Transient receptor potential cation channel, subfamily C, member 5 (TRPC5) is a cold-transducer in the peripheral nervous system

• Published in: Proceedings of the National Academy of Sciences - PNAS Vol. 108; no. 44; pp. 18114 - 18119
• Main Authors: Zimmermann, Katharina, Lennerz, Jochen K, Hein, Alexander, Link, Andrea S, Kaczmarek, J. Stefan, Delling, Markus, Uysal, Serdar, Pfeifer, John D, Riccio, Antonio, Clapham, David E
• Format: Journal Article
• Language: English
• Published: United States National Academy of Sciences 01.11.2011; National Acad Sciences
• Subjects: Action potentials; Adaptations; Animals; Biological Sciences; Body Temperature Regulation - physiology; cation channels; Cold; Cold Temperature; Cooling; Dorsal root ganglia; ganglia; Ganglia, Spinal - cytology; Ganglia, Spinal - metabolism; Human subjects; Humans; Immunohistochemistry; Ion channels; Menthol; Mice; Mice, Knockout; Nerve endings; Nerves; Neurochemistry; Neurons; Neurons - metabolism; Nociceptors; Pain; Pain perception; Patch-Clamp Techniques; Peripheral nerves; Peripheral nervous system; Peripheral Nervous System - metabolism; Peripheral Nervous System - physiology; Receptors; Rodents; Sensory neurons; Sensory perception; Skin; Spinal cord; Spinal Cord - metabolism; Survival; temperature; Temperature effects; transient receptor potential proteins; Vesicular Transport Proteins - genetics; Vesicular Transport Proteins - physiology

Detection and adaptation to cold temperature is crucial to survival. Cold sensing in the innocuous range of cold (>10–15 °C) in the mammalian peripheral nervous system is thought to rely primarily on transient receptor potential (TRP) ion channels, most notably the menthol receptor, TRPM8. Here w...