, Gansu, China – name: 2 Department of Special Surgery, the First Hospital of Lanzhou University, Lanzhou, Gansu, China |
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| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/31513652$$D View this record in MEDLINE/PubMed |
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| Cites_doi | 10.1186/1471-2369-13-146 10.1086/502607 10.1136/bmj.d5928 10.1177/1060028014524049 10.1046/j.1523-1755.2000.00439.x 10.1097/01.CCM.0000227648.15804.2D 10.1007/s11255-018-1855-4 10.1177/0884533612468009 10.1371/journal.pone.0010840 10.2307/30141082 10.1086/501999 10.1177/0148607187011005507 10.1016/0261-5614(92)90018-L 10.1093/jac/dkn284 10.1016/j.ejca.2015.06.126 10.1093/jac/dku182 10.1016/j.jhin.2005.12.016 10.1093/cid/ciu671 10.1186/s12871-018-0548-y 10.1016/j.clnu.2017.05.009 10.1164/rccm.201408-1431OC 10.1016/j.jpedsurg.2010.05.014 10.1093/jac/dkn291 10.1136/bmjopen-2015-010264 10.1016/j.jhin.2004.04.007 10.1177/0148607107031004302 10.1016/j.jhin.2014.06.007 10.1093/ndt/gfp187 10.1542/peds.2011-1602 10.1016/j.jhin.2009.12.017 10.5414/CNP65342 |
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| Copyright | COPYRIGHT 2019 Public Library of Science 2019 Zhang et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. 2019 Zhang et al 2019 Zhang et al |
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| PublicationYear | 2019 |
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| References | C Rotstein (pone.0222408.ref001) 1995; 16 KB Laupland (pone.0222408.ref006) 2006; 63 B Souweine (pone.0222408.ref023) 2015; 191 AL Bell (pone.0222408.ref034) 2006; 65 JF Yang (pone.0222408.ref019) 2013; 23 G Taylor (pone.0222408.ref004) 2002; 23 JK Broom (pone.0222408.ref018) 2012; 13 J Sanders (pone.0222408.ref016) 2008; 62 pone.0222408.ref020 JP Higgins (pone.0222408.ref015) 2011; 343 D Balestrino (pone.0222408.ref029) 2009; 24 ML Kayton (pone.0222408.ref011) 2010; 45 DK Warren (pone.0222408.ref005) 2006; 34 L Slobbe (pone.0222408.ref017) 2010; 5 BR Salonen (pone.0222408.ref024) 2018; 37 J Zhang (pone.0222408.ref027) 2016; 6 TA Takla (pone.0222408.ref028) 2008; 62 M Tan (pone.0222408.ref026) 2014; 48 A Crispin (pone.0222408.ref003) 2008; 31 IM Zacharioudakis (pone.0222408.ref007) 2014; 59 LJ Worth (pone.0222408.ref021) 2014; 88 CR Pennington (pone.0222408.ref031) 1987; 11 VM Coyle (pone.0222408.ref002) 2004; 57 KP Pieroni (pone.0222408.ref012) 2013; 28 DA Johnston (pone.0222408.ref032) 1992; 11 CJ Crnich (pone.0222408.ref033) 2005; 26 M Snaterse (pone.0222408.ref008) 2010; 75 MJ Oliver (pone.0222408.ref030) 2000; 58 LA Mermel (pone.0222408.ref035) 2014; 69 C Oliveira (pone.0222408.ref025) 2012; 129 JE Taylor (pone.0222408.ref009) 2015 T Zhao (pone.0222408.ref013) 2018; 50 MT Opilla (pone.0222408.ref010) 2007; 31 P Zhang (pone.0222408.ref014) 2018; 18 RA Schoot (pone.0222408.ref022) 2015; 51 |
| References_xml | – volume: 13 start-page: 146 year: 2012 ident: pone.0222408.ref018 article-title: A randomised controlled trial of heparin versus ethanol lock therapy for the prevention of catheter associated infection in haemodialysis patients—the HEALTHY-CATH trial publication-title: BMC Nephrol doi: 10.1186/1471-2369-13-146 – volume: 26 start-page: 708 year: 2005 ident: pone.0222408.ref033 article-title: The effects of prolonged ethanol exposure on the mechanical properties of polyurethane and silicone catheters used for intravascular access publication-title: Infect Control Hosp Epidemiol doi: 10.1086/502607 – volume: 343 start-page: d5928 year: 2011 ident: pone.0222408.ref015 article-title: The Cochrane Collaboration’s tool for assessing risk of bias in randomised trials publication-title: BMJ doi: 10.1136/bmj.d5928 – volume: 48 start-page: 607 year: 2014 ident: pone.0222408.ref026 article-title: Ethanol locks in the prevention and treatment of catheter-related bloodstream infections publication-title: Ann Pharmacother doi: 10.1177/1060028014524049 – volume: 58 start-page: 2543 year: 2000 ident: pone.0222408.ref030 article-title: Risk of bacteremia from temporary hemodialysis catheters by site of insertion and duration of use: a prospective study publication-title: Kidney Int doi: 10.1046/j.1523-1755.2000.00439.x – volume: 34 start-page: 2084 year: 2006 ident: pone.0222408.ref005 article-title: Attributable cost of catheter-associated bloodstream infections among intensive care patients in a nonteaching hospital publication-title: Crit Care Med doi: 10.1097/01.CCM.0000227648.15804.2D – start-page: CD010336 year: 2015 ident: pone.0222408.ref009 article-title: Antibiotic lock for the prevention of catheter-related infection in neonates publication-title: Cochrane Database Syst Rev – volume: 50 start-page: 1643 year: 2018 ident: pone.0222408.ref013 article-title: Ethanol lock is effective on reducing the incidence of tunneled catheter-related bloodstream infections in hemodialysis patients: a systematic review and meta-analysis publication-title: Int Urol Nephrol doi: 10.1007/s11255-018-1855-4 – volume: 28 start-page: 226 year: 2013 ident: pone.0222408.ref012 article-title: Evaluation of ethanol lock therapy in pediatric patients on long-term parenteral nutrition publication-title: Nutr Clin Pract doi: 10.1177/0884533612468009 – volume: 5 start-page: e10840 year: 2010 ident: pone.0222408.ref017 article-title: Prevention of catheter-related bacteremia with a daily ethanol lock in patients with tunnelled catheters: a randomized, placebo-controlled trial publication-title: PLoS One doi: 10.1371/journal.pone.0010840 – volume: 16 start-page: 451 year: 1995 ident: pone.0222408.ref001 article-title: The incidence of first Hickman catheter-related infection and predictors of catheter removal in cancer patients publication-title: Infect Control Hosp Epidemiol doi: 10.2307/30141082 – volume: 23 start-page: 716 year: 2002 ident: pone.0222408.ref004 article-title: Prospective surveillance for primary bloodstream infections occurring in Canadian hemodialysis units publication-title: Infect Control Hosp Epidemiol doi: 10.1086/501999 – volume: 11 start-page: 507 year: 1987 ident: pone.0222408.ref031 article-title: Ethanol lock in the management of catheter occlusion publication-title: JPEN J Parenter Enteral Nutr doi: 10.1177/0148607187011005507 – volume: 11 start-page: 97 year: 1992 ident: pone.0222408.ref032 article-title: Ethanol flush for the prevention of catheter occlusion publication-title: Clin Nutr doi: 10.1016/0261-5614(92)90018-L – volume: 62 start-page: 809 year: 2008 ident: pone.0222408.ref016 article-title: A prospective double-blind randomized trial comparing intraluminal ethanol with heparinized saline for the prevention of catheter-associated bloodstream infection in immunosuppressed haematology patients publication-title: J Antimicrob Chemother doi: 10.1093/jac/dkn284 – volume: 51 start-page: 2031 year: 2015 ident: pone.0222408.ref022 article-title: Prevention of central venous catheter-associated bloodstream infections in paediatric oncology patients using 70% ethanol locks: A randomised controlled multi-centre trial publication-title: Eur J Cancer doi: 10.1016/j.ejca.2015.06.126 – volume: 69 start-page: 2611 year: 2014 ident: pone.0222408.ref035 article-title: Adverse effects associated with ethanol catheter lock solutions: a systematic review publication-title: J Antimicrob Chemother doi: 10.1093/jac/dku182 – volume: 63 start-page: 124 year: 2006 ident: pone.0222408.ref006 article-title: Cost of intensive care unit-acquired bloodstream infections publication-title: J Hosp Infect doi: 10.1016/j.jhin.2005.12.016 – volume: 59 start-page: 1741 year: 2014 ident: pone.0222408.ref007 article-title: Antimicrobial lock solutions as a method to prevent central line-associated bloodstream infections: a meta-analysis of randomized controlled trials publication-title: Clin Infect Dis doi: 10.1093/cid/ciu671 – volume: 18 start-page: 93 year: 2018 ident: pone.0222408.ref014 article-title: Ethanol locks for the prevention of catheter-related bloodstream infection: a meta-analysis of randomized control trials publication-title: BMC Anesthesiol doi: 10.1186/s12871-018-0548-y – volume: 37 start-page: 1181 year: 2018 ident: pone.0222408.ref024 article-title: A prospective double blind randomized controlled study on the use of ethanol locks in HPN patients publication-title: Clin Nutr doi: 10.1016/j.clnu.2017.05.009 – volume: 191 start-page: 1024 year: 2015 ident: pone.0222408.ref023 article-title: Ethanol lock and risk of hemodialysis catheter infection in critically ill patients. A randomized controlled trial publication-title: Am J Respir Crit Care Med doi: 10.1164/rccm.201408-1431OC – volume: 45 start-page: 1961 year: 2010 ident: pone.0222408.ref011 article-title: Preliminary results of a phase I trial of prophylactic ethanol-lock administration to prevent mediport catheter-related bloodstream infections publication-title: J Pediatr Surg doi: 10.1016/j.jpedsurg.2010.05.014 – volume: 62 start-page: 1024 year: 2008 ident: pone.0222408.ref028 article-title: Effectiveness of a 30% ethanol/4% trisodium citrate locking solution in preventing biofilm formation by organisms causing haemodialysis catheter-related infections publication-title: J Antimicrob Chemother doi: 10.1093/jac/dkn291 – volume: 6 start-page: e010264 year: 2016 ident: pone.0222408.ref027 article-title: Antimicrobial lock solutions for the prevention of catheter-related infection in patients undergoing haemodialysis: study protocol for network meta-analysis of randomised controlled trials publication-title: BMJ Open doi: 10.1136/bmjopen-2015-010264 – volume: 23 start-page: 318 year: 2013 ident: pone.0222408.ref019 article-title: Application of ethanol locks in maintenance hemodialysis patients with long-term catheter indwelling publication-title: Chin J Nosocomiol – volume: 57 start-page: 325 year: 2004 ident: pone.0222408.ref002 article-title: Catheter-related bloodstream infection in adult haematology patients: catheter removal practice and outcome publication-title: J Hosp Infect doi: 10.1016/j.jhin.2004.04.007 – volume: 31 start-page: 302 year: 2007 ident: pone.0222408.ref010 article-title: Use of ethanol lock therapy to reduce the incidence of catheter-related bloodstream infections in home parenteral nutrition patients publication-title: JPEN J Parenter Enteral Nutr doi: 10.1177/0148607107031004302 – volume: 88 start-page: 48 year: 2014 ident: pone.0222408.ref021 article-title: Ethanol versus heparin locks for the prevention of central venous catheter-associated bloodstream infections: a randomized trial in adult haematology patients with Hickman devices publication-title: J Hosp Infect doi: 10.1016/j.jhin.2014.06.007 – volume: 24 start-page: 3204 year: 2009 ident: pone.0222408.ref029 article-title: Eradication of microorganisms embedded in biofilm by an ethanol-based catheter lock solution publication-title: Nephrol Dial Transplant doi: 10.1093/ndt/gfp187 – ident: pone.0222408.ref020 – volume: 129 start-page: 318 year: 2012 ident: pone.0222408.ref025 article-title: Ethanol locks to prevent catheter-related bloodstream infections in parenteral nutrition: a meta-analysis publication-title: Pediatrics doi: 10.1542/peds.2011-1602 – volume: 31 start-page: 605 year: 2008 ident: pone.0222408.ref003 article-title: Central venous catheter complications during home parenteral nutrition: a prospective pilot study of 481 patients with more than 30,000 catheter days publication-title: Onkologie – volume: 75 start-page: 1 year: 2010 ident: pone.0222408.ref008 article-title: Antibiotic-based catheter lock solutions for prevention of catheter-related bloodstream infection: a systematic review of randomised controlled trials publication-title: J Hosp Infect doi: 10.1016/j.jhin.2009.12.017 – volume: 65 start-page: 342 year: 2006 ident: pone.0222408.ref034 article-title: Effect of ethanol/trisodium citrate lock on the mechanical properties of carbothane hemodialysis catheters publication-title: Clin Nephrol doi: 10.5414/CNP65342 |
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| Snippet | The widespread use of central venous catheters (CVCs) has exposed patients to a high risk of catheter-related infection (CRI), which is linked to substantial... Background The widespread use of central venous catheters (CVCs) has exposed patients to a high risk of catheter-related infection (CRI), which is linked to... BackgroundThe widespread use of central venous catheters (CVCs) has exposed patients to a high risk of catheter-related infection (CRI), which is linked to... Background The widespread use of central venous catheters (CVCs) has exposed patients to a high risk of catheter-related infection (CRI), which is linked to... |
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| SubjectTerms | Analysis Anticoagulants Anticoagulants - therapeutic use Biology and Life Sciences Catheter-Related Infections - microbiology Catheter-Related Infections - prevention & control Catheterization Catheterization, Central Venous - adverse effects Catheterization, Central Venous - methods Catheters Central venous catheters Central Venous Catheters - adverse effects Central Venous Catheters - microbiology Child health Clinical trials Complications and side effects Critically ill persons Engineering and Technology Ethanol Ethanol - metabolism Ethanol - therapeutic use Health aspects Health risks Hemodialysis Heparin Heparin - therapeutic use Humans Infection Infections Medical instruments Medical research Medicine and Health Sciences Meta-analysis Morbidity Mortality Physical Sciences Prevention Prophylaxis Quality assessment Randomization Research and Analysis Methods Risk factors Sodium chloride Statistical analysis Statistical significance Systematic review Thromboembolism Thrombosis Thrombosis - etiology Toxicity |
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| Title | Ethanol locks for the prevention of catheter-related infection in patients with central venous catheter: A systematic review and meta-analysis of randomized controlled trials |
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