Suitability of Tartrate-Resistant Acid Phosphatase Type 5b as a Screening Marker for Bone Mineral Density in Community-Dwelling Elderly Individuals

Osteoporosis is a common disorder in aging populations that imposes considerable health problems. Tartrate-resistant acid phosphatase type 5b (TRAP-5b) is derived from osteoclasts, and is involved in normal bone homeostasis. Recently, a novel assay system for TRAP-5b, the fragments absorbed immunoca...

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Published inThe Tohoku Journal of Experimental Medicine Vol. 224; no. 2; pp. 105 - 110
Main Authors Irie, Sumiko, Hayashida, Naomi, Shinkawa, Tetsuko, Taira, Yasuyuki, Sekitani, Yui, Teraoka, Seitaro, Hashiguchi, Kanami, Yoshida, Koji, Morishita, Michiko, Takamura, Noboru
Format Journal Article
LanguageEnglish
Published Japan Tohoku University Medical Press 2011
Subjects
Acid Phosphatase - blood
Aged
Aged, 80 and over
Biomarkers - blood
Bone Density
bone mineral density
elderly
Female
Homes for the Aged
Humans
Isoenzymes - blood
Male
Mass Screening - methods
osteoporosis
Osteoporosis - blood
Osteoporosis - diagnosis
screening
Tartrate-Resistant Acid Phosphatase
tartrate-resistant acid phosphatase type 5b
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Abstract Osteoporosis is a common disorder in aging populations that imposes considerable health problems. Tartrate-resistant acid phosphatase type 5b (TRAP-5b) is derived from osteoclasts, and is involved in normal bone homeostasis. Recently, a novel assay system for TRAP-5b, the fragments absorbed immunocapture enzymatic assay method, has been developed. To evaluate the suitability of TRAP-5b as a screening marker for bone mineral density (BMD), we explored the correlations between serum TRAP-5b concentrations and laboratory findings, body mass index, or BMD in 462 community-dwelling elderly individuals (249 men and 213 women, age 73.4 ± 6.5 years) who participated in a regular medical screening program. By multivariate linear regression analysis adjusted for confounding factors, TRAP-5b was significantly correlated with body mass index (β = −0.005, p = 0.043), alkaline phosphatase, a marker for osteoid formation and calcification (β = 0.001, p < 0.001), and triglyceride (β = −0.097, p = 0.016) in men, and with body mass index (β = −0.009, p = 0.025), alkaline phosphatase (β = 0.001, p < 0.001), calcium (β = −0.059, p = 0.039), and bone trabecular area ratio (β = −0.47, p = 0.025) in women. In conclusion, the elevated serum level of TRAP-5b is independently correlated with the decreased BMD in women, but not in men. Because measurement of TRAP-5b is not affected by food intake, and blood samples can be collected at any time of the day, we suggest the suitability of serum TRAP-5b as a simple marker for the evaluation of BMD in women.
AbstractList Osteoporosis is a common disorder in aging populations that imposes considerable health problems. Tartrate-resistant acid phosphatase type 5b (TRAP-5b) is derived from osteoclasts, and is involved in normal bone homeostasis. Recently, a novel assay system for TRAP-5b, the fragments absorbed immunocapture enzymatic assay method, has been developed. To evaluate the suitability of TRAP-5b as a screening marker for bone mineral density (BMD), we explored the correlations between serum TRAP-5b concentrations and laboratory findings, body mass index, or BMD in 462 community-dwelling elderly individuals (249 men and 213 women, age 73.4±6.5 years) who participated in a regular medical screening program. By multivariate linear regression analysis adjusted for confounding factors, TRAP-5b was significantly correlated with body mass index (β=-0.005, p=0.043), alkaline phosphatase, a marker for osteoid formation and calcification (β=0.001, p<0.001), and triglyceride (β=-0.097, p=0.016) in men, and with body mass index (β=-0.009, p=0.025), alkaline phosphatase (β=0.001, p<0.001), calcium (β=-0.059, p=0.039), and bone trabecular area ratio (β=-0.47, p=0.025) in women. In conclusion, the elevated serum level of TRAP-5b is independently correlated with the decreased BMD in women, but not in men. Because measurement of TRAP-5b is not affected by food intake, and blood samples can be collected at any time of the day, we suggest the suitability of serum TRAP-5b as a simple marker for the evaluation of BMD in women.Osteoporosis is a common disorder in aging populations that imposes considerable health problems. Tartrate-resistant acid phosphatase type 5b (TRAP-5b) is derived from osteoclasts, and is involved in normal bone homeostasis. Recently, a novel assay system for TRAP-5b, the fragments absorbed immunocapture enzymatic assay method, has been developed. To evaluate the suitability of TRAP-5b as a screening marker for bone mineral density (BMD), we explored the correlations between serum TRAP-5b concentrations and laboratory findings, body mass index, or BMD in 462 community-dwelling elderly individuals (249 men and 213 women, age 73.4±6.5 years) who participated in a regular medical screening program. By multivariate linear regression analysis adjusted for confounding factors, TRAP-5b was significantly correlated with body mass index (β=-0.005, p=0.043), alkaline phosphatase, a marker for osteoid formation and calcification (β=0.001, p<0.001), and triglyceride (β=-0.097, p=0.016) in men, and with body mass index (β=-0.009, p=0.025), alkaline phosphatase (β=0.001, p<0.001), calcium (β=-0.059, p=0.039), and bone trabecular area ratio (β=-0.47, p=0.025) in women. In conclusion, the elevated serum level of TRAP-5b is independently correlated with the decreased BMD in women, but not in men. Because measurement of TRAP-5b is not affected by food intake, and blood samples can be collected at any time of the day, we suggest the suitability of serum TRAP-5b as a simple marker for the evaluation of BMD in women.
Osteoporosis is a common disorder in aging populations that imposes considerable health problems. Tartrate-resistant acid phosphatase type 5b (TRAP-5b) is derived from osteoclasts, and is involved in normal bone homeostasis. Recently, a novel assay system for TRAP-5b, the fragments absorbed immunocapture enzymatic assay method, has been developed. To evaluate the suitability of TRAP-5b as a screening marker for bone mineral density (BMD), we explored the correlations between serum TRAP-5b concentrations and laboratory findings, body mass index, or BMD in 462 community-dwelling elderly individuals (249 men and 213 women, age 73.4 ± 6.5 years) who participated in a regular medical screening program. By multivariate linear regression analysis adjusted for confounding factors, TRAP-5b was significantly correlated with body mass index (β = −0.005, p = 0.043), alkaline phosphatase, a marker for osteoid formation and calcification (β = 0.001, p < 0.001), and triglyceride (β = −0.097, p = 0.016) in men, and with body mass index (β = −0.009, p = 0.025), alkaline phosphatase (β = 0.001, p < 0.001), calcium (β = −0.059, p = 0.039), and bone trabecular area ratio (β = −0.47, p = 0.025) in women. In conclusion, the elevated serum level of TRAP-5b is independently correlated with the decreased BMD in women, but not in men. Because measurement of TRAP-5b is not affected by food intake, and blood samples can be collected at any time of the day, we suggest the suitability of serum TRAP-5b as a simple marker for the evaluation of BMD in women.
Osteoporosis is a common disorder in aging populations that imposes considerable health problems. Tartrate-resistant acid phosphatase type 5b (TRAP-5b) is derived from osteoclasts, and is involved in normal bone homeostasis. Recently, a novel assay system for TRAP-5b, the fragments absorbed immunocapture enzymatic assay method, has been developed. To evaluate the suitability of TRAP-5b as a screening marker for bone mineral density (BMD), we explored the correlations between serum TRAP-5b concentrations and laboratory findings, body mass index, or BMD in 462 community-dwelling elderly individuals (249 men and 213 women, age 73.4±6.5 years) who participated in a regular medical screening program. By multivariate linear regression analysis adjusted for confounding factors, TRAP-5b was significantly correlated with body mass index (β=-0.005, p=0.043), alkaline phosphatase, a marker for osteoid formation and calcification (β=0.001, p<0.001), and triglyceride (β=-0.097, p=0.016) in men, and with body mass index (β=-0.009, p=0.025), alkaline phosphatase (β=0.001, p<0.001), calcium (β=-0.059, p=0.039), and bone trabecular area ratio (β=-0.47, p=0.025) in women. In conclusion, the elevated serum level of TRAP-5b is independently correlated with the decreased BMD in women, but not in men. Because measurement of TRAP-5b is not affected by food intake, and blood samples can be collected at any time of the day, we suggest the suitability of serum TRAP-5b as a simple marker for the evaluation of BMD in women.
Author Taira, Yasuyuki
Morishita, Michiko
Sekitani, Yui
Teraoka, Seitaro
Shinkawa, Tetsuko
Yoshida, Koji
Hayashida, Naomi
Irie, Sumiko
Hashiguchi, Kanami
Takamura, Noboru
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References_xml – reference: Gerdhem, P., Ivaska, K.K., Alatalo, S.L., Hallen, J.M., Hellman, J., Isaksson, A., Pettersson, K., Väänänen, H.K., Åkesson, K. & Obrant, K.J. (2004) Biochemical markers of bone metabolism and prediction of fracture in elderly women. J. Bone Miner. Res., 19, 386-393.
– reference: Hien, V.T.T., Khan, N.C., Mai, Le.B., Lam, N.T., Phuong, T.M., Nhung, B.T., Nhien, N.V., Nakamori, M. & Yamamoto, S. (2008) Effect of community-based nutrition education intervention on calcium intake and bone mass in postmenopausal Vietnamese women. Public Health Nutr., 12, 674-679.
– reference: Basurto, L., Galván, R., Cordova, N., Saucedo, R., Vargas, C., Campos, S., Halley, E., Avelar, F. & Zárate, A. (2009) Adiponectin is associated with low bone mineral density in elderly men. Eur. J. Endocrinol., 160, 289-293.
– reference: Murano, T., Izumi, S.I., Kika, G., Haque, S.F., Okuwaki, S., Mori, A., Suzuki, T., Matsubayashi, H., Ikeda, M., Goya, K. & Makino, T. (2003) Impact of menopause on lipid and bone metabolism and effect of hormone replacement therapy. Tokai J. Exp. Clin. Med., 28, 109-119.
– reference: Qin, Y.J., Zhang, Z.L., Zhang, H., Hu, W.W., Liu, Y.J., Hu, Y.Q., Li, M., Gu, J.M. & He, J.W. (2008) Age-related changes of serum tartrate-resistant acid phosphatase 5b and the relationship with bone mineral density in Chinese women. Acta. Pharmacol. Sin., 29, 1493-1498.
– reference: Halleen, J.M., Alatalo, S.L., Suominen, H., Cheng, S., Janckila, A.J. & Väänänen, H.K. (2000) Tartrate-resistant acid phosphatase 5b: a novel serum marker of bone resorption. J. Bone Miner. Res., 15, 1337-1345.
– reference: Yamauchi, H., Fukunaga, M., Nishikawa, A. & Orimo, H. (2010) Changes in distribution of bone densitometry equipment from 1996 to 2006 in Japan. J. Bone Miner. Metab., 28, 60-67.
– reference: Izumotani, K., Hagiwara, S., Izumotani, T., Miki, T., Morii, H. & Nishizawa, Y. (2003) Risk factors for osteoporosis in men. J. Bone Miner. Metab., 21, 86-90.
– reference: Fujiwara, S., Sone, T., Yamazaki, K., Yoshimura, N., Nakatsuka, K., Masunari, N., Fujita, S., Kushida, K. & Fukunaga, M. (2005) Heel bone ultrasound predicts non-spine fracture in Japanese men and women. Osteoporos. Int., 16, 2107-2112.
– reference: Lenora, J., Ivaska, K.K., Obrant, K.J. & Gerdhem, P. (2007) Prediction of bone loss using biochemical markers of bone turnover. Osteoporos. Int., 18, 1297-1305.
– reference: Hannan, M.T., Felson, D.T., Dawson-Hughes, B., Tucker, K.L., Cupples, L.A., Wilson, P.W. & Kiel, D.P. (2000) Risk factors for longitudinal bone loss in elderly men and women: The Framingham Osteoporosis Study. J. Bone Miner. Res., 15, 710-720.
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Snippet Osteoporosis is a common disorder in aging populations that imposes considerable health problems. Tartrate-resistant acid phosphatase type 5b (TRAP-5b) is...
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SubjectTerms Acid Phosphatase - blood
Aged
Aged, 80 and over
Biomarkers - blood
Bone Density
bone mineral density
elderly
Female
Homes for the Aged
Humans
Isoenzymes - blood
Male
Mass Screening - methods
osteoporosis
Osteoporosis - blood
Osteoporosis - diagnosis
screening
Tartrate-Resistant Acid Phosphatase
tartrate-resistant acid phosphatase type 5b
Title Suitability of Tartrate-Resistant Acid Phosphatase Type 5b as a Screening Marker for Bone Mineral Density in Community-Dwelling Elderly Individuals
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https://www.ncbi.nlm.nih.gov/pubmed/21597244
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Volume 224
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ispartofPNX The Tohoku Journal of Experimental Medicine, 2011, Vol.224(2), pp.105-110
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