Suitability of Tartrate-Resistant Acid Phosphatase Type 5b as a Screening Marker for Bone Mineral Density in Community-Dwelling Elderly Individuals

• Published in: The Tohoku Journal of Experimental Medicine Vol. 224; no. 2; pp. 105 - 110
• Main Authors: Irie, Sumiko, Hayashida, Naomi, Shinkawa, Tetsuko, Taira, Yasuyuki, Sekitani, Yui, Teraoka, Seitaro, Hashiguchi, Kanami, Yoshida, Koji, Morishita, Michiko, Takamura, Noboru
• Format: Journal Article
• Language: English
• Published: Japan Tohoku University Medical Press 2011
• Subjects: Acid Phosphatase - blood; Aged; Aged, 80 and over; Biomarkers - blood; Bone Density; bone mineral density; elderly; Female; Homes for the Aged; Humans; Isoenzymes - blood; Male; Mass Screening - methods; osteoporosis; Osteoporosis - blood; Osteoporosis - diagnosis; screening; Tartrate-Resistant Acid Phosphatase; tartrate-resistant acid phosphatase type 5b

Osteoporosis is a common disorder in aging populations that imposes considerable health problems. Tartrate-resistant acid phosphatase type 5b (TRAP-5b) is derived from osteoclasts, and is involved in normal bone homeostasis. Recently, a novel assay system for TRAP-5b, the fragments absorbed immunoca...